Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures
First Claim
1. A method of determining a neural stimulation threshold for a patient comprising the steps of:
- applying a test stimulation signal to the patient;
monitoring the patient for a response to the test stimulation signal;
determining a first neural stimulation threshold corresponding to a lowest intensity test stimulation signal that evokes a patient response; and
calculating a second neural stimulation threshold based upon the first neural stimulation threshold, the second neural stimulation threshold corresponding to a treatment stimulation signal directed toward affecting a neural activity within the patient.
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Abstract
Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
176 Citations
53 Claims
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1. A method of determining a neural stimulation threshold for a patient comprising the steps of:
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applying a test stimulation signal to the patient;
monitoring the patient for a response to the test stimulation signal;
determining a first neural stimulation threshold corresponding to a lowest intensity test stimulation signal that evokes a patient response; and
calculating a second neural stimulation threshold based upon the first neural stimulation threshold, the second neural stimulation threshold corresponding to a treatment stimulation signal directed toward affecting a neural activity within the patient. - View Dependent Claims (2, 3, 4)
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5. A method of determining a neural stimulation threshold for a patient comprising the steps of:
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applying a plurality of limited duration test stimulation signals to the patient;
monitoring the patient for a response to a test stimulation signal; and
determining a first neural stimulation threshold corresponding to a lowest intensity test stimulation signal that evokes a patient response. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of determining a neural stimulation threshold for a patient comprising the steps of:
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applying a plurality of test stimulation signals to the patient;
monitoring the patient for a response to a test stimulation signal; and
determining a first neural stimulation threshold corresponding to a lowest intensity test stimulation signal that evokes a patient response, wherein successive test stimulation signals applied to the patient are temporally separated by a minimum time interval. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 31)
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30. A method of determining a neural stimulation threshold for a patient comprising the steps of:
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selecting a set of test stimulation signal parameters that reduce a likelihood of inducing seizure activity in the patient;
applying a plurality of test stimulation signals to the patient;
monitoring the patient for a response to a test stimulation signal;
determining a first neural stimulation threshold corresponding to a lowest intensity test stimulation signal that evokes a patient response; and
calculating a second neural stimulation threshold based upon the first neural stimulation threshold, the second neural stimulation threshold corresponding to a treatment stimulation signal directed toward affecting neural activity within the patient, wherein the treatment stimulation signal differs from at least one test stimulation signal with respect to a plurality of parameters.
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32. A neuro-stimulation system comprising:
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a stimulus unit configured to deliver a set of test stimulation signals to a patient; and
a controller operatively coupled to the stimulus unit, the controller including a computer operable medium containing instructions that define a set of parameters corresponding to each test stimulation signal and at least one from the group of a maximum duration corresponding to each test stimulation signal and a minimum time interval between at least two test stimulation signals. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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Specification