Methods for treating temporal lobe epilepsy, associated neurological disorders, and other patient functions
First Claim
1. A method for treating a patient, comprising:
- identifying a target neural site at a parahippocampal gyrus of a patient;
implanting an electrode at a subdural location at least proximate to the target neural site; and
at least reducing both ictal and interictal epileptogenicity of the patient, including interictal neural dysfunction associated with epileptogenicity, by applying electrical signals to the target neural site via the electrode on a generally continual basis both ictally and interictally at a frequency of from about 0.9 Hz to about 250 Hz.
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Accused Products
Abstract
Methods for treating temporal lobe epilepsy, associated neurological disorders, and other patient functions are disclosed. Methods for treating patients in accordance with several embodiments include implanting a signal delivery device subdurally proximate to a target neural site at a cortical location of a patient. The method can further include applying electrical signals to the target neural site via the signal delivery device, on a generally continual basis at a frequency of from about 0.9 Hz to about 250 Hz. The electrical signals can be applied to epileptic patients to at least reduce ictal and interictal epileptic senicity, and/or to patients functioning at normal or better levels to improve patient functioning.
157 Citations
43 Claims
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1. A method for treating a patient, comprising:
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identifying a target neural site at a parahippocampal gyrus of a patient;
implanting an electrode at a subdural location at least proximate to the target neural site; and
at least reducing both ictal and interictal epileptogenicity of the patient, including interictal neural dysfunction associated with epileptogenicity, by applying electrical signals to the target neural site via the electrode on a generally continual basis both ictally and interictally at a frequency of from about 0.9 Hz to about 250 Hz. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for treating a patient, comprising:
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implanting an electrical signal delivery device proximate to a target neural site located at a temporal lobe of a patient; and
at least reducing non-epileptogenic symptoms of the patient by applying electrical signals to the target neural site via the electrical signal delivery device on a generally continual basis at a frequency of from about 0.9 Hz to about 250 Hz. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. A method for treating a patient, comprising:
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implanting an electrical signal delivery device subdurally proximate to a target neural site at a cortical location of a patient; and
improving a non-epileptogenic neurological characteristic of the patient by applying electrical signals to the target neural site via the electrical signal delivery device on a generally continual basis at a frequency of from about 0.9 Hz to about 250 Hz. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method for treating a patient, comprising:
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identifying a target cortical neural site associated with a function that a patient performs at normal or better levels;
implanting an electrical signal delivery device at a subdural location proximate to the target cortical neural site;
improving the function of the patient by applying electrical signals to the target neural site via the electrical signal delivery device on a generally continual basis at a frequency of from about 0.9 Hz to about 250 Hz;
receiving automated feedback from the patient corresponding to the function; and
changing a location at which the signals are provided, based at least in part on the automated feedback. - View Dependent Claims (38, 39, 40, 41, 42, 43)
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Specification