General purpose electrolyte solution composition for iontophoresis

• US 20070048362A1
• Filed: 08/29/2006
• Published: 03/01/2007
• Est. Priority Date: 08/29/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: Transcutaneous Technologies, Inc.
• Inventors: Nakayama, Mizuo, Matsumura, Akihiko, Matsumura, Takehiko, Akiyama, Hidero
• Application Number:
  US11/512,756
• Publication Number:
  US 20070048362A1
• Time in Patent Office: Days
• US Class Current: 424/449
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

A single electrolyte solution composition may be used in an anode side and in a cathode side of an iontophoresis device. The electrolyte solution may include a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, both a component that is likely to be relatively reduced and a component that is likely to be relatively oxidized.

Claims

1. A general purpose electrolyte solution for an iontophoresis device, comprising:

a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, a component likely to be relatively reduced and a component likely to be relatively oxidized.

2. The general purpose electrolyte solution composition according to claim 1, further comprising polyacrylic acid and/or lactic acid as a component that imparts a buffering action.

3. The general purpose electrolyte solution composition according to claim 1 wherein the compound comprises a component that oxidizes at a potential lower than the oxidation potential of water, and a component that reduces at a potential higher than the reduction potential of water are included in combination.

4. The general purpose electrolyte solution composition according to claim 3, further comprising polyacrylic acid and/or lactic acid as a component that imparts a buffering action.

5. The general purpose electrolyte solution composition according to claim 1, further comprising:

a component that imparts a buffering action;

wherein no substantial chemical reaction occurs between the components when an electric potential is not applied to the general purpose electrolyte solution; and

wherein the composition causes substantially no harm to a subject.

6. The general purpose electrolyte solution composition according to claim 5, further comprising polyacrylic acid and/or lactic acid as a component that imparts a buffering action.

7. The general purpose electrolyte solution composition according to claim 1 wherein the component likely to be relatively oxidized comprises an ascorbate, and the component likely to be relatively reduced comprises a fumarate.

8. The general purpose electrolyte solution composition according to claim 7, further comprising polyacrylic acid and/or lactic acid as a component that imparts a buffering action.

9. A gel matrix composition comprising a gel that includes a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, a component likely to be relatively reduced and a component likely to be relatively oxidized.

10. The gel matrix composition according to claim 9, further comprising polyacrylic acid and/or lactic acid as a component that imparts a buffering action.

11. The gel matrix composition according to claim 9, further comprising:

a component that imparts a buffering action;

wherein no substantial chemical reaction occurs between the components when an electric potential is not applied to the general purpose electrolyte solution; and

wherein the composition causes substantially no harm to a subject.

14. The gel matrix composition according to claim 9 wherein the electrode assembly further comprises a component that imparts a buffering action wherein no substantial chemical reaction occurs between the components when an electric potential is not applied to the general purpose electrolyte solution;

and wherein the composition causes substantially no harm to a subject.

12. An iontophoresis device, comprising:

an electrode assembly that includes a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, a component likely to be relatively reduced and a component likely to be relatively oxidized.

13. The iontophoresis device according to claim 12 wherein the electrode assembly further comprises polyacrylic acid and/or lactic acid as a component that imparts a buffering action.

15. The iontophoresis device according to claim 12 wherein the electrode assembly is an active electrode assembly comprising an active agent.

16. The iontophoresis device according to claim 12 wherein the electrode assembly is a counter electrode assembly.

17. The iontophoresis device according to claim 12, further comprising:

a power source coupled to the electrode assembly.