Multilayer microperforated implant

• US 20070038299A1
• Filed: 08/12/2005
• Published: 02/15/2007
• Est. Priority Date: 08/12/2005
• Status: Abandoned Application

• Current Assignee: Biomet Sports Medicine LLC (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Arthrotek Incorporated (Zimmer Biomet Holdings, Inc.)
• Inventors: Troxel, Karen, Stone, Kevin
• Application Number:
  US11/203,643
• Publication Number:
  US 20070038299A1
• Time in Patent Office: Days
• US Class Current: 623/11.110
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence

Abstract

A multilayer microperforated implant comprising a plurality of microperforated substrate layers is provided. Methods of forming a microperforated implant comprise providing at least one substrate layer; perforating at least a region of the substrate layer; and dehydrating the substrate layer. Methods of augmenting a site in need of repair with the microperforated implant are also provided.

Claims

1. A multilayer microperforated implant comprising a plurality of microperforated substrate layers, wherein the microperforations have a diameter of less than about 10 micrometers.

2. The multilayer microperforated implant according to claim 1, wherein at least one substrate layer has a punch density of from about 1 to about 1,000 punches per square inch.

3. The multilayer microperforated implant according to claim 1, wherein the substrate layers comprise at least one resorbable material selected from the group consisting of polysaccharides, synthetic polymers, natural polymers, and mixtures thereof.

4. The multilayer microperforated implant according to claim 3, wherein the resorbable material is a polysaccharide selected from the group consisting of hyaluronic acid, chitin, chitosan, alginate, carboxymethylcellulose, and mixtures thereof.

5. The multilayer microperforated implant according to claim 3, wherein the resorbable material is a synthetic polymer selected from the group consisting of polymers and co-polymers of glycolic acid, L-lactic acid, D-lactic acid, urethane urea, trimethylene carbonate, dioxanone, caprolactone, hydroxybutyrate, orthoesters, orthocarbonates, aminocarbonates, and physical combinations thereof.

6. The multilayer microperforated implant according to claim 3, wherein the resorbable materials is a natural polymer selected from the group consisting of collagen, elastin, silk, fibrin, fibrinogen, and mixtures thereof.

7. The multilayer microperforated implant according to claim 6, wherein the natural polymer is collagen and the collagen is porcine derived.

8. The multilayer microperforated implant according to claim 1, wherein at least one substrate layer is a substantially non-resorbable collagen.

9. The multilayer microperforated implant according to claim 1, wherein the implant is dehydrated.

10. The multilayer microperforated implant according to claim 1, wherein at least one microperforation of each substrate layer is in fluid communication with at least one microperforation in an adjacent substrate layer.

11. The multilayer microperforated implant according to claim 1, wherein the microperforations are arranged to direct a hydration media to the inner most substrate layers.

12. The multilayer microperforated implant according to claim 1, wherein the implant is pre-fabricated.

13. The multilayer microperforated implant according to claim 12, wherein the pre-fabricated implant is a cartilage implant, a tendon implant, or a ligament implant.

14. The multilayer microperforated implant according to claim 1, wherein the implant comprises at least 8 layers.

15. A method of forming a microperforated implant comprising:

providing at least one substrate layer;

perforating at least a region of the substrate layer; and

dehydrating the substrate layer.

16. The method according to claim 15, wherein the perforating comprises contacting the substrate layer with a needle to displace less than about 10 micrometers of the material and form an opening.

17. The method according to claim 16, wherein the less than 10 micrometers opening is stretched to a greater diameter without removing additional material.

18. The method according to claim 15, wherein a plurality of substrate layers are stacked together to provide a multilayer microperforated implant.

19. The method according to claim 15, further comprising hydrating the microperforated implant with a hydration fluid such that upon contact with a hydration fluid, the hydration fluid transverses each of the substrate layers.

20. The method according to claim 15, wherein the hydration fluid is selected from the group consisting of water, saline, and blood selected from the group consisting of whole blood, platelet concentrate, and plasma.

21. A method of augmenting a site in need of repair, comprising:

a. providing dehydrated multilayer implant comprising a plurality of resorbable layers, wherein at least one resorbable layer includes perforations having a diameter of less than about 10 micrometers; and

b. placing the implant at a site in need of soft tissue repair.

22. The method according to claim 21, wherein each layer of the multilayer implant includes perforations having a diameter of less than about 10 micrometers.

23. The method according to claim 21, wherein the implant is hydrated with a hydration media selected from the group consisting of water, saline, and blood.