Ramipril formulation
First Claim
Patent Images
1. A Ramipril formulation which disintegrates in less than 15 minutes in the USP disintegration test carried out over the anticipated viscosity range in the stomach and which disintegrates in less than 3 minutes in water in the USP disintegration test.
1 Assignment
0 Petitions
Accused Products
Abstract
A Ramipril formulation rapidly disintegrates after ingestion and exhibits substantially no food effect.
55 Citations
15 Claims
- 1. A Ramipril formulation which disintegrates in less than 15 minutes in the USP disintegration test carried out over the anticipated viscosity range in the stomach and which disintegrates in less than 3 minutes in water in the USP disintegration test.
- 3. A Ramipril containing formulation giving dissolution of Ramipril in vivo which is sufficiently rapid that presence or absence of food in the gastrointestinal tract does not substantially alter absorption of the Ramipril.
-
8. An oral Ramipril formulation which does not exhibit a food effect.
-
11. A Ramipril formulation which disintegrates in less than 3 minutes in a model for high agitation in a fasted state, in less than 15 minutes in a model for high agitation in a fed state, and in less than 30 minutes in a model for low agitation in a fed state.
-
14. A kit, comprising
a container, an oral dosage form of Ramipril that does not exhibit a food effect, and written matter non-limited as to whether the dosage form can be taken with or without food.
Specification