Methods and devices for analysis of x-ray images
First Claim
Patent Images
1. A method to derive quantitative information on bone structure from a dental x-ray image comprising:
- (a) obtaining a dental x-ray image, wherein the dental x-ray image includes (i) at least a portion of the maxilla or mandible and (ii) an external standard for determining bone structure; and
(b) analyzing the image obtained in step (a) to derive quantitative information on bone structure.
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Abstract
The present invention relates to methods and devices for analyzing x-ray images. In particular, devices, methods and algorithms are provided that allow for the accurate and reliable evaluation of bone structure from x-ray images.
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Citations
50 Claims
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1. A method to derive quantitative information on bone structure from a dental x-ray image comprising:
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(a) obtaining a dental x-ray image, wherein the dental x-ray image includes (i) at least a portion of the maxilla or mandible and (ii) an external standard for determining bone structure; and
(b) analyzing the image obtained in step (a) to derive quantitative information on bone structure.
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2. A method to derive quantitative information on bone structure from an x-ray image comprising:
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(a) obtaining an x-ray image; and
(b) analyzing the image obtained in step (a) using one or more indices selected from the group consisting of Hough transform, skeleton operator, morphological operators, mean pixel intensity, variance of pixel intensity, fourier spectral analysis, fractal dimension, morphological parameters and combinations thereof, thereby deriving quantitative information on bone structure.
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3. An x-ray assembly for determining bone mineral density or bone structure comprising
(a) a hygienic cover; -
(b) x-ray film and (d) a calibration phantom comprising at least one marker positioned in an area of known density or structure. - View Dependent Claims (4)
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5. A kit comprising a hygienic cover;
- a calibration phantom for bone structure or bone density comprising an integrated geometric pattern;
an x-ray imaging assembly and computer programs, wherein said computer programs analyze and assess bone mineral density or bone structure.
- a calibration phantom for bone structure or bone density comprising an integrated geometric pattern;
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6. An x-ray assembly for determining bone mineral density or bone structure comprising
(a) a hygienic cover; -
(b) x-ray film and (d) a calibration phantom for measuring bone mineral density or structure or combinations thereof.
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7. A method of treating a bone condition comprising
(a) obtaining an image from a subject; -
(b) analyzing the image obtained in step (a) to derive quantitative information on bone structure;
(c) diagnosing a bone condition based on the analysis of step (b); and
(d) selecting and administering a suitable treatment to said subject based on said diagnosis.
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8. A method of determining bone mineral density from an x-ray image, the method comprising the steps of
(a) determining density of one or more internal standards in said image; -
(b) creating a weighted mean between the values obtained in step (a);
(c) utilizing said weighted mean to determine bone mineral density of bone in said image.
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9. A method of determining bone structure from an x-ray image comprising the steps of
(a) identifying one or more internal standards on said x-ray image; -
(b) determining the density or structure of said standard; and
(c) utilizing the density, structure or combinations thereof of said standard to determine bone structure of the x-ray image.
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10. A method of evaluating bone disease in a subject, the method comprising the steps of:
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(a) obtaining an x-ray image from said subject, wherein said image includes one or more bones;
(b) assessing bone mineral density in at least one anatomic region of said image;
(c) assessing bone structure in said region; and
(d) combining said assessments of bone mineral density and bone structure to evaluate bone disease.
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11. A method of treating bone disease in a subject, the method comprising the steps of:
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(a) obtaining an image from said subject, wherein said image includes one or more bones;
(b) assessing bone mineral density in at least one anatomic region of said image;
(c) assessing bone structure in said region;
(d) combining said assessments of bone mineral density and bone structure to evaluate bone disease;
(e) selecting a therapy based on the evaluation of bone disease; and
(f) administering said therapy to said subject.
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12. A method for evaluating bone disease in a subject, the method comprising the steps of:
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(a) obtaining an image of said subject wherein said image includes one or more bones;
(b) assessing bone structure of said bone in said image;
(c) assessing one or more macro-anatomical parameters in said image; and
(d) combining the assessments bone structure and macro-anatomical parameter assessment to evaluate bone disease.
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13. A method for minimizing tube angulation of an x-ray tube that includes an x-ray film holder, comprising the steps of
providing an attachment mechanism; - and
attaching the x-ray system to the x-ray film holder such that tube angulation is minimized.
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14. A method for minimizing tube angulation of an x-ray tube that includes a dental x-ray film holder, comprising the steps of
providing an x-ray tube alignment system; - and
aligning the x-ray system substantially perpendicular to the x-ray film such that tube angulation is minimized, wherein said alignment system uses optical aids.
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15. A method of treating a bone condition comprising
(a) obtaining an image from a subject; -
(b) analyzing the image obtained in step (a) to derive quantitative information on bone structure;
(c) diagnosing a bone condition based on the analysis of step (b); and
(d) selecting and administering a suitable treatment to said subject based on said diagnosis. - View Dependent Claims (16, 17, 18, 19)
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20. A method of determining bone mineral density from an x-ray image, the method comprising the steps of
(a) determining density of one or more internal standards in said image; -
(b) creating a weighted mean between the values obtained in step (a);
(c) utilizing said weighted mean to determine bone mineral density of bone in said image. - View Dependent Claims (21)
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22. A method of determining bone structure from an x-ray image comprising the steps of
(a) identifying one or more internal standards on said x-ray image; -
(b) determining the density or structure of said standard; and
(c) utilizing the density, structure or combinations thereof of said standard to determine bone structure of the x-ray image. - View Dependent Claims (23)
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24. A method of evaluating bone disease in a subject, the method comprising the steps of:
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(a) obtaining an x-ray image from said subject, wherein said image includes one or more bones;
(b) assessing bone mineral density in at least one anatomic region of said image;
(c) assessing bone structure in said region; and
(d) combining said assessments of bone mineral density and bone structure to evaluate bone disease. - View Dependent Claims (25, 26, 27, 28, 29, 30)
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31. A method of treating bone disease in a subject, the method comprising the steps of:
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(a) obtaining an image from said subject, wherein said image includes one or more bones;
(b) assessing bone mineral density in at least one anatomic region of said image;
(c) assessing bone structure in said region;
(d) combining said assessments of bone mineral density and bone structure to evaluate bone disease;
(e) selecting a therapy based on the evaluation of bone disease; and
(f) administering said therapy to said subject. - View Dependent Claims (32, 33)
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34. A method for evaluating bone disease in a subject, the method comprising the steps of:
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(a) obtaining an image of said subject wherein said image includes one or more bones;
(b) assessing bone structure of said bone in said image;
(c) assessing one or more macro-anatomical parameters in said image; and
(d) combining the assessments bone structure and macro-anatomical parameter assessment to evaluate bone disease. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41)
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42. A method for minimizing tube angulation of an x-ray tube that includes an x-ray film holder, comprising the steps of
providing an attachment mechanism; - and
attaching the x-ray system to the x-ray film holder such that tube angulation is minimized.
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- 43. The method of claim 43, wherein said x-ray film bolder includes a Rinn instrument.
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47. A method for minimizing tube angulation of an x-ray tube that includes a dental x-ray film holder, comprising the steps of
providing an x-ray tube alignment system; - and
aligning the x-ray system substantially perpendicular to the x-ray film such that tube angulation is minimized, wherein said alignment system uses optical aids. - View Dependent Claims (48, 49, 50)
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Specification