Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
First Claim
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1. An isolated CD45−
- umbilicus-derived cell having a cell surface marker profile wherein the cell produces one or more of CD10, CD13, CD44, CD73, CD90, PDGFr-alpha, or HLA-A, B, C, and does not express one or more of CD31, CD34, CD117, CD141, or HLA-DR, DP, DQ, as detected by flow cytometry.
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Abstract
Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
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Citations
9 Claims
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1. An isolated CD45−
- umbilicus-derived cell having a cell surface marker profile wherein the cell produces one or more of CD10, CD13, CD44, CD73, CD90, PDGFr-alpha, or HLA-A, B, C, and does not express one or more of CD31, CD34, CD117, CD141, or HLA-DR, DP, DQ, as detected by flow cytometry.
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Specification