Benzazepine derivatives as histamine h3 antagonists
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Abstract
The present invention relates to novel benzazepine derivatives of structure (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders. These compounds act as histamine H3 antagonists.
26 Citations
12 Claims
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1-8. -8. (canceled)
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9. A compound of formula (I) or a pharmaceutically acceptable salt thereof:
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wherein;
R1 represents —
C3-7 cycloalkyl optionally substituted by C1-3 alkyl;
R2 represents hydrogen, —
C1-6 alkyl, —
C3-8 cycloalkyl, —
C1-6 alkyl-C3-8 cycloalkyl, -aryl, -heterocyclyl, -heteroaryl, —
C3-8 cycloalkyl-Y—
C3-8 cycloalkyl, —
C3-8 cycloalkyl-Y-aryl, —
C3-8 cycloalkyl-Y-heteroaryl, —
C3-8 cycloalkyl-Y-heterocyclyl, -aryl-Y—
C3-8 cycloalkyl, -aryl-Y-aryl, -aryl-Y-heteroaryl, -aryl-Y-heterocyclyl, -heteroaryl-Y—
C3-8 cycloalkyl, -heteroaryl-Y-aryl, -heteroaryl-Y-heteroaryl, -heteroaryl-Y-heterocyclyl, -heterocyclyl-Y—
C3-8 cycloalkyl, -heterocyclyl-Y-aryl, -heterocyclyl-Y-heteroaryl, -heterocyclyl-Y-heterocyclyl;
X represents a bond, CO, SO2, CONR5, COO or COC2-6 alkenyl;
Y represents a bond, C1-6 alkyl, CO, CONH, NHCO, O, SO2, SO2NH or NHSO2;
R3 represents halogen, C1-6 alkyl, C1-6 alkoxy, cyano, amino or trifluoromethyl;
R4 and R5 independently represent hydrogen, —
C1-6 alkyl, —
C3-8 cycloalkyl, -aryl, -heterocyclyl or -heteroaryl;
n is 0, 1 or 2;
wherein said alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl groups of R2, R3 and R4 may be optionally substituted by one or more substituents (e.g. 1, 2 or
3) which may be the same or different, and which are selected from the group consisting of halogen, hydroxy, cyano, nitro, ═
O, haloC1-6 alkyl, haloC1-6 alkoxy, C1-6 alkyl, C1-6 alkoxy, arylC1-6 alkoxy, C1-6 alkylthio, C1-6 alkoxyC1-6 alkyl, C3-7 cycloalkylC1-6 alkoxy, C1-6 alkanoyl, C1-6 alkoxycarbonyl, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, C1-6 alkylsulfonyloxy, C1-6 alkylsulfonylC1-6 alkyl, sulfonyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6 alkyl, aryloxy, C1-6 alkylsulfonamido, C1-6 alkylamino, C1-6 alkylamido, —
R8, —
CO2R8, —
COR8, C1-6 alkylsulfonamidoC1-6 alkyl, C1-6 alkylamidoC1-6 alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamidoC1-6 alkyl, arylcarboxamidoC1-6 alkyl, aryl, aroyl, aroylC1-6 alkyl, arylC1-6 alkanoyl, or a group —
NR6R7, —
C1-6 alkyl-NR6R7, —
C3-8 cycloalkyl-NR6R7, —
CONR6R7, —
NR6COR7, —
NR6SO2R7, —
OCONR6R7, NR6CO2R7, —
NR8CONR6R7 or —
SO2NR6R7 (wherein R6, R7 and R3 independently represent hydrogen, C1-6 alkyl, —
C3-8 cycloalkyl, —
C1-6 alkyl-C3-8 cycloalkyl, aryl, heterocyclyl or heteroaryl or —
NR6R7 may represent a nitrogen containing heterocyclyl group, wherein said R5, R6 and R7 groups may be optionally substituted by one or more substituents which may be the same or different, and which are selected from the group consisting of halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, cyano, amino, ═
O or trifluoromethyl);
or solvates thereof;
wherein said compound is not 7-amino-3-cyclopropyl-2,3,4,5-tetrahydro-1H-3-benzazepine. - View Dependent Claims (10, 11, 12)
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10. A compound according to claim 9 which is:
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N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-morpholinecarboxamide;
4-Cyano-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)tetrahydro-2H-pyran-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)acetamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)cyclopropanecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)methanesulfonamide;
6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)amino]-N-methyl-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(2-pyridinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-hydroxy-2-pyrazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(1,3-oxazol-4-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-iodobenzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(3-pyridinyl)benzamide;
N-(3-Cyclohexyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(1,3-oxazol-5-yl) benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(3,5-dimethyl-4-isoxazolyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-imidazo[1,2-a]pyridin-2-ylbenzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,5-oxadiazole-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-isoxazolecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)cyclohexane carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-cyclopentyl acetamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-methylbenzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-fluorobenzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-methyl-2-thiophenecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methylbenzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-methylbenzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-ethylbutanamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-fluorobenzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(5-pyrimidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(methylsulfonyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-quinoxalinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-1,6-naphthyridine-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(1H-tetrazol-1-yl)benzamide;
4-(6-Cyano-3-pyridinyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-methylnicotinamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-methylnicotinamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)nicotinamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(trifluoromethyl)nicotinamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-(1H-pyrazol-1-yl)nicotinamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-(trifluoromethyl)nicotinamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(5-methyl-1H-tetrazol-1-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(3-pyridinyl)-1H-pyrazole-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-(4-morpholinyl)-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1H-1,2,3-benzotriazole-5-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(2-pyrazinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-1,8-naphthyridine-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-quinoxaline carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-pyrimidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-pyridazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(5-pyrimidinyl) benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(2-pyrazinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(4-pyrimidinyl) benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(4-pyrimidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-3-isoxazolecarboxamide;
6-Cyano-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(1H-imidazol-1-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-pyrazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-methyl-2-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-thiophenecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-furancarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-3-furancarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,5-dimethyl-3-furancarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-5-phenyl-3-furancarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,3-thiadiazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3-thiazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-methyl-1H-imidazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-methyl-1H-1,2,3-triazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-phenyl-1,3-oxazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-phenyl-2H-1,2,3-triazole-4-carboxamide;
2-(2,1,3-Benzoxadiazol-5-yl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3-thiazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,5-thiadiazole-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-(1H-1,2,4-triazol-1-yl)-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-phenyl-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3,3′
-bipyridine-5-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-methyl-5-isoxazolecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-2-pyrazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-oxo-1,6-dihydro-2-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,4-dimethyl-1,3-thiazole-5-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-phenyl-1,3-thiazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(1,1-dioxido-2-isothiazolidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(2-oxo-1-pyrrolidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(2-oxo-1-imidazolidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(1H-pyrazol-1-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(1H-1,2,4-triazol-1-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(2-oxo-1-pyrrolidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(1,1-dioxido-2-isothiazolidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(2-oxo-1-imidazolidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(1H-pyrazol-1-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(1H-1,2,4-triazol-1-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-methyl-2,5-pyrazinedicarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(4-pyridinyl)benzamide;
6-(4-Cyanophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3′
-bipyridine-5-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-(5-pyrimidinyl)-3-pyridinecarboxamide;
6-(3-Cyanophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(4-fluorophenyl)-2-pyridinecarboxamide;
5-(4-Cyanophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-pyridinecarboxamide;
6′
-Cyano-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3,3′
-bipyridine-6-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(5-pyrimidinyl)-2-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(2-pyrazinyl)-2-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3′
-bipyridine-6′
-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(1H-pyrazol-1-yl)-2-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(1H-imidazol-1-yl)-2-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(1H-1,2,4-triazol-1-yl)-2-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(4-morpholinyl)-2-pyrazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(1-pyrrolidinyl)-2-pyrazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(1-piperidinyl)-2-pyrazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-2-pyrazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(phenyloxy)-2-pyrazinecarboxamide;
5-(4-Cyanophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-pyrazinecarboxamide;
5-(3-Cyanophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-pyrazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-biphenylcarboxamide;
3-Cyano-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3,5-dimethyl-4-isoxazolecarboxamide;
5-Bromo-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(1H-imidazol-1-yl)-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N-methyl-4-(2-pyrazinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N-methyl-4-(2-pyridinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N-methyl-4-(5-pyrimidinyl)benzamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N, 6-dimethyl-3-pyridinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-phenylurea;
N-(4-Cyanophenyl)-N′
-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)urea;
N-1,3-Benzodioxol-5-yl-N′
-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)urea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-cyclohexylurea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-(1-methylethyl)urea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-[2-(methyloxy)phenyl]urea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-8-quinolinylurea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-(2,2-difluoro-1,3-benzodioxol-4-yl)urea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-3-pyridinylurea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-4-pyridinylurea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-[2-(ethyloxy) phenyl]urea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-{2-[(trifluoromethyl)oxy]phenyl}urea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N′
-[2-methyl-6-(methyloxy)phenyl]urea;
N-(3-Cyanophenyl)-N′
-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)urea;
N-[5-Chloro-2-(methyloxy)phenyl]-N′
-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)urea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-pyrazin-2-ylpiperazine-1-carboxamide;
4-(5-Cyanopyridin-2-yl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)piperazine-1-carboxamide;
5-Chloro-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)indoline-1-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-1H-indole-1-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3,4-dihydro-1(2H)-quinolinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3-dihydro-2H-isoindole-2-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3,4-dihydro-2(1H)-isoquinolinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-phenyl-1-piperidinecarboxamide;
4-[(4-Cyanophenyl)oxy]-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(2-pyridinyl)-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(4-pyridinyl)-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-phenyl-1-piperazinecarboxamide;
4-(4-Cyanophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-piperazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-pyrrolidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-fluoro-2,3-dihydro-1H-indole-1-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(4-fluorophenyl)-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-phenyl-1-pyrrolidinecarboxamide;
5-Cyano-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-1H-indole-1-carboxamide;
4-(4-Cyanophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide;
4-(3-Cyano-2-pyrazinyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-piperazinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-{[4-(methyloxy)phenyl]oxy}-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-[(4-fluorophenyl)oxy]-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(phenyloxy)-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(2-pyridinyloxy)-1-piperidinecarboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(3-pyridinyloxy)-1-piperidinecarboxamide;
7-Cyano-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide;
N-(4-Cyanophenyl)-N′
-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-N-methylurea;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxamide;
5-Cyano-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3-dihydro-2H-isoindole-2-carboxamide;
1-{6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)amino]-3-pyridinyl}-2-pyrrolidinone;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3-benzodioxole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-1H-benzimidazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-quinoxalinecarboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-(methyloxy)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)pyrazolo[1,5-a]pyridine-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-1-[4-(methyloxy)phenyl]-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(methyloxy)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-benzothiophene-2-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-naphthalenecarboxamide trifluoroacetate;
1-(4-Chlorophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-(1-methylethyl)-1H-1,2,3-benzotriazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-(1-methylethyl)-2-(trifluoromethyl)-1H-benzimidazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,1-benzisoxazole-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-methyl-3-propyl-1H-pyrazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-2H-1,2,3-triazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-benzothiophene-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-phenyl-1H-1,2,3-triazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-methyl-5-[4-(methyloxy)phenyl]-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-[3-(methyloxy)phenyl]-1-phenyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-2-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-methyl-1-phenyl-1H-pyrazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-methyl-1H-1,2,3-benzotriazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-1-[(4-methylphenyl)methyl]-1H-pyrazole-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-ethyl-3-(2-thienyl)-1H-pyrazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-ethyl-5-methyl-1H-pyrazole-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-[(4-fluorophenyl)oxy]-1H-1,2,3-triazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-ethyl-1-phenyl-1H-1,2,3-triazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-ethyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-5-phenyl-2H-1,2,3-triazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2H-chromene-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-methyl-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide trifluoroacetate;
4-[3,4-bis(Methyloxy)phenyl]-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1H-1,2,3-triazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-(2,2,2-trifluoroethyl)-1H-1,2,3-triazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-methyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide trifluoroacetate;
1-(2-Chlorophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-propyl-1H-pyrazole-4-carboxamide trifluoroacetate;
1-(4-Cyanophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide trifluoroacetate;
1-(4-Chlorophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-propyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3,4-dihydro-2H-chromene-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3,5-tri methyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-benzofuran-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1H-indole-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1H-indazole-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-1-benzofuran-2-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1H-indole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-1-benzofuran-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3-benzothiazole-6-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1H-indole-6-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,3-benzothiadiazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-naphthalenecarboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-quinolinecarboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(methyloxy)-2-quinolinecarboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,1,3-benzothiadiazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-1,4-benzodioxin-2-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-6-(methyloxy)-2-naphthalenecarboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-isoquinolinecarboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-methyl-1H-indole-2-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-benzofuran-2-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(methyloxy)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3-diphenyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-quinolinecarboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2,3-dihydro-1,4-benzodioxin-6-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(methylsulfonyl)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-(phenyloxy)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(phenyloxy)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(phenyloxy)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-(trifluoromethyl)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(trifluoromethyl)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-4-(trifluoromethyl)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-2-biphenylcarboxamide trifluoroacetate;
(2E)-N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-phenyl-2-propenamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1H-benzimidazole-2-carboxamide trifluoroacetate;
(2E)-N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-[2-(methyloxy)phenyl]-2-propenamide trifluoroacetate;
(2E)-N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-[3-(methyloxy)phenyl]-2-propenamide trifluoroacetate;
(2E)-N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-[4-(methyloxy)phenyl]-2-propenamide trifluoroacetate;
(2E)-N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(2-fluorophenyl)-2-propenamide trifluoroacetate;
(2E)-N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(3-fluorophenyl)-2-propenamide trifluoroacetate;
(2E)-N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(4-fluorophenyl)-2-propenamide trifluoroacetate;
3,5-Dichloro-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-ethyl-3-methyl-1H-pyrazole-5-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-(2-furanyl)-1H-pyrazole-3-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-(3,4-dichlorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-3-(methyloxy)-2-naphthalenecarboxamide trifluoroacetate;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-(4-fluorophenyl)-5-phenyl-1H-pyrazole-3-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,5-diphenyl-1H-pyrazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-2-(4-methylphenyl)-2H-1,2,3-triazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-1-(2-methylphenyl)-1H-pyrazole-4-carboxamide;
N-(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1-(methyloxy)-2-naphthalenecarboxamide;
1-(4-Chlorophenyl)-N-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-1H-pyrazole-4-carboxamide;
5-Methyl-N-[3-(3-methylcyclopentyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-2-phenyl-2H-1,2,3-triazole-4-carboxamide;
N-(3-Cyclohexyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide;
5-Methyl-N-[3-(2-methylcyclopentyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-2-phenyl-2H-1,2,3-triazole-4-carboxamide trifluoroacetate;
orN-(3-Cyclopentyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide trifluoroacetate;
or a pharmaceutically acceptable salt or solvate thereof.
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11. A pharmaceutical composition which comprises a compound as defined in claim 9 or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier or excipient.
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12. A method of treatment of neurological diseases which comprises administering to a host in need thereof an effective amount of a compound as defined in claim 9 or a pharmaceutically acceptable salt or solvate thereof.
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Specification
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Current AssigneeGlaxo Group Limited (Glaxosmithkline Holdings Ltd.)
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Original AssigneeGlaxo Group Limited (Glaxosmithkline Holdings Ltd.)
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InventorsWilson, David, Witherington, Jason, Bailey, Nicholas, Dean, David, Bamford, Mark, Pickering, Paula
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Application NumberUS10/596,503Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current514/217.10CPC Class CodesA61P 25/00 Drugs for disorders of the ...A61P 25/06 Antimigraine agentsA61P 25/08 Antiepileptics; Anticonvuls...A61P 25/14 for treating abnormal movem...A61P 25/20 Hypnotics; SedativesA61P 25/28 for treating neurodegenerat...C07D 223/16 Benzazepines; Hydrogenated ...C07D 401/04 directly linked by a ring-m...C07D 401/12 linked by a chain containin...C07D 401/14 containing three or more he...C07D 403/12 linked by a chain containin...C07D 403/14 containing three or more he...C07D 405/12 linked by a chain containin...C07D 405/14 containing three or more he...C07D 409/12 linked by a chain containin...C07D 413/12 linked by a chain containin...C07D 417/12 linked by a chain containin...C07D 471/04 Ortho-condensed systems