Defibrillation threshold prediction methods and systems

• US 20070043395A1
• Filed: 08/22/2005
• Published: 02/22/2007
• Est. Priority Date: 08/22/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Wei, Xuan, Bocek, Joseph, Zhang, Yi, Meyer, Scott, Sweeney, Robert, Stahmann, Jeffrey
• Granted Patent: US 7,711,425 B2
• Time in Patent Office: Days
• US Class Current: 607/8
• CPC Class Codes: A61N 1/3943 for threshold determination

Abstract

A nondefibrillating and nonfibrillation-inducing energy is delivered at a first internal thoracic location. A first resulting electrical signal is detected at a second internal thoracic location in or near a target region of a heart. A first defibrillation threshold is estimated using the nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength. The defibrillation threshold represents an energy that when delivered at the first internal thoracic location creates an electric field strength in the target region of the heart that meets or exceeds the target electric field strength.

Claims

1. A method comprising:

delivering a first nondefibrillating and nonfibrillation-inducing energy at a first internal thoracic location;

detecting a first resulting electrical signal at a second internal thoracic location in or near a target region of a heart, the first resulting electrical signal providing an indication of a first electric field strength in the target region; and

estimating a defibrillation threshold using the first nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength at the target region of the heart.

2. The method of claim 1, wherein the second internal thoracic location is in or near the target region.

3. The method of claim 1, wherein delivering a first nondefibrillating and nonfibrillation-inducing energy includes delivering the energy at a location in or near the heart.

4. The method of claim 1, wherein delivering a first nondefibrillating and nonfibrillation-inducing energy includes delivering the energy at a subcutaneous location outside the heart.

5. The method of claim 1, wherein delivering a first nondefibrillating and nonfibrillation-inducing energy includes delivering the energy at a location in or near a right region of the heart;

and

detecting a first resulting electrical signal includes detecting the signal at a location in or near a left region of the heart.

6. The method of claim 5, wherein detecting a first resulting electrical signal includes detecting the signal at a location in or near a left apical region of the heart.

7. The method of claim 5, wherein detecting a first resulting electrical signal includes detecting a signal at a location in or near a left ventricular free lateral wall of the heart.

8. The method of claim 1, wherein detecting a first resulting electrical signal at a second internal thoracic location in or near a target region of a heart includes obtaining at least two potential gradient vectors using at least three electrodes, and estimating the defibrillation threshold includes:

combining the at least two potential gradient vectors to obtain a combined potential gradient value; and

using the combined potential gradient value to estimate the defibrillation threshold.

9. The method of claim 1, wherein detecting a first resulting electrical signal includes detecting the first resulting electrical signal using electrodes of a bipolar lead in or near the left side of the heart.

10. The method of claim 1, further comprising delivering a notification if the estimated defibrillation threshold meets or exceeds at least one of a specified value or a specified change in value.

11. The method of claim 1, further comprising adjusting a defibrillation therapy energy to meet or exceed the first defibrillation threshold.

12. The method of claim 1, further comprising:

delivering a second nondefibrillating and nonfibrillation-inducing energy at the first internal thoracic region; and

detecting a second resulting electrical signal at a third internal thoracic location in or near the target region;

wherein the estimating a defibrillation threshold includes using both the first resulting electrical signal and the second resulting electrical signal to estimate the defibrillation threshold.

13. The method of claim 1, further comprising:

delivering a second nondefibrillating and nonfibrillation-inducing energy at the first internal thoracic region; and

detecting a second resulting electrical signal at a third internal thoracic location in or near the target region;

wherein the estimating a defibrillation threshold includes using a smaller of the first resulting electrical signal and the second resulting electrical signal.

14. The method of claim 1, wherein detecting a first resulting electric signal includes sensing an electrical signal through a guide wire.

15. The method of claim 1, wherein delivering a first nondefibrillating and nonfibrillation-inducing energy includes delivering the energy during a specified portion of a cardiac cycle or respiratory cycle.

16. The method of claim 1, wherein detecting a first resulting electrical signal includes detecting the first resulting electrical signal during a specified portion of a cardiac cycle or respiratory cycle.

17. The method of claim 1, wherein estimating a defibrillation threshold includes separating from the first resulting electrical signal at least one intrinsic electrical signal and using a resulting remainder of the resulting electrical signal to estimate the defibrillation threshold.

18. A method comprising:

delivering a first nondefibrillating and nonfibrillation-inducing energy at a first internal thoracic location;

detecting a first resulting electrical signal at a second internal thoracic location in or near a target region of a heart, the first resulting electrical signal providing an indication of a first electrical field strength in the target region; and

estimating a first defibrillation threshold using the first nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength;

delivering a second nondefibrillating and nonfibrillation-inducing energy at the first internal thoracic location;

detecting a second resulting electrical signal at the second internal thoracic location, the second resulting electrical signal providing an indication of a second electric field strength in the target region of the heart during delivery of the second nondefibrillating and nonfibrillation-inducing energy;

determining a change in a defibrillation threshold using the first resulting electrical signal and the second resulting electrical signal.

19. The method of claim 18, wherein determining a change in the defibrillation threshold includes:

estimating a second defibrillation threshold for the target region of the heart using the indication of a second electric field strength and the second energy; and

determining a change in a defibrillation threshold using the second defibrillation threshold and the first defibrillation threshold.

20. The method of claim 18, wherein determining a change in the defibrillation threshold includes comparing the second resulting electrical signal and the first resulting electrical signal.

21. The method of claim 18, further comprising delivering a notification if the second defibrillation threshold exceeds at least one of the first defibrillation threshold by a specified amount or a specified change from first defibrillation threshold.

22. The method of claim 18, further comprising detecting a physiological parameter using at least one other physiologic sensor;

and

delivering a notification or adjusting a defibrillation therapy if the physiological parameter meets a specified criteria the second defibrillation threshold exceeds at least one of the first defibrillation threshold by a specified amount or a specified change from first defibrillation threshold.

23. A method comprising:

delivering a first nondefibrillating and nonfibrillation-inducing energy to a thorax using a first defibrillation configuration;

detecting a first resulting electrical signal at a internal thoracic location in or near a target region of a heart, the first resulting electrical signal providing an indication of a first electric field strength in the target region;

delivering a second nondefibrillating and nonfibrillation-inducing energy to the thorax using a second defibrillation configuration;

detecting a second resulting electrical signal at the internal thoracic location, the second resulting electrical signal providing an indication of a second electric field strength in the target region of the heart during delivery of the nondefibrillating and nonfibrillation-inducing energy using the second defibrillation configuration;

estimating at least one defibrillation threshold using at least one target electric field strength and at least one of the first and second resulting electrical signals.

24. The method of claim 23, wherein delivering a first nondefibrillating and nonfibrillation-inducing energy to a thorax using a first defibrillation configuration includes delivering the energy through a plurality of electrodes, and

delivering a second nondefibrillating and nonfibrillation-inducing energy to the thorax using a second defibrillation configuration includes changing a configuration of the plurality of electrodes and then delivering the energy through the plurality of electrodes.

25. The method of claim 24, wherein changing a configuration of the plurality of electrodes includes changing a location of at least one electrode.

26. The method of claim 24, wherein changing a configuration of the plurality of electrodes includes electrically connecting at least one electrode to at least one other electrode.

27. The method of claim 23, wherein delivering a first nondefibrillating and nonfibrillation-inducing energy includes delivering an energy, voltage, or current using at least one electrode, and

delivering a second nondefibrillating and nonfibrillation-inducing energy includes delivering a different energy, voltage, or current using the at least one electrode.

28. The method of claim 23, wherein delivering a first nondefibrillating and nonfibrillation-inducing energy includes delivering the first nondefibrillating and nonfibrillation-inducing energy using a first electrode configuration, and

delivering a second nondefibrillating and nonfibrillation-inducing energy includes delivering the second nondefibrillating and nonfibrillation-inducing energy using a second electrode configuration;

and

estimating at least one defibrillation threshold selecting an electrode configuration that produces a smaller defibrillation threshold for delivery of an antitachyarrhythmia therapy therefrom.

29. A system comprising:

an energy module adapted to deliver a nondefibrillating and nonfibrillation-inducing energy using at least a first electrode at a first internal thoracic location;

a response signal module adapted to detect a resulting signal using at least a second electrode at a second internal thoracic location in or near a target region of a heart, the responsive signal resulting from the delivery of the energy and providing an indication of an electric field strength at the second internal thoracic location; and

a controller communicatively coupled to the energy module and the response signal module, the controller adapted to estimate a defibrillation threshold using the nondefibrillating and nonfibrillation-inducing energy and the resulting signal.

30. The system of claim 29, further comprising the first electrode, the second electrode, the response signal module adapted to detect a voltage between the second electrode and a third electrode at a location in or on the left side of the heart at a known or estimated distance from the second electrode.

31. The system of claim 30, wherein the second and third electrode are shaped and configured for implantation in or on a left apical region of the heart or a left ventricular free lateral wall.

32. The system of claim 29, further comprising a lead positionable in a coronary vessel in the left side of the heart, wherein the response signal module is adapted to detect resulting signals at multiple points in the coronary vessel, and the controller is adapted to estimate a defibrillation threshold using the responsive signals detected by the response signal module.

33. The system of claim 29, wherein the controller is adapted to compare a detected resulting signal with a previous detected resulting signal to detect a change in the resulting signal indicative of a defibrillation threshold change, physiological change, posture change, or lead dislodgement.

34. The system of claim 29, wherein the controller is adapted to compare an estimated defibrillation threshold to a previously estimated defibrillation threshold to detect a change in the defibrillation threshold.

35. The system of claim 34, wherein the controller is adapted to deliver a notification if an changed defibrillation threshold is detected.

36. The system of claim 34, wherein the controller is adapted to increase an energy level of an antitachyarrhythmia therapy if an increased defibrillation threshold is detected.

37. The system of claim 29, wherein the controller is configured to change an electrode configuration, estimate a second defibrillation threshold for at least a second electrode configuration, compare estimated defibrillation thresholds for at least two electrode configurations, and select a defibrillation electrode configuration using the estimated defibrillation thresholds.

38. The system of claim 29, further including an intrinsic heart signal sensing circuit, the controller communicatively coupled to the intrinsic heart signal sensing circuit and adapted to deliver the energy at a specified portion of a cardiac cycle or respiratory cycle.

39. The system of claim 29, further including an intrinsic heart signal sensing circuit, the controller communicatively coupled to the intrinsic heart signal sensing circuit and adapted to detect the resulting electric signal at a specified portion of a cardiac cycle or respiratory cycle.

40. The system of claim 29, further comprising the first electrode and the second electrode.

41. The system of claim 29, wherein the first internal thoracic region is in or near the right side of the heart and the second internal thoracic region is in or near the left side of the heart.