Wound dressing and method of manufacture thereof

• US 20070036846A1
• Filed: 08/15/2005
• Published: 02/15/2007
• Est. Priority Date: 08/15/2005
• Status: Abandoned Application

• Current Assignee: Maxford Medical Technology Co., Ltd.
• Original Assignee: Maxford Medical Technology Co., Ltd.
• Inventors: Tsang, Wing
• Application Number:
  US11/204,499
• Publication Number:
  US 20070036846A1
• Time in Patent Office: Days
• US Class Current: 424/445
• CPC Class Codes: A61K 31/205 Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 26/0014 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 26/0019 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 26/0023 Polysaccharides
• CPC Class Codes: A61L 26/0066 Medicaments; Biocides
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 5/12 Agar or agar-agar , i.e. mixture of agarose and agaropectin; Derivatives thereof
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

A hydrogel dressing for covering or treating a wound, a surgical incision, a catheter insertion site or the like, comprising a non-fluid sheet material including a structure of cross-linked polymers and/or monomers having suspended therein an agent for controlling infection of the wound, the incision, the catheter insertion site or the like.

Claims

1. A hydrogel dressing for covering or treating a wound, a surgical incision, a catheter insertion site or the like, comprising a non-fluid sheet material including a structure of cross-linked polymers and/or monomers having suspended therein an agent for controlling infection of the wound, the incision, the catheter insertion site or the like.

2. A dressing as claimed in claim 1 comprising at least 80 wt % of purified water.

3. A dressing as claimed in claim 1 wherein said infection control agent is an anti-bacterial agent.

4. A dressing as claimed in claim 1 wherein said infection control agent is an anti-microbial agent.

5. A dressing as claimed in claim 1 wherein said infection control agent comprises a chlorhexidine composition selected from the group including hibitane, chlorhexidine acetate, chlorhexidine gluconate and chlorhexidine hydrochloride.

6. A dressing as claimed in claim 1 comprising 0.025 to 0.75 wt % of said infection control agent.

7. A dressing as claimed in claim 1 wherein said cross-linked structure comprises a synthetic polymer such as polyacrylamide, polyvinylpyrolidone, their monomers or their mixtures, and/or a natural polymer such as gelatine or agar, or mixtures thereof.

8. A dressing as claimed in claim 1 further comprising a plasticizing agent.

9. A dressing as claimed in claim 8 wherein said plasticizing agent is selected from the group including ethylene glycol, polyethylene glycol, propylene glycol and polypropylene glycol.

10. A dressing as claimed in claim 1 wherein said sheet material is a moisture balancer for the wound, the surgical incision, the catheter insertion site or the like treated.

11. A dressing as claimed in claim 1 wherein said sheet material acts as a disinfectant or an antiseptic agent.

12. A dressing as claimed in claim 1 wherein said cross-linked structure comprises means for absorbing discharges such as pus or exudates from the wound, the surgical incision, the catheter insertion site or the like.

13. A method of dressing a wound, a surgical incision, a catheter insertion site or the like, comprising applying thereon a dressing as claimed in claim 1.

14. A method of manufacture of a dressing for a wound, a surgical incision, a catheter insertion site or the like, comprising the steps of:

(a) preparing a mixture of ingredients including at least 80 wt % of purified water, 0.025 to 0.75 wt % of an agent for controlling infection or inhibiting growth of bacteria or microbes, and monomers and/or polymers to be cross-linked together;

(b) placing said mixture in a mould having a desired shape; and

(c) solidifying said mixture by subjecting said mixture in said mould to an ionizing radiation in the magnitude of at least 20 kGy or an electron beam and cross-linking said monomers and said polymers in said mixture to form a crosslinked polymer sheet structure.

15. A method as claimed in claim 14 wherein said agent comprises a chlorhexidine composition selected from the group including hibitane, chlorhexdine acetate, chlorhexdine gluconate and chlorhexidine hydrochloride.

16. A method as claimed in claim 14 wherein said monomers or said polymers are natural polymers, synthetic monomers or synthetic polymers.

17. A method as claimed in claim 16 wherein said mixture comprises 5 wt % to 12 wt % of said synthetic monomers or polymers.

18. A method as claimed in claim 16 wherein said mixture comprises no more than 4 wt % of said natural polymers.

19. A method as claimed in claim 14 wherein said polymers are selected from the group including polyacrylamide, polyvinylpyrolidone, gelatine and agar.

20. A method as claimed in claim 14 wherein said ionizing radiation is gamma radiation.

21. A method of manufacture of a dressing for a wound, a surgical incision, a catheter insertion site or the like, comprising the steps of:

(a) preparing a mixture of ingredients including at least 80 wt % of purified water, 0.025 to 0.75 wt % of a chlorhexidine composition for controlling infection or inhibiting growth of bacteria or microbes, and monomers and/or polymers to be cross-linked together;

(b) placing said mixture in a mould having a desired shape; and

(c) solidifying said mixture by subjecting said mixture in said mould to an ionizing radiation.

22. A method as claimed in claim 21 wherein said ionizing radiation is in the magnitude of at least 20 kGy.

23. A method as claimed in claim 21 wherein said ionizing radiation is gamma radiation or an electron beam.