Methods of screening for immuno-adjuvants and vaccines comprising anti-microtubule immuno-adjuvants
First Claim
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1. A method of screening for agents that stimulate the innate immune system in a mammal, comprising:
- (a) bringing a candidate agent into contact with a cellular component of said innate immune system, (b) testing said cellular component for the level of one or more markers associated with stimulation of said innate immune system, and (c) correlating said level with a probability that said candidate agent stimulates said innate immune system.
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Abstract
A method of screening for agents that stimulate the innate immune system in mammals employs markers that respond to Toll-like receptor binding. Agents identified in the assay boost both innate and adaptive immune responses, when administered alone or in combination with vaccines.
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Citations
26 Claims
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1. A method of screening for agents that stimulate the innate immune system in a mammal, comprising:
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(a) bringing a candidate agent into contact with a cellular component of said innate immune system, (b) testing said cellular component for the level of one or more markers associated with stimulation of said innate immune system, and (c) correlating said level with a probability that said candidate agent stimulates said innate immune system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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- 14. A method of stimulating the innate immune system in a mammal, comprising administering a vaccine and a microtubule depolymerizing agent to said mammal.
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21. A method of stimulating the innate immune system in a mammal, comprising:
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(a) selecting a mammal in need of increased innate immunity that does not have a cell proliferative disorder, and (b) administering a microtubule depolymerizing agent to said mammal. - View Dependent Claims (22, 23, 24)
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25. A vaccine that comprises a microtubule depolymerizing agent.
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26. The vaccine of claim 28, wherein said microtubule depolymerizing agent is selected from the list consisting of colchicine, vinblastine, vincristine, and demecolcine.
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