PREPARATION OF VACCINES USING A PHOTOSENSITIZER AND LIGHT
First Claim
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1. A method of making a vaccine from one or more infectious particles comprising:
- inactivating the infectious particles by adding an effective amount of an endogengous isoalloxazine photosensitizer to the one or more infectious particles and exposing the particles to light of a sufficient wavelength to prevent replication of the infectious particles but not substantially destroy the antigenic determinants of the particles; and
suspending the inactivated particles in a suspension solution to create a vaccine.
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Abstract
Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.
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Citations
23 Claims
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1. A method of making a vaccine from one or more infectious particles comprising:
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inactivating the infectious particles by adding an effective amount of an endogengous isoalloxazine photosensitizer to the one or more infectious particles and exposing the particles to light of a sufficient wavelength to prevent replication of the infectious particles but not substantially destroy the antigenic determinants of the particles; and
suspending the inactivated particles in a suspension solution to create a vaccine. - View Dependent Claims (2, 5)
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3-4. -4. (canceled)
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6-11. -11. (canceled)
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12. A method of making a vaccine containing a live virus comprising the steps of:
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adding an effective amount of an endogenous isoalloxazine photosensitizer to the virus and exposing the virus to light of a sufficient wavelength to prevent replication of the live virus but not substantially destroy the antigenic determinants of the virus to create an inactivated live virus; and
suspending the inactivated live virus in a suspension solution to create a vaccine. - View Dependent Claims (13, 14, 15)
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16. A method for inactivating infectious particles without substantially degrading the antigenic characteristics of the particles, comprising the steps of:
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exposing the infectious particles to an inactivation fluid containing at least an endogenous isoalloxazine photosensitizer in an amount sufficient to render the particles substantially non-infectious; and
exposing the infectious particles and inactivation fluid to light of a sufficient wavelength and for a sufficient time to render the particles substantially non-infectious but less than that which would result in degradation of the antigenic characteristics of the infectious particles. - View Dependent Claims (17, 19, 22)
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18. (canceled)
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20-21. -21. (canceled)
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23-29. -29. (canceled)
Specification