Detection of target analytes using particles and electrodes
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Accused Products
Abstract
The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
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Citations
24 Claims
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1-6. -6. (canceled)
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7. A method of detecting cells using colloid particles, comprising:
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a) forming an assay complex on a surface, wherein said assay complex comprises 1) said cells;
2) at least one colloid particle comprising a binding ligand; and
3) at least one signaling moiety that is either directly or indirectly attached to said assay complex; and
b) detecting said cells by detecting said signaling moiety. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A composition comprising a colloid particle comprising:
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1) at least one signaling moiety; and
2) a mixed self-assembled monolayer (SAM), wherein said SAM comprises at least two species of molecules. - View Dependent Claims (18, 19, 20, 21)
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22. A composition comprising a colloid particle comprising:
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a) a self-assembled monolayer (SAM); and
b) a non-DNA binding ligand attached to said colloid particle. - View Dependent Claims (23, 24)
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Specification