NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION
First Claim
1. A method of treating a nervous system disorder related to cellular degeneration, a psychiatric condition, cellular trauma and/or injury, or another neurologically related condition in a subject or patient, said method comprising administering a muscarinic agent, optionally in combination with another muscarinic agent and/or another neurogenic agent, to produce an improvement in said disorder in said subject or patient.
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Abstract
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via inhibition of acetylcholine esterase (AChE) activity, alone or in combination with another neurogenic agent to stimulate or activate the formation of new nerve cells.
202 Citations
26 Claims
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1. A method of treating a nervous system disorder related to cellular degeneration, a psychiatric condition, cellular trauma and/or injury, or another neurologically related condition in a subject or patient, said method comprising
administering a muscarinic agent, optionally in combination with another muscarinic agent and/or another neurogenic agent, to produce an improvement in said disorder in said subject or patient.
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12. A method of preparing cells or tissue for transplantation to a subject or patient, said method comprising
contacting said cell or tissue with a muscarinic agent, optionally in combination with another muscarinic agent and/or another neurogenic agent, to stimulate or increase neurogenesis in said cell or tissue.
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13. A method of stimulating or increasing neurogenesis in a cell or tissue, said method comprising
contacting said cell or tissue with a muscarinic agent, optionally in combination with another muscarinic agent and/or another neurogenic agent, wherein the muscarinic agent, or combination, is effective to produce neurogenesis in said cell or tissue.
Specification