Method and apparatus for detecting biomolecular interactions
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Abstract
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
144 Citations
25 Claims
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1-16. -16. (canceled)
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17. An instrument for detecting light reflected from a surface of a biosensor, said instrument comprising:
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a light source;
an illuminating fiber optically coupled to said light source, said illuminating fiber illuminating an area of said surface of said biosensor;
a detecting fiber for detecting radiation reflected from said surface;
a spectrometer receiving said reflected radiation; and
software determining a peak wavelength value of said reflected radiation. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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25-33. -33. (canceled)
Specification