Eye-safe photocosmetic device

• US 20070049910A1
• Filed: 08/08/2006
• Published: 03/01/2007
• Est. Priority Date: 08/08/2005
• Status: Abandoned Application

• Current Assignee: Palomar Medical Technologies Incorporated (Hologic Incorporated)
• Original Assignee: Palomar Medical Technologies Incorporated (Hologic Incorporated)
• Inventors: Gaal, Christopher, Altshuler, Gregory, Lopez, Robert, Zenzie, Henry, Wang, Guangming
• Application Number:
  US11/500,588
• Publication Number:
  US 20070049910A1
• Time in Patent Office: Days
• US Class Current: 606/9
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/308 with suction cups
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/00458 Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
• CPC Class Codes: A61B 2018/00476 Hair follicles
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61B 90/04 Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery protection of eyes against laser radiation A61F9/022

Abstract

Devices and methods for treating tissue with radiation, including light and other optical radiation, in a manner that is eye-safe are described. In one embodiment, a photocosmetic treatment device has a cavity into which tissue to be treated is drawn. The device determines whether the tissue is safe to treat and whether the tissue may be tissue associated with the eyes, such as an eyelid. In another embodiment, an eye-safe pulse of radiation is provided at a time interval prior to treatment of the tissue. The pulse is at a wavelength of radiation that the human eye perceives as particularly intense and uncomfortable, even though the pulse is not dangerous or destructive. If the device is oriented to treat eye tissue, directly or through the eyelid, the pulse will cause an aversive reaction in the subject being treated that inhibits the treatment.

Claims

1. A method for treating a tissue of a subject with radiation in an eye-safe manner, comprising:

irradiating said tissue with an eye-safe radiation having a wavelength and intensity chosen to cause an aversive response by said subject when said eye-safe radiation irradiates said subject'"'"'s eye;

waiting a predetermined period of time; and

irradiating said tissue with a treatment radiation when said aversive response does not occur within said period of time;

wherein said tissue is not irradiated with said treatment radiation when said aversive response does occur within said period of time.

2. The method of claim 1, wherein said eye-safe radiation has a wavelength in the range of 600-680 nm.

3. The method of claim 1, wherein said eye-safe radiation has a wavelength that is predominately red.

4. The method of claim 1, wherein said eye-safe radiation has an intensity in the range of 1-10 mW/cm².

5. The method of claim 1, wherein said period of time is in the range of approximately 0.1 to 3.0 seconds.

6. The method of claim 1, wherein said period of time is in the range of approximately 1.0 to 2.0 seconds.

7. The method of claim 1, further comprising determining whether said aversive response has occurred.

8. The method of claim 7, further comprising inhibiting the transmission of said treatment radiation when said aversive response has occurred.

9. The method of claim 1, further comprising contacting said tissue with an applicator to transmit said eye-safe radiation.

10. The method of claim 9, wherein said tissue is irradiated with said eye-safe radiation only if said applicator is in contact with said tissue.

11. The method of claim 9, wherein said tissue is irradiated with said treatment radiation only if said applicator is in contact with said tissue.

12. The method of claim 1, further comprising orienting an applicator to irradiate said tissue with said eye-safe radiation.

13. The method of claim 12, wherein said tissue is irradiated with said eye-safe radiation only if said applicator is in proximity of said tissue.

14. The method of claim 12, wherein said tissue is irradiated with said treatment radiation only if said applicator is in proximity of said tissue.

15. An apparatus for treating tissue with radiation in an eye-safe manner, comprising:

a controller for controlling the production of radiation and configured to provide first and second control signals;

a first radiation source configured to produce in response to said first control signal an eye-safe radiation at an intensity that irritates a subject'"'"'s eye;

a second radiation source configured to produce in response to said second control signal a treatment radiation;

a radiation transmission path configured to transmit radiation from said first radiation source to said tissue through a radiation transmission surface;

a sensor in electrical communication with said controller and configured to provide a sensor signal when said radiation transmission surface is in proximity to said tissue;

wherein said controller is configured to provide said second control signal after a predetermined time interval following said first control signal and when said sensor signal indicates that said radiation transmission surface remains in proximity to said tissue.

16. The apparatus of claim 15, wherein said first radiation source is a diode.

17. The apparatus of claim 15, wherein said first radiation source is configured to produce radiation in the range of 600-680 nm.

18. The apparatus of claim 15, wherein said first radiation source is configured to produce radiation having a wavelength that is predominately red.

19. The apparatus of claim 15, wherein said first radiation source is configured to produce radiation having an intensity in the range of 1-10 mW/cm².

20. The apparatus of claim 15, wherein said predetermined time interval is in the range of approximately 0.1 to 3.0 seconds.

21. The apparatus of claim 15, wherein said predetermined time interval is in the range of approximately 1.0 to 2.0 seconds.

22. The apparatus of claim 15, wherein said controller is configured to provide said second control signal when said radiation transmission surface is in contact with said tissue.

23. The apparatus of claim 15, wherein said controller is configured to provide said first control signal when said radiation transmission surface is in contact with said tissue.

24. The apparatus of claim 15, wherein said sensor is configured to detect an aversive response from said subject in response to said eye-safe radiation.

25. The apparatus of claim 15, wherein said aversive response is one of squinting, pupil dilation, eye movement, head movement, and arm movement.

26. The apparatus of claim 15, wherein said first radiation source is further configured to provide sensor radiation, and wherein said sensor is a detector configured to detect said sensor radiation.

27. The apparatus of claim 26 wherein said sensor radiation has a wavelength in the near infrared range.

28. The apparatus of claim 26 wherein said detector is configured to provide said sensor signal when said sensor radiation exceeds a first predetermined threshold.

29. The apparatus of claim 26, wherein said radiation transmission path is configured to substantially totally internally reflect said sensor radiation when said radiation transmission surface is not in contact with said tissue.

30. The apparatus of claim 15, wherein said radiation transmission path is configured to substantially totally internally reflect said eye-safe radiation when said radiation transmission surface is not in contact with said tissue.

31. The apparatus of claim 15, wherein said radiation transmission path is configured to substantially totally internally reflect said treatment radiation when said radiation transmission surface is not in contact with said tissue.

32. The apparatus of claim 15, wherein said radiation transmission path further comprises:

a first waveguide section;

a second waveguide section; and

a diffuser;

wherein said first waveguide section is located between said first source and said diffuser and said second waveguide section is located between said diffuser and said radiation transmission surface.

33. The apparatus of claim 32, wherein said diffuser extends across substantially the entire said radiation transmission path.

34. The apparatus of claim 32, wherein said diffuser is made of at least one of plastic, glass, and sapphire.

35. The apparatus of claim 32, wherein said second waveguide section is sapphire.

36. The apparatus of claim 32, wherein said second waveguide section includes a cooling mechanism configured to cool said tissue.

37. The apparatus of claim 15, wherein said radiation transmission path includes a cooling mechanism configured to cool said tissue.

38. The apparatus of claim 15, wherein said radiation transmission path is made substantially of sapphire.

39. The apparatus of claim 15, wherein said radiation transmission path includes a diffuser extending across a portion of said radiation transmission path and oriented to diffuse radiation produced by said second radiation source.

40. An apparatus for treating tissue with radiation in an eye-safe manner, comprising:

a radiation source assembly in electrical communication with a controller;

a waveguide configured to transmit radiation from said radiation source assembly to said tissue;

a sensor in electrical communication with said controller and configured to provide a sensor signal when said radiation transmission surface is in proximity to said tissue;

wherein said radiation source assembly is configured to provide in response to signals from said controller a first radiation that is eye-safe and of an intensity capable of causing an aversive reaction from a subject when irradiating the subject'"'"'s eye, a second radiation that is capable of treating said tissue, said second radiation being provided a predetermined time after said first radiation when said sensor indicates that said waveguide remains in proximity of said tissue.

41. The apparatus of claim 40, wherein said radiation source assembly is further configured to provide a third radiation, wherein said sensor is configured to detect said third radiation and issue a sensor signal based on the level of radiation detected.

42. The apparatus of claim 40, wherein said waveguide further includes a diffuser extending across a portion of said waveguide and oriented to diffuse radiation produced by said radiation source assembly.

43. The apparatus of claim 40, wherein said waveguide includes a cooling mechanism configured to cool said tissue.

44. The apparatus of claim 40, wherein said sensor is configured to provide a sensor signal only when said radiation transmission surface is in contact with said tissue.

45. An apparatus for photocosmetic treatment of a subject'"'"'s tissue comprising:

a pressure source;

a cavity having an open end, said cavity in fluid communication with said pressure source, and said open end configured to receive said tissue when said pressure source applies pressure;

at least one radiation source configured to transmit radiation into said cavity; and

a sensor configured to issue a sensor signal;

wherein said sensor signal prevents the transmission of radiation from said radiation transmission source when said sensor detects tissue that is not suitable for treatment.

46. The apparatus of claim 45, wherein said radiation source is configured to transmit radiation from at least two different directions within said cavity.

47. The apparatus of claim 45, wherein said radiation source is configured to treat a set of two or more volumes of tissue each separated by untreated tissue.

48. The apparatus of claim 45, wherein said radiation source is configured to provide radiation to an array of independent treatment sites within said cavity, wherein each such treatment site is separated by untreated tissue within said cavity.

49. The apparatus of claim 45, wherein said sensor is a pressure sensor.

50. The apparatus of claim 45, wherein said sensor is a depth sensor configured to sense a depth of said tissue within said cavity.

51. The apparatus of claim 50, wherein said sensor is configured to provide a control signal inhibiting the transmission of radiation by said radiation source when said tissue extends beyond a predetermined depth into said cavity.

52. The apparatus of claim 45, wherein said sensor is a radiation intensity sensor.

53. The apparatus of claim 52, wherein said radiation intensity sensor is configured to provide a control signal inhibiting the transmission of radiation by said radiation source when said radiation exceeds a predetermined threshold.

54. The apparatus of claim 52, wherein said radiation intensity sensor is configured to provide a control signal inhibiting the transmission of radiation by said radiation source when said radiation is substantially totally internally reflected.

55. The apparatus of claim 45, wherein said apparatus is configured to operate within a predetermined safety ratio.

56. The apparatus of claim 45, wherein said cavity has a depth that is greater than the depth of a target in said tissue to be treated from the surface of said tissue to be treated.

57. The apparatus of claim 45, wherein said cavity has a side that is less than four times the depth of a target in said tissue to be treated from the surface of said tissue to be treated.

58. The apparatus of claim 45, wherein said radiation source is configured to irradiate said tissue at a fluence of about 0.1 to about 100 J/cm².

59. The apparatus of claim 45, wherein said radiation source is configured to irradiate said tissue at a pulse width of about 1 ms to about 500 ms.

60. The apparatus of claim 45, wherein said radiation source is configured to irradiate said tissue at a wavelength range of between approximately 400-1350 nm.

61. The apparatus of claim 45, wherein said radiation source is configured to irradiate said tissue at a wavelength range of between approximately 600-1200 nm.

62. A method for photocosmetic treatment of a subject'"'"'s tissue comprising:

drawing a volume of said tissue into a cavity;

determining whether said volume of tissue is safe to treat using radiation; and

treating said volume of tissue with radiation based on said determination;

wherein said volume of tissue is not treated if it is determined that said tissue is unsafe to treat, and wherein said volume of tissue is treated if it is determined that said tissue is safe to treat.

63. The method of claim 62, wherein said treating includes transmitting radiation from at least two different directions.

64. The method of claim 63, wherein said radiation from at least two different directions overlaps at one or more targets on the skin.

65. The method of claim 63, wherein said radiation from at least two different directions treats a set of two or more volumes of tissue each surrounded by untreated tissue.

66. The method of claim 62, further comprising providing an array of independent treatment sites within said volume of tissue, wherein each such treatment site is separated by untreated tissue within said volume.

67. The method of claim 62, wherein said step of determining further comprises sensing a pressure applied to said tissue.

68. The method of claim 67, wherein said tissue is safe to treat if said pressure exceeds a predetermined threshold.

69. The method of claim 62, wherein said step of determining further comprises sensing the depth of said volume of said tissue within said cavity.

70. The method of claim 69, wherein said tissue is not safe to treat if said volume exceeds a predetermined depth within said cavity.

71. The method of claim 62, wherein said step of determining further comprises sensing radiation using a radiation intensity sensor.

72. The method of claim 71, wherein said tissue is not safe to treat when said radiation exceeds a predetermined threshold.

73. The method of claim 71, wherein said tissue is not safe to treat when said radiation is substantially totally internally reflected.

74. The method of claim 62, wherein said step of determining further comprises determining a ratio of a rise in temperature of the skin versus a rise in temperature of the target, and inhibiting the transmission of radiation with said ratio is not within predetermined limits.

75. The method of claim 62, wherein said step of treating further comprises irradiating said tissue at a fluence of about 0.1 to about 100 J/cm².

76. The method of claim 62, wherein said step of treating further comprises irradiating said tissue with a pulse width of about 1 ms to about 500 ms.

77. The method of claim 62, wherein said step of treating further comprises irradiating said tissue with at least one wavelength in the range of between approximately 400-1350 nm.

78. The method of claim 62, wherein said step of treating further comprises irradiating said tissue with at least one wavelength in the range of between approximately 600-1200 nm.