Nanoparticulate ebastine formulations
First Claim
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1. A stable nanoparticulate ebastine, or a salt or derivative thereof, composition comprising:
- (a) particles of ebastine or a salt or derivative thereof having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer.
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Abstract
The invention is directed to compositions comprising at least one nanoparticulate H1-histamine receptor antagonist, such as ebastine or a salt or derivative thereof, having improved dissolution rate providing a faster onset of drug availability. The nanoparticulate H1-histamine receptor antagonist particles, such as ebastine, have an effective average particle size of less than about 2000 nm and are useful in the treatment of seasonal and perennial allergic rhinitis and related diseases.
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Citations
23 Claims
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1. A stable nanoparticulate ebastine, or a salt or derivative thereof, composition comprising:
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(a) particles of ebastine or a salt or derivative thereof having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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- 20. A method of making a nanoparticulate ebastine, or a salt or derivative thereof, composition comprising contacting particles of an ebastine with at least one surface stabilizer for a time and under conditions sufficient to provide a nanoparticulate ebastine composition having an effective average particle size of less than about 2000 nm.
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22. A method for the treatment of seasonal and perennial allergic rhinitis, idiopathic chronic urticaria, or a related disease comprising the administration of a composition comprising:
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(a) particles of ebastine, or a salt or derivative thereof, having an effective particle size of less than about 2000 nm; and
(b) at least one surface stabilizer. - View Dependent Claims (23)
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Specification