2' and 3'-nucleoside prodrugs for treating Flaviviridae infections
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Accused Products
Abstract
2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
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Citations
67 Claims
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1. (canceled)
- 2. A method for the treatment of a host infected with a Flaviviridae virus, comprising administering an effective treatment amount of a compound of formula
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4-7. -7. (canceled)
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18. (canceled)
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48. A method for the treatment of a host infected with a Flaviviridae virus, comprising administering an effective treatment amount of a compound of formula:
Specification