Method of Drug Formulation Based on Increasing the affinity of Crystalline Microparticle Surfaces for Active Agents
First Claim
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1. A method of coating a preformed crystalline microparticle in suspension with an active agent comprising;
- i) adjusting the energetic interaction between the active agent and the crystalline microparticle independent of solvent removal; and
ii) adsorbing the active agent onto the surface of the microparticle.
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Abstract
Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.
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Citations
22 Claims
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1. A method of coating a preformed crystalline microparticle in suspension with an active agent comprising;
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i) adjusting the energetic interaction between the active agent and the crystalline microparticle independent of solvent removal; and
ii) adsorbing the active agent onto the surface of the microparticle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of coating a pre-formed crystalline microparticle in suspension with insulin comprising:
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i) adjusting the energetic interaction between the active agent and the crystalline microparticle independent of solvent removal; and
ii) absorbing the insulin onto the surface of the microparticles.
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Specification