Tissue engineered construct for supplementing or replacing a damaged organ
First Claim
1. A tissue-engineered construct for supplementing or replacing a damaged organ, the construct having the following characteristics:
- (a) differentiated cells on a three-dimensional biocompatible scaffold, wherein the differentiated cells originated from transferred pluripotent cells; and
(b) at least one physiological function of the organ.
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Abstract
The present invention provides methods and compositions for supplementing or replacing a damaged organ. The damaged organ to be supplemented or replaced in accordance with the present invention include, for example, kidney, heart, liver, spleen, pancreas, bladder, ureter and urethra. In one embodiment, the tissue-engineered construct of the invention has has at least the following characteristics: (a) differentiated cells on a three-dimensional biocompatible scaffold, wherein the differentiated cells originated from transferred pluripotent cells; and (b) at least one physiological function of the organ.
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Citations
21 Claims
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1. A tissue-engineered construct for supplementing or replacing a damaged organ, the construct having the following characteristics:
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(a) differentiated cells on a three-dimensional biocompatible scaffold, wherein the differentiated cells originated from transferred pluripotent cells; and
(b) at least one physiological function of the organ. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of producing a tissue-engineered construct for supplementing or replacing a damaged organ comprising:
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(a) contacting pluripotent cells with a three-dimensional biocompatible scaffold such that the cells attach to the scaffold;
(b) placing the pluripotent cells under conditions to result in differentiation to a desired cell type; and
(c) culturing the cells attached to the scaffold to produce a tissue layer having at least one physiological function of the organ, thereby producing a tissue-engineered construct. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification