Airway remodeling treatments

• US 20070037873A1
• Filed: 08/08/2006
• Published: 02/15/2007
• Est. Priority Date: 08/08/2005
• Status: Abandoned Application

• Current Assignee: University Of Massachusetts
• Original Assignee: University Of Massachusetts
• Inventors: Madison, J., Zurier, Robert
• Application Number:
  US11/500,580
• Publication Number:
  US 20070037873A1
• Time in Patent Office: Days
• US Class Current: 514/454
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin

Abstract

Described are new uses for ajulemic acid and derivatives of ajulemic acid to treat airway remodeling.

Claims

1. A method of treating airway remodeling in a subject, the method comprising

identifying a subject in need of treatment for airway remodeling;

and

administering to the subject a pharmaceutical composition comprising an effective dose of ajulemic acid or a derivative thereof.

2. The method of claim 1, wherein the subject has symptoms of asthma;

and the subject displays symptoms of airway obstruction when the subject is not suffering an asthma attack.

3. The method of claim 1, wherein the subject has a history of chronic asthma;

and the subject displays symptoms of airway obstruction when the subject is not suffering an asthma attack.

4. The method of claim 1, wherein the subject (i) has been diagnosed with asthma, (ii) displays symptoms of airway obstruction when the subject is not suffering an asthma attack, and (iii) is being treated with one or more treatments selected from the group consisting of an anti-inflammatory, a steroidal anti-inflammatory, and a bronchodilator.

6. The method of claim 1, wherein the subject has emphysema.

7. The method of claim 1, wherein the subject is suffering from chronic obstructive pulmonary disease.

8. The method of claim 1, wherein the pharmaceutical composition comprises ajulemic acid.

9. The method of claim 1, wherein the subject is suffering from asthma and is being treated with one or more treatments selected from the group consisting of an anti-inflammatory, a steroidal anti-inflammatory, and a bronchodilator.

11. The method of claim 9, wherein the subject is suffering from chronic asthma.

13. The method of claim 9, wherein the pharmaceutical composition comprises ajulemic acid.

14. The method of claim 1, wherein the pharmaceutical composition comprises a dose of ajulemic acid of 1 microgram to about 500 milligrams per kilogram of the subject.

15. The method of claim 1, wherein the pharmaceutical composition is delivered orally.

16. The method of claim 1, wherein the pharmaceutical composition is delivered by inhalation.

17. The method of claim 1, wherein the pharmaceutical composition is administered one or more times a day.

20. The method of claim 1, wherein the pharmaceutical composition is administered with another treatment for asthma.

31. The method of claim 14, wherein the dose is about 100 micrograms to about 200 milligrams per kilogram of the subject.

32. The method of claim 14, wherein the dose is about 100 micrograms to about 5 milligrams per kilogram of the subject.

33. The method of claim 14, wherein the dose is about 200 micrograms to about 2 milligrams per kilogram of the subject.

34. The method of claim 1, wherein the pharmaceutical composition is administered one or more times a week.

5. (canceled)

10. (canceled)

12. (canceled)

18-19. -19. (canceled)

21. A pharmaceutical composition comprising ajulemic acid, or a derivative thereof, and one or more of a solvent, dispersion medium, and propellant suitable for administration by inhalation.

22. A dispenser comprising the pharmaceutical composition of claim 21, wherein the dispenser delivers a dose for inhalation of ajulemic acid of 1 microgram to about 500 milligrams per kilogram of a subject in need of asthma treatment.

23. A pharmaceutical composition comprising ajulemic acid, or a derivative thereof, a second therapeutic agent used to treat asthma, and a pharmaceutically acceptable carrier.

24-30. -30. (canceled)