CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS
First Claim
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1. An isolated receptor polypeptide comprising amino acid residues 33-662 of SEQ ID NO:
- 5, wherein the receptor polypeptide forms a heterodimeric or multimeric receptor polypeptide with a second receptor polypeptide comprising amino acid residues 28-979 of SEQ ID NO;
7.
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Abstract
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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Citations
13 Claims
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1. An isolated receptor polypeptide comprising amino acid residues 33-662 of SEQ ID NO:
- 5, wherein the receptor polypeptide forms a heterodimeric or multimeric receptor polypeptide with a second receptor polypeptide comprising amino acid residues 28-979 of SEQ ID NO;
7. - View Dependent Claims (2, 3, 4)
- 5, wherein the receptor polypeptide forms a heterodimeric or multimeric receptor polypeptide with a second receptor polypeptide comprising amino acid residues 28-979 of SEQ ID NO;
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5. An isolated soluble receptor polypeptide comprising amino acid residues 33-532 of SEQ ID NO:
- 5, wherein the soluble receptor polypeptide forms a soluble heterodimeric or multimeric receptor polypeptide with a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
7. - View Dependent Claims (6, 7, 8, 9, 10)
- 5, wherein the soluble receptor polypeptide forms a soluble heterodimeric or multimeric receptor polypeptide with a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
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11. A composition comprising:
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a soluble receptor polypeptide comprising amino acid residues 33-532 of SEQ ID NO;
5, wherein the soluble receptor polypeptide forms a soluble heterodimeric or multimeric receptor polypeptide with a second soluble receptor polypeptide comprising amino acid residues 28-739 of SEQ ID NO;
7; and
a pharmaceutically acceptable vehicle. - View Dependent Claims (12, 13)
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Specification