Porous materials having multi-size geometries

• US 20070036844A1
• Filed: 07/31/2006
• Published: 02/15/2007
• Est. Priority Date: 08/01/2005
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Ma, Peter, Chen, Victor
• Application Number:
  US11/496,238
• Publication Number:
  US 20070036844A1
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: B29C 67/20 for porous or cellular articles, e.g. of foam plastics, coarse-pored chemical aspects of working up macro-molecular substances to porous or cellular articles C08J9/00

Abstract

A method for forming a porous three-dimensional (3-D) object includes creating a mold from a negative replica of the 3-D object, the 3-D object having a first size and at least one predetermined feature, and then casting a flowable material into and/or onto the mold. The method further includes forming pores of a second size and/or a third size in the flowable material, thereby forming the porous 3-D object.

Claims

1. A method for forming a porous three-dimensional (3-D) object, comprising:

creating a mold from a negative replica of the 3-D object, the 3-D object having a first size and at least one predetermined feature;

casting a flowable material at least one of into or onto the mold; and

forming pores of at least one of a second size or a third size in the flowable material, thereby forming the porous 3-D object.

2. The method as defined in claim 1, further comprising removing the mold from the porous 3-D object.

3. The method as defined in claim 2 wherein removing the mold is accomplished by at least one of dissolution, melting, sublimation, evaporation, burning, or combinations thereof.

4. The method as defined in claim 1, wherein before creating the mold, the method further comprises at least one of designing or obtaining a 3-D image of the 3-D object.

5. The method as defined in claim 1 wherein at least one of the first size, the second size or the third size is different from at least an other of the first size, the second size or the third size.

6. The method as defined in claim 1 wherein the first size is greater than the second size, and the second size is greater than the third size.

7. The method as defined in claim 1 wherein the 3-D object has at least one of predetermined mechanical properties, predetermined physical properties, predetermined physiological properties, predetermined biological properties, predetermined chemical properties, or combinations thereof.

8. The method as defined in claim 1 wherein forming the pores further includes forming pre-designed interconnected open pores.

9. The method as defined in claim 1 wherein forming the pores is accomplished by at least one of phase separation, evaporation, sublimation, etching, gas generation, particulate-leaching, or combinations thereof.

10. The method as defined in claim 1, further comprising:

introducing a porogen material to the mold prior to casting the flowable material; and

removing the porogen material from the 3-D object.

11. The method as defined in claim 1 wherein the pores are formed in the flowable material prior to casting the flowable material.

12. The method as defined in claim 1 wherein the pores are formed in the flowable material after casting the flowable material.

13. The method as defined in claim 1 wherein the flowable material is selected from synthetic polymers, natural macromolecules, natural polymers, organic compounds, inorganic compounds, metals, and combinations thereof.

14. A porous 3-D object formed by the process as defined in claim 1.

15. A porous three-dimensional (3-D) object, comprising:

a solidified flowable material having a first size and at least one predetermined feature defined by a mold having a negative replica of the three-dimensional object; and

a plurality of pores defined throughout the solidified flowable material, at least some of the plurality of pores having a second size, and at least some other of the plurality of pores having a third size.

16. The porous 3-D object as defined in claim 15 wherein the first size is greater than or equal to about 10⁻

3, wherein the second size ranges from about 10<sup>−

6</sup> m to about 10<sup>−

3</sup> m, and wherein the third size ranges from about 10<sup>−

9</sup> m to about 10<sup>−

6</sup> m.

17. The porous 3-D object as defined in claim 15 wherein the 3-D object has at least one of predetermined mechanical properties, predetermined physical properties, predetermined physiological properties, predetermined biological properties, predetermined chemical properties, or combinations thereof.

18. The porous 3-D object as defined in claim 15, further comprising at least one of the plurality of pores having a shape selected from a computer designed shape, a porogen-defined shape, a predesigned interconnected open pore shape, and combinations thereof.

19. The porous 3-D object as defined in claim 15 wherein the flowable material is selected from synthetic polymers, natural macromolecules, natural polymers, organic compounds, inorganic compounds, metals, and combinations thereof.

20. The porous 3-D object as defined in claim 15 wherein the porous 3-D object is a three-dimensional polymer scaffold with micrometer and nanometer-scaled fibers.

21. A method of forming a 3-D object, comprising:

designing or obtaining a 3-D image of the 3-D object, the 3-D object having a first size and at least one predetermined feature;

creating a mold from a negative replica of the 3-D image;

casting a flowable material at least one of into or onto the mold;

forming pores of at least one of a second size or a third size in the flowable material, thereby forming the porous 3-D object; and

removing the mold from the porous 3-D object.

22. The method as defined in claim 21 wherein removing the mold is accomplished by at least one of dissolution, melting, sublimation, evaporation, burning, or combinations thereof.

23. The method as defined in claim 21 wherein at least one of the first size, the second size or the third size is different from at least an other of the first size, the second size or the third size.

24. The method as defined in claim 23 wherein the first size is greater than the second size, and the second size is greater than the third size.

25. The method as defined in claim 21 wherein forming the pores further includes forming pre-designed interconnected open pores.

26. The method as defined in claim 21 wherein forming the pores is accomplished by at least one of phase separation, evaporation, sublimation, etching, gas generation, particulate-leaching, or combinations thereof.

27. The method as defined in claim 21, further comprising:

introducing a porogen material to the mold prior to casting the flowable material; and

removing the porogen material from the 3-D object.

28. The method as defined in claim 21 wherein the pores are formed in the flowable material prior to casting the flowable material or after casting the flowable material.

29. The method as defined in claim 21 wherein the flowable material is selected from synthetic polymers, natural macromolecules, natural polymers, organic compounds, inorganic compounds, metals, and combinations thereof.

30. A porous 3-D object formed by the process as defined in claim 21.