Dendrimer based compositions and methods of using the same
First Claim
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1. A composition comprising a dendrimer, said dendrimer comprising a GCPII inhibitor.
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Abstract
The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
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19 Claims
- 1. A composition comprising a dendrimer, said dendrimer comprising a GCPII inhibitor.
- 12. A method of targeting a therapeutic agent, an imaging agent or a biological monitoring agent to a cell expressing PSMA in a subject comprising providing a dendrimer comprising a GCPII inhibitor conjugated to said therapeutic agent, said imaging agent or said biological monitoring agent to said subject under conditions such that said dendrimer comprising a GCPII inhibitor interacts with said cell expressing PSMA.
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