Embolectomy procedures with a device comprising a polymer and devices with polymer matrices and supports

• US 20070038226A1
• Filed: 07/27/2006
• Published: 02/15/2007
• Est. Priority Date: 07/29/2005
• Status: Abandoned Application

• Current Assignee: Jason Galdonik, Matthew Ogle
• Original Assignee: Jason Galdonik, Matthew Ogle
• Inventors: Galdonik, Jason, Ogle, Matthew
• Application Number:
  US11/494,783
• Publication Number:
  US 20070038226A1
• Time in Patent Office: Days
• US Class Current: 606/114
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 2017/00778 Operations on blood vessels A61B2017/22097, A61B2017/320741 take precedence
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/320733 with a flexible cutting or scraping element, e.g. with a whip-like distal filament member
• CPC Class Codes: A61B 2017/320741 for stripping the intima or the internal plaque from a blood vessel, e.g. for endarterectomy
• CPC Class Codes: A61B 2217/005 with suction drainage system

Abstract

Embolectomy procedures can be performed under conditions to effectively remove thrombus/emboli with little risk of injuring the vessel wall and while effectively capturing and removing emboli. Desired embolectomy devices present a polymer matrix against the vessel wall. Suction can be used to facilitate the embolectomy process and to remove emboli loosened in the procedure. Some devices combine features to present a polymer matrix against the vessel wall while corresponding providing sufficient support to effectively loosen thrombus. Combinations of embolectomy and/or filter elements can be used.

Claims

1. A method for the removal of thrombus with an embolectomy device comprising a guide structure and a plurality of fibers operably connected to the guide structure, the method comprising moving the embolectomy device within a vessel of a patient to dislodge thrombus with the embolectomy device wherein suction is applied within the vessel to remove at least a portion of the dislodged thrombus.

2. The method of claim 1 wherein the suction is applied for at least a portion of the time while the filter element is moving.

3. The method of claim 1 wherein the suction is applied for the entire time that the filter element is moved.

4. The method of claim 1 wherein the fibers form a three dimensional filtration matrix.

5. The method of claim 1 further comprising applying suction while the embolectomy device is transformed into a recovery configuration and drawing the filter element in its recovery configuration into a distal opening of an aspiration catheter.

6. The method of claim 5 wherein suction is applied for at least a portion of the time when the embolectomy device is brought into the catheter.

7. The method of claim 1 wherein the embolectomy device is moved in a continuous fashion across a region where thrombus is thought to be present.

8. The method of claim 1 further comprising deploying the embolectomy device at a location downstream from a location identified with thrombus.

9. The method of claim 1 wherein the guide structure comprises an integrated guiding structure comprising a corewire within an overtube and further comprising actuating the fibers into a deployed configuration prior to the movement of the embolectomy device to associate thrombus wherein the actuation of the fibers comprises moving of the corewire relative to the overtube.

10. The method of claim 9 further comprising after movement of the embolectomy device to associate thrombus, transitioning the fibers to a recovery configuration through the movement of the corewire relative to the overtube in an opposite direction as used to actuate the fibers.

11. The method of claim 1 wherein the plurality of fibers comprises a bundle of fibers.

12. The method of claim 1 wherein the fibers are associated with a support structure.

13. The method of claim 1 wherein the embolectomy device further comprises a porous filtration sleeve operably connected to the guide structure distal to the fibers.

14. The method of claim 1 further comprising delivering a liquid into the vessel.

15. The method of claim 1 wherein the emboletomy device comprises a bioactive agent.

16. A method for the removal of thrombus with an embolectomy device comprising a guide structure, an embolectomy device comprising a polymer matrix and a filter comprising a three-dimensional filtration matrix having a deployed configuration with the filtration matrix extending across the lumen of a vessel, the method comprising moving the embolectomy device within a vessel of a patient to dislodge thrombus while the filter is in its deployed configuration at a fixed location within the vessel.

17. A biocompatible filtration device comprising a guide structure having a proximal end and a distal end, a three dimensional filtration matrix connected near the distal end of the guide structure and a porous filtration membrane connected to the guide structure distal to the three dimensional filtration matrix.

18. The biocompatible filtration device of claim 17 wherein the guide structure comprises an integrated guide structure having an overtube and corewire extending through the overtube.

19. The biocompatible filtration device of claim 18 wherein the three dimensional filtration matrix changes configuration in response to relative movement of the overtube and the corewire.

20. The biocompatible filtration device of claim 17 wherein the three dimensional filtration matrix comprises a plurality of fibers.

21. The biocompatible filtration device of claim 17 wherein the three dimensional filtration matrix comprises woven fibers.

22. The biocompatible filtration device of claim 17 wherein the three dimensional filtration matrix comprises a hydrogel.

23. The biocompatible filtration device of claim 17 wherein the porous filtration sleeve comprises a polymer or metal sheet with holes through the sheet.

24. The biocompatible filtration device of claim 17 wherein the porous filtration sleeve comprises struts attached proximally to a porous sheet, wherein the struts mediate deployment of the sleeve.

25. The biocompatible filtration device of claim 17 wherein the three dimensional filtration matrix is in contact with a filtration surface of the porous filtration sleeve.

26. A biocompatible filtration device comprising a guide structure having a proximal end and a distal end, a three dimensional filtration matrix connected near the distal end of the guide structure and a support structure interfaced with the three dimensional filtration matrix to form a filter element having a deployed configuration and a recovery configuration, wherein in the deployed configuration the three dimensional filtration matrix extends outward from the support structure with respect to the filtering function of the device relative to the axis of the guide structure.

27. A biocompatible embolectomy device comprising a guide structure having a proximal end and a distal end, a plurality of polymeric fibers connected near the distal end of the guide structure and a support structure wherein the fibers interface with the support structure to reinforce the fibers, wherein the fibers have a deployed configuration and a recovery configuration and wherein in the deployed configuration the polymeric fibers extend outward from the support structure relative to the axis of the guide structure.

28. An embolectomy device comprising a tubular catheter having a distal end and a proximal end with a lumen extending from the proximal end to an aspiration port at or near the distal end, an aspiration apparatus operably connected at or near the proximal end of the tubular catheter and a plurality of fibers connected to the surface of the catheter at a localized section within 10 centimeters from the distal end of the catheter.

29. The embolectomy device of claim 28 wherein the fibers extend outward when unconstrained.

30. The embolectomy device of claim 28 wherein the fibers connect a proximal segment and a distal segment of the catheter and wherein a pullwire connect the proximal end with the distal segment.

31. A method for removing debris from a vessel of a patient, the method comprising sweeping an embolectomy device through a deployed stent within a patient'"'"'s vessel and applying suction to remove debris loosened by the embolectomy device.