Multi-channel pipette device

• US 20070048188A1
• Filed: 08/26/2004
• Published: 03/01/2007
• Est. Priority Date: 09/26/2003
• Status: Abandoned Application

• Current Assignee: Hirschmann Laborgeräte GmbH & Co. KG
• Original Assignee: Hirschmann Laborgeräte GmbH & Co. KG
• Inventors: Bigus, Hans
• Application Number:
  US10/572,849
• Publication Number:
  US 20070048188A1
• Time in Patent Office: Days
• US Class Current: 422/100
• CPC Class Codes: B01L 2400/0439 ultrasonic vibrations, vibrating piezo elements
• CPC Class Codes: B01L 3/021 Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
• CPC Class Codes: B01L 3/0241 Drop counters; Drop formers making arrays for combinatorial libraries B01J19/0046; automation of dispensing for analysis G01N35/10
• CPC Class Codes: F04B 43/043 Micropumps
• CPC Class Codes: G01N 35/1072 with provision for selective pipetting of individual channels
• CPC Class Codes: G01N 35/1074 arranged in a two-dimensional array

Abstract

A pipette device comprising a plurality of multi-channels which are arranged in one or several rows or like a matrix in several rows and columns and which are connected to the tip of a pipette on the end side thereof. At least one separate micromembrane pump is associated with each pipette channel for dosed suction or discharge of fluids, said pump consisting of several disk-type microstructures which are placed on top of each other and between which a pump chamber is formed and wherein one of which is provided with a membrane which can be deformed by an actuating element. In order to provide an extremely user-friendly pipette device which can be constructed in a simple, economical manner, at least some of the micromembrane pumps of different pipette channels are connected to each other in a material fit and the micromembrane pumps of each of said pipette channels can be programmed separately from each other by means of an electronic data processing unit such that the dosing volume of each micromembrane pump can be adjusted separately.

Claims

1-14. -14. (canceled)

15. A pipette device for dosed suctioning and/or discharge of fluids through a plurality pipette tips, the device comprising:

a dosing head defining a plurality of pipette channels disposed in one or more rows or in a matrix of rows and columns, each channel for connection to one pipette tip;

a plurality of micro-membrane pumps, wherein at least some of said micro-membrane pumps are connected to each other in material fit, with each pipette channel cooperating with at least one micro-membrane pump for pumping and suctioning the fluids, the micro-membrane pumps comprising a first and a second substantially, disk-shaped member, disposed one on top of the other to define an intermediate pump chamber, wherein at least one of said first and said second disk-shaped members defines a membrane;

a plurality of actuating elements cooperating with said membranes to deform said membranes during pumping and/or suctioning; and

electronic data processing means communicating with said actuating elements to separately adjust a pumping volume of each membrane pump.

16. The pipette device of claim 15, wherein said substantially disk-shaped microstructures of said micro-membrane pumps comprise a semi-conductor material, silicon, or an alloy containing silicon.

17. The pipette device of claim 15, wherein said actuating elements comprise at least one piezoelectric, electromagnetic, electrostatic, or thermo-pneumatic drive means.

18. The pipette device of claim 15, wherein a group of said micro-membrane pumps in rows or columns or in a matrix are connected to each other with material fit.

19. The pipette device of claim 15, wherein all of said micro-membrane pumps are connected to each other in material fit.

20. The pipette device of claim 15, wherein an air cushion is provided between the fluid in a pipette channel and an associated micro-membrane pump.

21. The pipette device of claim 15, wherein each of said pipette channel has two associated said micro-membrane pumps which can be separately actuated and which have one connection on a suction side and one connection on a pressure side, wherein said pipette channel is connected to said pressure side connection of one said micro-membrane pump and said suction side connection of an other micro-membrane pump.

22. The pipette device of claim 21, wherein one of said micro-membrane pumps is connected to surroundings on said pressure side and said other micro-membrane pump is connected to surroundings on said suction side.

23. The pipette device of claim 21, wherein said pressure and suction side connections of said micro-membrane pumps comprise check valves.

24. The pipette device of claim 15, wherein each pipette channel has an associated micro-membrane pump having two openings which can be closed by two separately controlled valves, wherein said pipette channel is connected to one of said two openings.

25. The pipette device of claim 24, wherein said valves of said micro-membrane pumps have a drive mechanism that corresponds to a drive mechanism of said membrane.

26. The dosing head of the pipette device of claim 15.

27. A computer program product for controlling said electronic data processing means of claim 15, said data processing means having a user interface which permits input of individual dosing volumes for each pump or for groups of pumps, wherein the program generates a signal for each dosing volume which can be transmitted to a processor, such that the processor individually drives each pump with a respective input dosing volume.

28. The computer program product of claim 27, wherein said user interface reproduces said pipette channels of said dosing head of the pipette device disposed in a row or rows or like a matrix in rows and columns.