Guided Electrical Transcranial Stimulation (GETS) Technique
First Claim
Patent Images
1. A method of determining an optimal transcranial or intracranial, or other trans-tissue application of electrical energy for therapeutic treatment, comprising:
- (a) obtaining MRI or CAT scan data, or both, of a subject brain or other body tissue;
(b) assigning different anisotropic electrical values to portions of the subject brain or other body tissue based on the data;
(c) selecting electrode sites; and
(d) calculating, based on the assigning and selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial or other trans-tissue electricity.
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Abstract
An optimal transcranial or intracranial application of electrical energy for is determined for therapeutic treatment. MRI or CAT scan data, or both, are obtained for a subject brain. Different electrical resistance values are assigned to portions of the subject brain based on the data. Electrode sites are selected. Based on the assigning and selecting, one or more applied electrical inputs are calculated for optimal therapeutic application of transcranial or intracranial electricity.
157 Citations
80 Claims
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1. A method of determining an optimal transcranial or intracranial, or other trans-tissue application of electrical energy for therapeutic treatment, comprising:
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(a) obtaining MRI or CAT scan data, or both, of a subject brain or other body tissue;
(b) assigning different anisotropic electrical values to portions of the subject brain or other body tissue based on the data;
(c) selecting electrode sites; and
(d) calculating, based on the assigning and selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial or other trans-tissue electricity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of determining an optimal transcranial or intracranial application of electrical energy for therapeutic treatment, comprising:
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(a) obtaining a combination of two or more types of three-dimensional MRI or CAT scan data, or both, of a subject brain;
(b) assigning different electrical values to portions of the subject brain based on the data;
(c) selecting electrode sites including disposing at least one electrode at least partially through the skull; and
(d) calculating, based on the assigning and selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial electricity. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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25. A method of determining an optimal transcranial or intracranial or other trans-tissue application of electrical energy for therapeutic treatment, comprising:
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(a) obtaining MRI or CAT scan data, or both, of a subject brain or other body tissue;
(b) segmenting the subject brain by defining tissue compartment boundaries between, and one or more electrical characteristics to, said portions of the subject brain or other body tissue;
(c) implementing a finite element model by defining a mesh of grid elements for the subject brain or other body tissue;
(d) ascribing electrical values to each of the grid elements based on the segmenting;
(e) selecting electrode sites; and
(f) calculating, based on the ascribing and selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial or other trans-tissue current. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32)
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33. A method of determining an optimal transcranial or intracranial or other trans-tissue application of electrical energy for therapeutic treatment based on MRI or CAT scan data, or both, of a subject brain or other body tissue, and different anisotropic electrical values assigned to portions of the subject brain or other body tissue based on the data, the method comprising:
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(a) selecting electrode sites; and
(b) calculating, based on the assigned anisotropic electrical values and the selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial or other trans-tissue current. - View Dependent Claims (34, 35, 36)
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37. A method of determining an optimal transcranial or intracranial or other trans-tissue application of electrical energy for therapeutic treatment based on obtaining MRI or CAT scan data, or both, of a subject brain or other body tissue, and electrical values ascribed to grid elements of a mesh defined by implementing a finite element model for a subject brain or other body tissue, and by segmenting the subject brain or other body tissue by defining tissue compartment boundaries between, and one or more electrical characteristics to, said portions of the subject brain or other body tissue, and by implementing a finite element model by defining a mesh of grid elements for the subject brain, and ascribing electrical values to each of the grid elements based on the segmenting, the method comprising:
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(a) selecting electrode sites; and
(b) calculating, based on the ascribed electrical values and selecting, one or more applied electrical values for optimal therapeutic application of transcranial or intracranial or other trans-tissue current. - View Dependent Claims (38, 39, 40)
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41. One or more processor readable storage devices having processor readable code embodied thereon, said processor readable code for programming one or more processors to perform a method of determining an optimal transcranial or intracranial or other trans-tissue application of electrical energy for therapeutic treatment, the method comprising:
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(a) obtaining MRI or CAT scan data, or both, of a subject brain or other body tissue;
(b) assigning different anisotropic electrical values to portions of the subject brain or other body tissue based on the data;
(c) selecting electrode sites; and
(d) calculating, based on the assigning and selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial or other trans-tissue electricity. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. One or more processor readable storage devices having processor readable code embodied thereon, said processor readable code for programming one or more processors to perform a method of determining an optimal transcranial or intracranial application of electrical energy for therapeutic treatment, the method comprising:
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(a) obtaining a combination of two or more types of three-dimensional MRI or CAT scan data, or both, of a subject brain;
(b) assigning different electrical values to portions of the subject brain based on the data;
(c) selecting electrode sites including disposing at least one electrode at least partially through the skull; and
(d) calculating, based on the assigning and selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial current. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64)
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65. One or more processor readable storage devices having processor readable code embodied thereon, said processor readable code for programming one or more processors to perform a method of determining an optimal transcranial or intracranial or other trans-tissue application of electrical energy for therapeutic treatment, the method comprising:
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(a) obtaining MRI or CAT scan data, or both, of a subject brain or other body tissue;
(b) segmenting the subject brain or other body tissue by defining tissue compartment boundaries between, and one or more electrical characteristics to, said portions of the subject brain or other body tissue;
(c) implementing a finite element model by defining a mesh of grid elements for the subject brain or other body tissue;
(d) ascribing electrical values to each of the grid elements based on the segmenting;
(e) selecting electrode sites; and
(f) calculating, based on the assigning and selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial or other trans-tissue current. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72)
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73. One or more processor readable storage devices having processor readable code embodied thereon, said processor readable code for programming one or more processors to perform a method of determining an optimal transcranial or intracranial or other trans-tissue application of electrical energy for therapeutic treatment based on MRI or CAT scan data, or both, of a subject brain or other body tissue, and different anisotropic electrical values assigned to portions of the subject brain or other body tissue based on the data, the method comprising:
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(a) selecting electrode sites; and
(b) calculating, based on the assigned anisotropic values and the selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial or other trans-tissue current. - View Dependent Claims (74, 75, 76)
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77. One or more processor readable storage devices having processor readable code embodied thereon, said processor readable code for programming one or more processors to perform a method of determining an optimal transcranial or intracranial or other trans-tissue application of electrical energy for therapeutic treatment based on obtaining MRI or CAT scan data, or both, of a subject brain or other body tissue, and electrical values ascribed to grid elements of a mesh defined by implementing a finite element model for a subject brain or other body tissue, and by segmenting the subject brain or other body tissue by defining tissue compartment boundaries between, and one or more electrical characteristics to, said portions of the subject brain or other body tissue, and by implementing a finite element model by defining a mesh of grid elements for the subject brain or other body tissue, and ascribing electrical values to each of the grid elements based on the segmenting, the method comprising:
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(a) selecting electrode sites; and
(b) calculating, based on the ascribed electrical values and selecting, one or more applied electrical inputs for optimal therapeutic application of transcranial or intracranial or other trans-tissue current. - View Dependent Claims (78, 79, 80)
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Specification