Optical probe for arterial tissue analysis

• US 20070038124A1
• Filed: 06/02/2006
• Published: 02/15/2007
• Est. Priority Date: 06/02/2005
• Status: Abandoned Application

• Current Assignee: Newton Laboratories, Inc.
• Original Assignee: Newton Laboratories, Inc.
• Inventors: Fulghum, Stephen, Feld, Jonathan, Thimmaraju, Sudha
• Application Number:
  US11/445,923
• Publication Number:
  US 20070038124A1
• Time in Patent Office: Days
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance

Abstract

The present invention relates to systems and methods used in the measurement of arterial tissue. Optical probes in accordance with the invention use optical fibers to deliver and collect light using a sidelooking catheter. Diffused white light and fluorescence scattering is collected and processed to provide for improved artery wall diagnosis.

Claims

1. An optical probe for arterial tissue comprising:

a fiber optic probe having at least one delivery optical fiber and a plurality of collection optical fibers;

a reflective optical element to deliver and collect light in a radial direction at a distal end of the probe;

a first light source to deliver fluorescence excitation light;

a second light source to deliver reflectance light;

a filter element; and

a detector system that detects the fluorescence and reflectance light.

2. The optical probe of claim 1 further comprising a third light source.

3. The optical probe of claim 1 further comprising an optical fiber switch.

4. The optical probe of claim 1 further comprising a filter switch.

5. The optical probe of claim 1 further comprising a data processor that processed fluorescence and reflectance data to provide a diagnostic indicator of fibrous cap thickness.

6. The optical probe of claim 1 wherein the reflective optical element comprises a first reflective surface at a first angle and a second reflective surface at a second angle.

7. The optical probe of claim 1 wherein the reflective optical element comprises a curved surface.

8. The optical probe of claim 1 wherein the reflective optical element comprises a plurality of flat surfaces at different angles.

9. The optical probe of claim 3 wherein the switch comprises a moveable element that couples light from a first light source fiber or a second light source fiber to the delivery fiber.

10. A method of using an optical probe for arterial tissue comprising:

providing a fiber optic probe having at least one delivery optical fiber and a plurality of collection optical fibers;

providing a reflective optical element to deliver and collect light in a radial direction at a distal end of the probe;

coupling light from a first light source to deliver fluorescence excitation light with at least one delivery fiber;

coupling light from a second light source to deliver reflectance light;

providing a filter element; and

detecting fluorescence and reflectance light with the collection optical fibers.

11. The method of claim 10 further comprising providing a third light source.

12. The method of claim 10 further comprising providing an optical fiber switch.

13. The method of claim 10 further comprising providing a filter switch.

14. The method of claim 10 further comprising processing spectral data with a data processor that processed fluorescence and reflectance data to provide a diagnostic indicator of fibrous cap thickness.

15. The method of claim 10 further comprising actuating the optical fiber switch to couple light from a first light source fiber into the delivery optical fiber.

16. The method of claim 15 further comprising actuating the optical fiber switch by moving a fiber coupler to align a second light source fiber into the delivery optical fiber.

17. The method of claim 16 further comprising actuating the optical fiber coupler to align a third light source optical fiber with the delivery fiber.

19. The method of claim 10 further comprising reflecting light with a plurality of surfaces on the reflective optical element, the surfaces being positioned at different angles relative to a longitudinal axis of the distal end of the probe.

20. The method of claim 19 further comprising reflecting light off at least three surfaces in a radial direction.

18. The method of claim 18 further comprising actuating three sources in sequence in less than one second while actuating the optical fiber switch.