System for cell enrichment
First Claim
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1. A system comprising a separation module adapted for removal of more than 99.5% of enucleated cells from a blood sample and retention of more than 99% of nucleated cells from a blood sample.
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Abstract
The present invention provides systems useful for the enrichment of analytes, for example, cells of selected types, including but not limited to blood cells, stem cells, and pathogens, in samples. The invention also provides methods for analyzing the condition of a patient based on characteristics identified through analysis of the analytes in case and control samples.
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25 Claims
- 1. A system comprising a separation module adapted for removal of more than 99.5% of enucleated cells from a blood sample and retention of more than 99% of nucleated cells from a blood sample.
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3. A system comprising:
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one or more first enrichment regions, wherein said enrichment regions comprise a two dimensional plurality of obstacles defining a first fluid flow path for a first analyte and a second fluid flow path for a second analyte wherein said first analyte and said second analyte have different hydrodynamic diameters;
an analyzer fluidly coupled to said one or more enrichment regions for obtaining data on said first analyte or said second analyte; and
a database for storing said data. - View Dependent Claims (4, 5, 6, 7, 8, 9, 24, 25)
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10. A method for identifying a characteristic associated with a condition in a patient comprising:
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obtaining a plurality of control samples;
obtaining a plurality of case samples;
applying each of said samples to a device comprising a plurality of obstacles that deflect a first analyte from said sample in a direction away from a second analyte of said blood sample wherein said first analyte and said second analyte have a different hydrodynamic diameter;
analyzing said first analyte from said samples to determine a characteristic of said first analyte; and
performing an association study based on said characteristic. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification