Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye

• US 20070036829A1
• Filed: 05/03/2006
• Published: 02/15/2007
• Est. Priority Date: 03/18/2003
• Status: Abandoned Application

• Current Assignee: Advanced Medical Optics Incorporated (Johnson & Johnson)
• Original Assignee: Advanced Medical Optics Incorporated (Johnson & Johnson)
• Inventors: Yu, Zhi-Jian, Huth, Stanley
• Application Number:
  US11/417,891
• Publication Number:
  US 20070036829A1
• Time in Patent Office: Days
• US Class Current: 424/400
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/728 Hyaluronic acid
• CPC Class Codes: A61K 36/535 Perilla (beefsteak plant)
• CPC Class Codes: A61K 36/55 Linaceae (Flax family), e.g. Linum
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/08 containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
• CPC Class Codes: A61K 47/44 Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/10 Dispersions; Emulsions A61K9/06 takes precedence; composition of dispersions, emulsions A61K47/00
• CPC Class Codes: A61K 9/107 Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61L 12/141 Biguanides, e.g. chlorhexidine
• CPC Class Codes: A61L 12/142 Polymeric biguanides
• CPC Class Codes: A61L 12/143 Quaternary ammonium compounds
• CPC Class Codes: A61P 27/04 Artificial tears; Irrigation solutions

Abstract

An ophthalmic composition is self-emulsifying. The composition includes oil globules having an average size of less than 1 micron dispersed in an aqueous phase. These globules include a surfactant component with one or two surfactants and a polar oil component. The surfactant component and the oil component are selected to self-emulsify when mixed without mechanical homogenization. The composition also includes a disinfectant suitable for ophthalmic use, and can optionally include a therapeutic agent suitable for ophthalmic treatment.

Claims

1. An ophthalmic composition that is self-emulsifying comprising:

(a) oil globules having an average size of less than 1 micron dispersed in an aqueous phase;

said globules comprising;

(i) a surfactant component consisting essentially of one or two surfactants; and

(ii) a polar oil component, said surfactant component and said oil component selected to self-emulsify when mixed without mechanical homogenization; and

(b) a disinfectant suitable for ophthalmic use.

2. The ophthalmic composition of claim 1, additionally comprising a therapeutic agent suitable for ophthalmic treatment.