Polyethylene glycol/polycation block copolymers
First Claim
1. A polyethylene glycol/polycation block copolymer characterized by having segment A formed of polyethylene glycol or a derivative thereof and segment B formed of polyamino acid, a derivative thereof or a salt of the foregoing, the segment B containing bulky amines of pKa value not higher than 7.4 or containing both primary amine and secondary amine, tertiary amine or quaternary ammonium salt;
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Accused Products
Abstract
The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
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Citations
13 Claims
- 1. A polyethylene glycol/polycation block copolymer characterized by having segment A formed of polyethylene glycol or a derivative thereof and segment B formed of polyamino acid, a derivative thereof or a salt of the foregoing, the segment B containing bulky amines of pKa value not higher than 7.4 or containing both primary amine and secondary amine, tertiary amine or quaternary ammonium salt;
Specification