Cryoprobe with reduced adhesion to frozen tissue, and cryosurgical methods utilizing same

• US 20070043342A1
• Filed: 08/16/2005
• Published: 02/22/2007
• Est. Priority Date: 08/16/2005
• Status: Abandoned Application

• Current Assignee: Galil Medical Ltd. (Boston Scientific Corporation)
• Original Assignee: Galil Medical Ltd. (Boston Scientific Corporation)
• Inventors: Kleinberger, Paul
• Application Number:
  US11/204,175
• Publication Number:
  US 20070043342A1
• Time in Patent Office: Days
• US Class Current: 606/21
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/00101 using an array of thermosensors
• CPC Class Codes: A61B 2018/00041 Heating, e.g. defrosting
• CPC Class Codes: A61B 2018/0019 vibrating
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid

Abstract

The present invention relates to devices and methods for cryosurgery. More particularly, the present invention relates to a cryoprobe which does not form strong adhesive or mechanical bonds with body tissues when such tissues are frozen by cooling action of the probe. Embodiments of the present invention include a cryoprobe having a distal cooling module with an outer surface layer of non-polar molecules, a probe having a distal cooling module with a microscopically smooth outer surface, and a cryoprobe comprising a mechanism for coating a distal cooling module thereof with non-polar lubricant during movement of the cryoprobe within body tissues of a patient. Also presented are methods utilizing disclosed cryoprobes to facilitate cryosurgery and to enhance accuracy of cryoablation of user-selected cryoablation targets.

Claims

1. A cryoprobe with reduced tendency to adhere to frozen tissues, comprising one of a group consisting of:

(a) a cooling module having a microscopically smooth external surface;

(b) a cooling module having an external surface comprising non-polar material;

(c) a cooling module coated with a substantially non-polar substance having lubricating qualities at room temperature and when cooled to below-freezing temperatures;

(d) an external orifice through which a biocompatible non-polar substance, delivered to said orifice through communicating with said orifice, may be extruded during movement of said cryoprobe within a body of a patient; and

(e) a mechanical attachment operable to impart small repetitive motions to an inserted cryoprobe while said inserted cryoprobe is cooled to below-freezing temperatures.

2. The cryoprobe of claim 1, having a microscopically smooth external surface comprising non-polar material.

3. The cryoprobe of claim 2, further comprising an external orifice communicating with an internal lumen through which a non-polar substance may be extruded during movement of said cryoprobe within a body of a patient.

4. The cryoprobe of claim 2, further comprising a mechanical attachment operable to impart small repetitive motions to an inserted cryoprobe while said inserted cryoprobe is cooled to below-freezing temperatures.

5. The cryoprobe of claim 1 comprising said mechanical attachment operable to impart small repetitive motions to an inserted cryoprobe while said inserted cryoprobe is cooled to below-freezing temperatures, wherein said repetitive motions are selected from a group consisting of longitudinal movements, rotational movements, and vibratory movements.

6. The cryoprobe of claim 1, comprising a cooling module having an external surface which comprises non-polar material, wherein exposed portions of surface molecules of said external surface are predominantly non-polar.

7. The cryoprobe of claim 1, comprising an external surface which comprises Teflon®

.

8. The cryoprobe of claim 1, comprising said orifice, so designed and constructed that said biocompatible non-polar substance extruded through said orifice while said cryoprobe is inserted into a body of a patient at least partially coats an external surface of a cooling module of said cryoprobe.

9. The cryoprobe of claim 1, comprising said orifice, so designed and constructed that said biocompatible non-polar substance extruded through said orifice while said cryoprobe is withdrawn from a body of a patient at least partially coats an external surface of a cooling module of said cryoprobe.

10. The cryoprobe of claim 1, comprising said orifice and wherein said orifice is positioned distally with respect to at least a portion of a cooling module of said cryoprobe.

11. The cryoprobe of claim 1, comprising said orifice wherein said orifice is positioned proximally with respect to at least a portion of a cooling module of said cryoprobe.

12. A cryoprobe with reduced tendency to adhere to frozen tissues, comprising an external surface designed and constructed to form at most weak chemical and mechanical bonding with ice crystals that form in proximity to said cryoprobe when a cooling module of said cryoprobe is cooled to below-freezing temperatures.

13. A system for cryoablation of a user-selected cryoablation target, comprising:

(a) a cryoprobe navigable within tissues of a body while being cooled to below-freezing temperatures;

(b) a first data source providing real-time data relating to positioning of said cryoprobe with respect to said user-selected cryoablation target;

(c) a second data source providing real-time data relating to temperature of said cryoprobe; and

(d) a controller operable to calculate preferred operating parameters for said cryoprobe as a function of data from said first and second data sources.

14. The system of claim 13 further comprising a servomechanism operable to displace said cryoprobe within a body of a patient according to commands issued by said controller.

15. The system of claim 13 further comprising a cryogen supply operable to supply a controlled amount of fluid cryogen to said cryoprobe according to commands issued by said controller.

16. The system of claim 15, wherein said fluid cryogen is a compressed gas and said cryogen supply is operable to supply a controlled flow of said gas to said cryoprobe.

17. The system of claim 15, wherein said cryogen is a liquefied gas and said cryogen supply is operable to control flow of said liquefied gas to said cryoprobe.

18. The system of claim 13, further comprising:

(a) a servomechanism operable to displace said cryoprobe within a body of a patient according to commands issued by said controller; and

(b) a cryogen supply operable to supply controlled quantities of fluid cryogen to said cryoprobe according to commands issued by said controller.

19. The system of claim 18, wherein said controller is operable to calculate and command speed of movement of said cryoprobe within a body of a patient as a function of temperature of said cryoprobe and further as a function of position of said cryoprobe in relation to said user-selected cryoablation target.

20. The system of claim 18, wherein said controller is operable to calculate and command a rate of supply of cryogen to said cryoprobe as a function of position of said cryoprobe with respect to a user-selected cryoablation target, speed of movement of said cryoprobe, and detected temperature of said cryoprobe.

21. A method for cryotreatment of a patient, comprising:

(a) inserting into tissues of a body of said patient a cryoprobe which comprises an external surface designed and constructed to form at most weak bonds with ice crystals that form in proximity to said cryoprobe when a cooling module of said cryoprobe is cooled to below-freezing temperatures; and

(b) displacing said cryoprobe within said tissues while cooling said cryoprobe to below freezing temperatures.

22. The method of claim 21, further comprising using a control module to calculate cooling parameters and movement parameters for said cryoprobe based on a plurality of data streams.

23. The method of claim 22, where said data streams comprise:

(a) data relating to temperature of said cryoprobe; and

(b) data relating to position of said cryoprobe with respect to a user-selected cryoablation target.

24. A balloon catheter sized for insertion into a body conduit and operable to cool a wall of said body conduit, comprising one of a group consisting of:

(a) a cooling module having a microscopically smooth external surface;

(b) a cooling module having an external surface comprising non-polar material;

(c) a cooling module coated with a substantially non-polar substance having lubricating qualities at room temperature and when cooled to below-freezing temperatures;

(d) an external orifice through which a biocompatible non-polar substance, delivered to said orifice through communicating with said orifice, may be extruded during movement of said cryoprobe within a body of a patient; and

(e) a mechanical attachment operable to impart small repetitive motions to an inserted cryoprobe while said inserted cryoprobe is cooled to below-freezing temperatures.