Method and apparatus for in vivo sensing

• US 20070049845A1
• Filed: 05/26/2006
• Published: 03/01/2007
• Est. Priority Date: 05/27/2005
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Roy, Shuvo, Talman, James, Fleischman, Aaron
• Granted Patent: US 7,284,442 B2
• Time in Patent Office: Days
• US Class Current: 600/561
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/02014 Determining aneurysm
• CPC Class Codes: A61B 5/07 Endoradiosondes
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: H04W 84/18 Self-organising networks, e.g. ad-hoc networks or sensor networks

Abstract

Systems and methods for in vivo sensing are provided. An excitation signal is produced, having a first frequency component and a second frequency component. The first frequency component is swept through a plurality of excitation frequencies within a frequency range of interest.. A response signal is received from an in vivo sensor. The response signal includes a mix component having a frequency equal to one of a sum of a first excitation frequency associated with the first frequency component and a second excitation frequency associated with the second frequency component and a difference between the first and second excitation frequencies. The mix component is evaluated to determine a resonant frequency of the in vivo sensor.

Claims

1. A method for in vivo sensing, comprising the steps of:

producing an excitation signal, having a first frequency component and a second frequency component, wherein a first excitation frequency associated with the first frequency component is swept through a plurality of excitation frequencies within a frequency range of interest;

receiving a response signal from an in vivo sensor, the response signal comprising a mix component having a frequency equal to one of a sum of a first excitation frequency associated with the first frequency component and a second excitation frequency associated with the second frequency component and a difference between the first and second excitation frequencies; and

evaluating the mix component to determine a characteristic of the in vivo sensor.

2. The method of claim 1, wherein the step of evaluating the mix component comprises the step of determining a frequency associated with a maximum amplitude of the mix component.

3. The method of claim 2, wherein the step of evaluating the mix component further comprises the step of calculating an associated capacitance of the in vivo sensor.

4. The method of claim 2, wherein the step of evaluating the mix component further comprises the step of calculating an associated impedance of the in vivo sensor.

5. The method of claim 1, wherein the step of evaluating the mix component further comprises the step of determining a peak width associated with the mix component.

6. The method of claim 5, wherein the step of evaluating the mix component further comprises the step of calculating an associated quality factor of the in vivo sensor.

7. The method of claim 1, further comprising maintaining the second excitation frequency at a fixed offset from the first excitation frequency, such that the difference between the first and second excitation frequencies is constant.

8. The method of claim 1, wherein producing an excitation signal comprises producing an excitation signal of sufficient power to change an electrical characteristic of a nonlinear element associated with the in vivo sensor.

9. The method of claim 8, evaluating the mix component comprises determining a value for the first excitation frequency at which the electrical characteristic of the nonlinear element is changed.

10. The method of claim 8, wherein the nonlinear element is a diode and the change in the electrical characteristic comprises a decrease in electrical resistance due to a forward bias voltage across the diode.

11. A computer program product, encoded on a computer readable medium and operative in a data processing system, for controlling an RF probe, comprising:

a frequency selector that selects a first excitation frequency and a second excitation frequency for the probe;

an amplitude detector that, for each of a plurality of selected values for the first excitation frequency, determines an associated power of a mix component, having an associated frequency equal to one of a sum of the first and second excitation frequencies and a difference between the first and second excitation frequencies, of a response signal from an in vivo sensor to record a frequency response for the signal; and

a response analyzer that evaluates the recorded frequency response to determine a characteristic of the in vivo sensor.

12. The computer program product of claim 11, wherein the frequency selector selects the first and second excitation frequencies such that their sum remains constant.

13. The computer program product of claim 11, wherein the frequency selector selects the first and second excitation frequencies such that the difference between the first and second excitation frequencies remains constant.

14. An RF probe assembly for determining a characteristic of an in vivo sensor having an associated nonlinear element, comprising:

a transmit element that provides an excitation signal for the probe, the excitation signal comprising a first frequency component, having a first associated frequency, and a second frequency component, having a second associated frequency;

a response element that receives a response signal from the in vivo sensor, the response signal comprising a mix component having a frequency equal to one of a sum of the first and second frequencies and a difference between the first and second frequencies; and

a system control that evaluates the mix component to determine the characteristic of the associated in vivo sensor.

15. The RF probe assembly of claim 14, wherein the first and second frequencies are maintained at a constant difference in frequency and the assembly further comprises a bandpass filter operative to isolate the mix component and a lock-in amplifier that amplifies the mix component.

16. The RF probe assembly of claim 14, the system control comprising an arbitrary waveform generator that controls the transmit element as to provide the excitation element and a network analyzer that evaluates the mix component.

17. The RF probe assembly of claim 14, the in vivo sensor comprising a pressure sensor and the determined characteristic of the in vivo sensor comprising the impedance.

18. The RF probe assembly of claim 14, the transmit and response element comprising a pair of orthogonal coils.

19. The RF probe assembly of claim 14, the transmit element being operative to produce a excitation signal of sufficient power to induce a voltage within the in vivo sensor large enough to alter an electrical property of the nonlinear element when the first excitation frequency has a value equal to the value of a resonant frequency associated with the in vivo sensor.

20. The RF probe assembly of claim 19, wherein the nonlinear element is a diode, and the induced voltage drives the diode into forward bias, such that the electrical resistance of the diode is sharply reduced.