Metformin Tablet with Sustained Release and Method for Preparing the Same
First Claim
1. A method for preparing a metformin tablet with sustained release comprising:
- (a) converting a pharmaceutical composition comprising metformin or a pharmaceutically acceptable salt thereof as an active ingredient and a matrix into a slug at a pressure of 5-30 MPa;
(b) granulating said slug into particles with a size of 12-30 meshes and preparing them into a tablet core; and
(c) forming a coated film on the surface of the tablet core.
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Accused Products
Abstract
The present invention relates to a metformin tablet with sustained release and a method for preparing the same, more particularly to an improved metformin tablet with sustained release prepared by manufacturing a composition comprising metformin, which is an active ingredient for treatment of insulin-independent diabetes, and a matrix capable of controlling release rate of metformin into a slug at a given pressure condition, forming a tablet core by dry granulation and then forming a coated film on it, which is slowly released into the body at a constant rate for 24 hours, thereby maintaining a constant blood concentration for 24 hours when administered once a day while offering bioequivalence comparable to that of conventional products, and a method for preparing the same.
22 Citations
9 Claims
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1. A method for preparing a metformin tablet with sustained release comprising:
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(a) converting a pharmaceutical composition comprising metformin or a pharmaceutically acceptable salt thereof as an active ingredient and a matrix into a slug at a pressure of 5-30 MPa;
(b) granulating said slug into particles with a size of 12-30 meshes and preparing them into a tablet core; and
(c) forming a coated film on the surface of the tablet core. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification