Anti-inflammatory activity of phenethylisothiocyanate (PEITC) and the Barbarea verna seed preparation containing this compound

• US 20070042061A1
• Filed: 08/18/2006
• Published: 02/22/2007
• Est. Priority Date: 08/18/2005
• Status: Active Grant

• Current Assignee: Rutgers University
• Original Assignee: Rutgers University
• Inventors: Raskin, Ilya, Ribnicky, David, Dey, Moul
• Granted Patent: US 7,838,045 B2
• Time in Patent Office: Days
• US Class Current: 424/755
• CPC Class Codes: A61K 31/277 having a ring, e.g. verapamil
• CPC Class Codes: A61K 36/31 Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The subject of this invention is the anti-inflammatory activity of a formulation of Barbarea verna (upland cress, early winter cress, or winter cress) seed preparation (BSP) containing phenethylisothiocyanate as its main active ingredient. BSP is a promising anti-inflammatory agent, which can be used for treatment of many inflammation-related conditions, including but not limited to rheumatoid and osteoarthritis, acute and chronic pains, lupus, irritable bowl disease, cancer and metabolic syndrome.

Claims

1. A method of treating an inflammation-related disorder in a mammal comprising the step of:

administering to a subject a therapeutically effective amount of phenethylisothiocyanate.

2. The method of claim 1 wherein the disorder is one of the group of rheumatoid arthritis, asthma, inflammatory bowel disease, Crohn'"'"'s disease, ulcerative colitis, multiple sclerosis, psoriasis and skin rushes, chronic obstructive pulmonary disease, allergic rhinitis, cardiovascular disease, lupus, and metabolic syndrome.

3. The method of claim 1 wherein the phenethylisothiocyanate is administered orally to a subject.

4. The method of claim 1 wherein the administered phenethylisothiocyanate is a formulation of a plant preparation.

5. The method of claim 4 wherein the plant preparation is Barbarea verna seed preparation.

6. The method of claim 5 wherein the seed preparation is an essential oil.

7. The method of claim 4 wherein the plant preparation is a preparation of Barbarea verna seed that has been fortified with the essential oil of Barbarea verna seed.

8. A composition comprising phenethylisothiocyanate, wherein said phenethylisothiocyanate has been prepared from a seed preparation fortified with seed essential oil.

9. The composition of claim 8, wherein the seed preparation comprises ground seed soaked in aqueous liquid.

10. The composition of claim 8, wherein the seed preparation is obtained from a plant of the family Brassicaceae.

11. The composition of claim 10 wherein the composition comprises a preparation of Barbarea verna seed that has been fortified with the essential oil of Barbarea vernia seed.

12. The composition of claim 8 further comprising a pharmaceutically acceptable excipient or carrier.

13. The composition of claim 12 wherein the composition is in a form that can be administered orally.

14. A composition comprising phenethylisothiocyanate, wherein said phenethylisothiocyanate has been prepared from a seed essential oil.