Pharmacokinetic-based culture system with biological barriers
First Claim
1. A device comprising:
- at least one microscale feature dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to the value of at least one pharmacokinetic parameter found in vivo; and
a permeable material.
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Abstract
Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member. In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes bound to a permeable substrate via a binder.
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Citations
67 Claims
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1. A device comprising:
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at least one microscale feature dimensioned to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to the value of at least one pharmacokinetic parameter found in vivo; and
a permeable material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method comprising:
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maintaining biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to the value of at least one pharmacokinetic parameter found in vivo; and
passing a substance through at least a portion of a permeable material. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. A method of forming a device comprising:
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forming a feature that is configured to maintain biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to the value of at least one pharmacokinetic parameter found in vivo; and
adding, forming, or providing for a permeable material, wherein the permeable material is configured such that a substance passes through at least a portion of the permeable material.
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67. A device comprising:
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means for maintaining biological material under conditions that provide a value of at least one pharmacokinetic parameter in vitro that is comparable to the value of at least one pharmacokinetic parameter found in vivo; and
means for providing a permeable barrier.
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Specification