Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle

• US 20070038119A1
• Filed: 04/17/2006
• Published: 02/15/2007
• Est. Priority Date: 04/18/2005
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Chen, Zhongping, Brenner, Matthew, Xie, Tuqiang, Mukai, David
• Granted Patent: US 7,576,865 B2
• Time in Patent Office: Days
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence

Abstract

A fiber-optic bundle based optical coherence tomography (OCT) probe method is demonstrated in a multimode optical fiber bundle based OCT system. The system can achieve a lateral resolution of 12 μm and an axial resolution of 10 μm using a super-luminescent diode source. This imaging approach eliminates any moving parts in the probe and has a primary advantage for use in extremely compact and safe OCT endoscopes to image internal organs and great potential to be combined with confocal endoscopic microscopy.

Claims

1. An improvement in an OCT system for imaging a sample having a sample arm with a scanner, the improvement comprising a fiber optic bundle having a proximal entrance aperture which is optically coupled to the sample arm through the scanner and having a distal exit aperture optically directed to the sample remote from the scanner.

2. The improvement of claim 1 where the fiber optic bundle is comprised of a plurality of separate single mode or multimode fiber cores.

3. The improvement of claim 1 further comprising scanning optics for focusing a scanning light beam onto the proximal entrance aperture of the fiber optic bundle.

4. The improvement of claim 1 further comprising objective optics for focusing light onto the sample from the distal exit aperture of the fiber optic bundle.

5. The improvement of claim 1 further comprising an endoscopic instrument in which the fiber optic bundle is included.

6. The improvement of claim 2 where the fiber optic bundle maintains relative spatial relationship between the plurality of cores comprising the fiber optic bundle between the proximal entrance aperture and the distal exit aperture of the optic fiber bundle, and where the OCT system comprises a light source characterized by a coherence length and an objective optics coupling light between the exit aperture of the fiber optic bundle and the sample, the relative spatial relationship of the light focused by the objective optics onto the sample from the distal exit aperture being maintained when focused onto the sample and spatially corresponds to an individual fiber scanning position on the proximal entrance aperture of the fiber optic bundle.

7. The improvement of claim 3 where the scanning optics and each core is characterized by a corresponding numerical aperture, and where the numerical aperture of the scanning optics is less than the numerical aperture of each core in the fiber optic bundle so that only low-order modes are coupled into the fiber optic bundle and propagate in each core.

8. The improvement of claim 1 where the entrance aperture and exit aperture are polished at a predetermined angle to reduce reflection from the entrance aperture and exit aperture.

9. The improvement of claim 8 where the predetermined angle is approximately 8°

inclined relative to a perpendicular aperture face.

10. The improvement of claim 1 where the optic fiber bundle has a predetermined optical length chosen to distance a fundamental mode light image from ghost images which are produced by other modes to avoid any overlap of the fundamental mode light image and ghost image.

11. The improvement of claim 10 where the predetermined optical length is chosen to position the ghost images out of the field of view of the fundamental mode light image.

12. The improvement of claim 2 where the scanner provides a scanning beam characterized by a beam size and where each core is characterized by a fiber core size, where the beam size is less than the fiber core size to improve coupling of the scanning beam into each core during scanning.

13. The improvement of claim 1 further comprising means for improving coupling efficiency between the scanner and fiber optic bundle.

14. The improvement of claim 13 where scanner and the fiber optic bundle are each characterized by a corresponding numerical aperture and where the means for improving coupling efficiency comprises means for matching the numerical aperture of the scanner and the fiber optic bundle, means for optimizing the scanning optics and the objective optics, or means for matching index of refraction between optical component connections between the scanner, fiber optic bundle, and objective optics.

15. The improvement of claim 1 where the OCT system comprises a light source, and an optimized fiber coupler coupled to the light source to deliver increased power to the sample arm from the light source.

16. The improvement of claim 1 further comprising objective optics for optically coupling the exit aperture of the fiber optic bundle into the sample and where the objective optics comprises two graded index (GRIN) lenses to reduce probe diameter.

17. An improvement in a method of operating an OCT system for imaging a sample, the OCT system having a sample arm with a scanner, the improvement comprising:

optically coupling the sample arm through the scanner to a fiber optic bundle through a proximal entrance aperture of the fiber optic bundle; and

optically coupling the fiber optic bundle to the sample through a distal exit aperture of the fiber optic bundle remote from the scanner.

18. The improvement of claim 17 where optically coupling the sample arm through the scanner to a fiber optic bundle comprises coupling the sample arm through the scanner to a plurality of separate single mode or multimode fiber cores by focusing a scanning light beam onto the proximal entrance aperture of the fiber optic bundle.

19. The improvement of claim 17 where optically coupling the fiber optic bundle to the sample comprises focusing light onto the sample from the distal exit aperture of the fiber optic bundle through objective optics.

20. The improvement of claim 18 where coupling the sample arm through the scanner to a plurality of separate single mode or multimode fiber cores comprises:

maintaining relative spatial relationship between the plurality of cores comprising the fiber optic bundle between the proximal entrance aperture and the distal exit aperture of the optic fiber bundle;

providing a light source characterized by a coherence length and an objective optics coupling light between the exit aperture of the fiber optic bundle and the sample; and

maintaining the relative spatial relationship of the light focused by the objective optics onto the sample from the distal exit aperture when focused onto the sample to spatially correspond to an individual fiber scanning position on the proximal entrance aperture of the fiber optic bundle.

21. The improvement of claim 18 where coupling the sample arm through the scanner to a plurality of separate single mode or multimode fiber cores comprises coupling only low-order modes to the plurality of separate single mode or multimode fiber cores and propagating only low-order modes in each core by setting the numerical aperture of the scanning optics to a magnitude less than the numerical aperture of each core in the fiber optic bundle.

22. The improvement of claim 17 further comprising reducing reflections from the entrance aperture and exit aperture by polishing the entrance aperture and exit aperture at a predetermined angle.

23. The improvement of claim 17 further comprising reducing reflections from the entrance aperture and exit aperture by polishing the entrance aperture and exit aperture at an angle of approximately 8°

inclined relative to a perpendicular aperture face.

24. The improvement of claim 17 further comprising distancing a fundamental mode light image from ghost images which are produced by other modes by avoiding any overlap of the fundamental mode light image and ghost image by means of providing a predetermined optical length of the fiber optic bundle.

25. The improvement of claim 24 where distancing a fundamental mode light image from ghost images comprises positioning the ghost images out of the field of view of the fundamental mode light image by means of providing a predetermined optical length of the fiber optic bundle.

26. The improvement of claim 18 where each core is characterized by a fiber core size and where coupling the sample arm through the scanner to a plurality of separate single mode or multimode fiber cores comprises providing a scanning beam characterized by a beam size which is less than the fiber core size to improve coupling of the scanning beam into each core during scanning.

27. The improvement of claim 17 further comprising improving coupling efficiency between the scanner and fiber optic bundle.

28. The improvement of claim 27 where scanner and the fiber optic bundle are each characterized by a corresponding numerical aperture and improving coupling efficiency comprises matching the numerical aperture of the scanner and the fiber optic bundle, optimizing the scanning optics and the objective optics, or matching index of refraction between optical component connections between the scanner, fiber optic bundle, and objective optics.