Carbon dioxide nanosensor, and respiratory CO2 monitors

• US 20070048181A1
• Filed: 07/18/2006
• Published: 03/01/2007
• Est. Priority Date: 09/05/2002
• Status: Abandoned Application

• Current Assignee: Nanomix Incorporated (CJY Holdings Ltd.)
• Original Assignee: Nanomix Incorporated (CJY Holdings Ltd.)
• Inventors: Chang, Daniel, Chang, Ying-Lan, Mickelson, William, Valcke, Christian, Star, Alexander, Joshi, Vikram, Niemann, Joseph, Gabriel, Jean-Christophe, Passmore, John
• Application Number:
  US11/488,456
• Publication Number:
  US 20070048181A1
• Time in Patent Office: Days
• US Class Current: 422/57
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: G01N 27/4146 involving nanosized elements, e.g. nanotubes, nanowires
• CPC Class Codes: G01N 33/004 for CO, CO2
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

An electronic system and method for detecting analytes, such as carbon dioxide, is provided, using an improved nanostructure sensor (CO2 sensor). The CO2 sensor may comprise a substrate and a nanostructure, such as a one or more carbon nanotubes disposed over the substrate (e.g., as a network). One or more conductive elements may electrically communicate with the nanostructure. A counter or gate electrode may be positioned adjacent the nanostructure. A functionalization material reactive with carbon dioxide may be included, either disposed in contact with the nanostructure or isolated by a dielectric. The sensor may be connected to a circuit responsive to changes in CO2 concentration in the environment. Embodiments are described of medical sensing systems including one or more CO2 sensors. One embodiment comprises a breath sampling cannula which is connected to a sensor unit. In an alternative, the cannula permits supplemental oxygen to be administered, while recovering and measuring analytes in breath samples. The cannula may connect to a portable processor-display unit for monitoring one or more analytes, such as CO2. Another embodiment includes a cannula configured for the monitoring of sleep disorders, such as apnea, comprising one or more sensors disposed adjacent a breath sampling channel, optionally including flow rate or other sensors. The sensors may be connected by wired or wireless links for to a processor/input/display unit. Any of the embodiments may include filters, selectively permeable membranes, absorbents, and the like to precondition the breath sample, may be configured to include complementary chemistry measurements.

Claims

1. A nanostructure sensor for sensing carbon dioxide, comprising:

a substrate;

a first nanostructure disposed adjacent the substrate;

one or more conducting elements in electrical communication with the first nanostructure; and

at least one recognition material operatively associated with the first nanostructure, the at least one recognition material configured for interacting with carbon dioxide.

2. A nanostructure sensor as in claim 1, wherein the recognition material is in direct contact with the nanostructure.

3. A nanostructure sensor as in claim 1, wherein the recognition material is in isolated from the nanostructure by a dielectric layer.

4. A nanostructure sensor as in claim 3, wherein the dielectric layer is less than about 500 nm thick.

5. A nanostructure sensor as in claim 4, wherein the dielectric layer is between about 50 nm and 1 nm.

6. A nanostructure sensor as in claim 5, wherein the dielectric layer is between about 30 nm and 5 nm.

7. A nanostructure sensor as in claim 3, wherein the dielectric layer is deposited by atomic layer deposition (ALD).

8. A nanostructure sensor as in claim 7, further including at least a second layer deposited by ALD having material properties distinct from the dielectric layer.

9. A nanostructure sensor as in claim 8, wherein the second layer includes a recognition material configured for interacting with carbon dioxide.

10. A nanostructure sensor as in claim 1, wherein the recognition material further comprises an aqueous solution capable of reacting with carbon dioxide.

11. A nanostructure sensor as in claim 10, wherein the recognition material comprises an accelerator configured to catalyze the conversion of aqueous carbon dioxide to carbonic acid.

12. A nanostructure sensor as in claim 11, wherein the accelerator comprises carbonic anhydrase.

13. A breath analyzer system comprising:

a breath sampling cannula including one or more lumens configured to by mounted adjacent at least one of a patient'"'"'s nostril and mouth, the lumen having an opening arranged to gather an exhaled breath sample upon patient exhalation;

one or more nanostructure sensor comprised as in claim 1, the sensor in communication with the lumen of the breath sampling cannula, so as to contact at least a portion of the exhaled breath sample;

the sensor have a sensitivity carbon dioxide (CO₂) in human exhaled breath so at to produce a sensor signal in response to the breath species;

a processing unit in communication with the sensor so as to receive the sensor signal, the processor unit configured to use the signal to determine a measurement of one of;

(i) the concentration of CO2 in the sample; and

(ii) the amount of CO2 in the sample, and

an output device in communication with the processing unit and configured to output at least the measurement to a user, so as to provide information related to a human medical state.

14. A breath analyzer comprising:

one or more first sensors comprised as in claim 1 having a sensitivity for carbon dioxide;

at least one second sensor having a sensitivity for at least one second non-carbon-dioxide species found in human exhaled breath, and wherein the concentration of carbon dioxide and the second species in human exhaled breath has a correlation with a human medical state;

a breath sampler configured to sample at least the exhaled breath of a patient, and in communication with the first and second sensors;

a prcoessor system in communication with the first and second sensors and configured to measure the concentration of carbon dioxide and the second species, and to the measurements to a user, so as to provide information related to the human medical state.