Surface-modified medical devices and methods of making
First Claim
1. A surface-treated medical device comprising a hydrophilic coating polymer that comprises units of at least a hydrophilic monomer and units of a silane coupling agent, wherein an untreated medical device has a plurality of medical-device surface functional groups, and the silane coupling agent has at least a coupling functional group that is capable of interacting with the medical-device surface functional groups.
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Accused Products
Abstract
A surface-modified medical device comprises a hydrophilic coating that comprises units of a hydrophilic monomer and a coupling agent that has coupling functional groups, at least a portion of which is coupled to the surface functional groups of the medical device. A method for producing such a surface-modified medical device comprises forming the hydrophilic coating by coupling units of the hydrophilic monomer to the medical device through the coupling agent. Medical devices, such as stents, implants, catheters, and ophthalmic devices, are included.
51 Citations
33 Claims
- 1. A surface-treated medical device comprising a hydrophilic coating polymer that comprises units of at least a hydrophilic monomer and units of a silane coupling agent, wherein an untreated medical device has a plurality of medical-device surface functional groups, and the silane coupling agent has at least a coupling functional group that is capable of interacting with the medical-device surface functional groups.
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14. A surface-treated medical device comprising a hydrophilic coating polymer that comprises units of at least a hydrophilic monomer and units of a silane coupling agent, each having a polymerizable group;
- wherein an untreated medical device has a plurality of medical-device surface functional groups, and the silane coupling agent has at least a coupling functional group that is capable of interacting with the medical-device surface functional groups;
the medical-device surface functional groups and the coupling functional group are complementary and are selected from the group consisting of alkoxysilanes, halosilanes, vinylsilanes, allylsilanes, aminoalkylsilanes, glycidylsilanes, fluoroalkylsilanes, mercaptoalkylsilanes, carboxysilanes, isocyanatosilanes, ureidosilanes, hydroxyl, alkoxy, glycidyl, mercapto, carboxyl, amino, isocyanate, and ureido; and
the polymerizable group is selected from the group consisting of vinyl, allyl, acryloyl, acryloyloxy, methacryloyl, methacryloyloxy, epoxide, isocyanate, isothiocyanate, amino, hydroxyl, alkoxy, mercapto, anhydride, carboxylic, fumaryl, styryl, itaconyl, maleimido, methacrylamido, acrylamido, and combinations thereof. - View Dependent Claims (15, 16)
- wherein an untreated medical device has a plurality of medical-device surface functional groups, and the silane coupling agent has at least a coupling functional group that is capable of interacting with the medical-device surface functional groups;
- 17. A polymer comprising at least units of a hydrophilic monomer and units of a silane coupling agent having at least a free coupling functional group.
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25. A method for making a medical device that has a hydrophilic coating, said method comprising:
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(a) providing the medical device having a plurality of medical-device surface functional groups;
(b) providing a coating polymer that comprises units of at least a hydrophilic monomer and units of a silane coupling agent that has coupling functional groups capable of interacting with at least a portion of the medical-device surface functional groups; and
(c) contacting the medical device with the coating polymer to couple the coating polymer to the surface of the medical device. - View Dependent Claims (26, 27)
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28. A method for making a medical device that has a hydrophilic coating, said method comprising:
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(a) providing the medical device having a plurality of medical-device surface functional groups;
(b) providing at least a hydrophilic monomer having a polymerizable group and at least a silane coupling agent having a polymerizable group; and
(c) contacting the medical device with the hydrophilic monomer and the silane coupling agent simultaneously to form the hydrophilic coating.
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29. The method of claim 29, further comprising the step of treating the medical device to increase a population of the medical-device surface functional groups.
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31. A method for making a medical device that has a hydrophilic coating, said method comprising:
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(a) contacting the medical device having a plurality of medical-device surface functional groups with at least a silane coupling agent having at least a coupling functional group and at least a first reactive functional group, the coupling functional group being capable of interacting with the medical-device surface functional groups, producing the medical device having attached coupling agent;
(b) providing a hydrophilic coating polymer comprising units of at least a hydrophilic monomer and a second monomer that has a second reactive functional group that is capable of reacting with the first reactive functional group; and
(c) contacting the medical device having attached coupling agent with the hydrophilic coating polymer to form the hydrophilic coating on the medical device. - View Dependent Claims (30, 32)
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33. The method of claim 35, wherein the step of treating the medical device comprises exposing the medical device to a corona discharge or a plasma discharge treatment.
Specification