Multiple unit dose drug delivery system
First Claim
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1. A drug delivery device comprising:
- a housing configured to contain one or more ampoules comprising an active-ingredient-containing substance in a compartment, wherein the ampoules comprise a piercable region in the compartment;
a firing mechanism effective to apply pressure to an ampoule effective to cause the ampoule to be pierced at the piercable region and to release the substance under pressure through the piercable region of the compartment;
a delivery device configured to direct the released substance to the eye, nasal passage, or ear canal of a user;
a mechanically advantaged mechanism whereby a user positions the device into a ready to fire configuration; and
a mechanically advantaged firing control whereby a user activates the firing mechanism to release the substance from the ampoule.
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Abstract
The present disclosure is directed to devices that administer single or multiple doses of one or more substances to the eye, nose, or ear of a user. The precise and repeatable dosing features of the presently disclosed devices overcome many of the disadvantages associated with known methods for dispensing substances to, for example, the eye of a user. The devices administer precise doses of a substance to a precise location from ampoules that may be single-dose or two-dose ampoules, which may be externally or internally pierced.
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Citations
55 Claims
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1. A drug delivery device comprising:
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a housing configured to contain one or more ampoules comprising an active-ingredient-containing substance in a compartment, wherein the ampoules comprise a piercable region in the compartment;
a firing mechanism effective to apply pressure to an ampoule effective to cause the ampoule to be pierced at the piercable region and to release the substance under pressure through the piercable region of the compartment;
a delivery device configured to direct the released substance to the eye, nasal passage, or ear canal of a user;
a mechanically advantaged mechanism whereby a user positions the device into a ready to fire configuration; and
a mechanically advantaged firing control whereby a user activates the firing mechanism to release the substance from the ampoule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 23, 24, 25)
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22. A ophthalmic drug delivery device comprising:
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a housing configured to contain one or more ampoules comprising an ophthalmic drug in a compartment, wherein the ampoules comprise a piercable region in the compartment;
a firing mechanism effective to apply pressure to an ampoule effective to cause the ampoule to be pierced at the piercable region and to release the drug under pressure through the piercable region of the compartment;
a delivery device configured to direct the released drug to the eye of a user;
a mechanically advantaged mechanism whereby a user positions the device into a ready to fire configuration; and
a mechanically advantaged firing control whereby a user activates the firing mechanism to release the drug from the ampoule. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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48. An intranasal drug delivery device comprising:
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a housing configured to contain one or more ampoules comprising a substance adapted for intranasal delivery in a compartment, wherein the ampoules comprise a piercable region in the compartment;
a firing mechanism effective to apply pressure to an ampoule effective to cause the ampoule to be pierced at the piercable region and to release the substance under pressure through the piercable region of the compartment;
a nozzle configured to direct the released substance to the nasal passage of a user;
a mechanically advantaged mechanism whereby a user positions the device into a ready to fire configuration; and
a mechanically advantaged firing control whereby a user activates the firing mechanism to release the substance from the ampoule. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55)
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Specification