Local perfusion device

• US 20070060918A1
• Filed: 08/22/2005
• Published: 03/15/2007
• Est. Priority Date: 08/22/2005
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Weber, Jan, Eidenschink, Tracee, Holman, Thomas
• Granted Patent: US 7,963,940 B2
• Time in Patent Office: Days
• US Class Current: 606/21
• CPC Class Codes: A61F 2007/0063 for cooling
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities

Abstract

A device for providing a fluid to a target tissue region of a body vessel is described. The device includes an elongate member having a lumen to receive a fluid, and a structure deployable from a distal portion of the elongate member to channel blood flowing in the vessel. Also described are a method of, and a system for, providing a fluid to a target tissue region inside a body.

Claims

1. A device for providing a fluid to a target tissue region of a body vessel, the device comprising:

an elongate member having a lumen extending longitudinally therethrough from an entry port near a proximal end and to at least one exit port near a distal end of the elongate member, the member being adapted to receive a fluid into the entry port so that the fluid exits the at least one exit port and into a region of the vessel near a target tissue region; and

a structure deployable from a distal portion of the elongate member, the deployable structure being adapted, when deployed, to channel blood flowing in the vessel and substantially isolate the blood flowing through the vessel from the region within the vessel near the target tissue region.

2. The device of claim 1, wherein the distal end of the device is advancable through a body vessel to the target tissue region when the structure is in a non-deployed state.

3. The device of claim 2, wherein the distal end of the device cannot be advanced through the body when the structure is in a deployed state.

4. The device of claim 1, wherein the proximal end of the elongate body remains outside the body when the distal end of the elongate body is positioned near the target tissue region.

5. The device of claim 1, further comprising a wire running from near the proximal end of the elongate member to a point of attachment to the structure, and wherein the structure is deployed from a distal portion of the elongate member by advancing the wire in a distal direction.

6. The device of claim 1, wherein the structure comprises a wire loop and a blood channeler having a generally tubular shape.

7. The device of claim 6, wherein the wire loop comprises a shape memory material.

8. The device of claim 6, wherein the blood channeler is adhesively bonded or welded to the wire loop.

9. The device of claim 6, wherein the blood channeler is formed from nylon, PET, Pebax, POC, polyurethane, PTFE, or other biocompatible polymer.

10. The device of claim 9, wherein the blood channeler comprises a mono-layer polymer material.

11. The device of claim 6, wherein the blood channeler comprises a layer of nano-laminates.

12. The device of claim 6, wherein the fluid exits the lumen distally of the wire loop and outside the blood channeler.

13. The device of claim 6, wherein the lumen extends distally of the wire loop and wraps around the outside of the deployable structure.

14. The device of claim 6, further comprising:

filter material attached to the outside of the distal end of the blood channeler; and

lines attached to the filter material such that material collected by the filter material is retained by the filter material when the deployable structure is retracted.

15. A device for providing a fluid to a target tissue region of a body vessel, the device comprising:

a structure deployable from a distal portion of the elongate member, the deployable structure being adapted, when deployed, to channel blood flowing in the vessel such that substantially all of the blood flowing through the vessel flows through the deployable structure; and

an elongate member having a lumen extending longitudinally therethrough from an entry port near a proximal end and to at least one exit port near a distal end of the elongate member, the member being adapted to receive a fluid into the entry port so that the fluid exits the at least one exit port and into the interior of the deployable structure deployed in a vessel near a target tissue region.

16. The device of claim 15, wherein the deployable structure comprises an inflatable blood channeler.

17. The device of claim 16, wherein fluid from the lumen is able to pass into the inside of the inflatable blood channeler, and wherein fluid is able to pass from the inside of the inflatable blood channeler into the blood being channeled through the deployable structure.

18. The device of claim 16, wherein the inflatable blood channeler is made from nylon, PET, Pebax, POC, polyurethane, PTFE, or other biocompatible polymer.

19. The device of claim 15, wherein the deployable structure comprises an expandable, non-inflatable material.

20. The device of claim 19, wherein the expandable, non-inflatable material comprises a mono-layer polymer.

21. The device of claim 19, wherein the deployable structure further comprises circumferential rings comprising a shape memory material.

22. The device of claim 21, wherein the shape memory material is a polymer.

23. The device of claim 21, wherein the shape memory material is nitinol.

24. The device of claim 19, wherein the deployable structure is self expanding.

25. The device of claim 24, wherein the deployable structure expands upon application of fluid pressure from the lumen.

26. The device of claim 24, wherein the deployable structure expands upon application of cooled fluid from the lumen.

27. The device of claim 15, wherein the lumen has a perfusion section with multiple exit ports allowing fluid flow from the lumen into the blood channeled through the interior of the deployable structure.

28. A method of providing a fluid to a target tissue region inside a body, comprising:

introducing the distal end of an elongate member having a lumen extending longitudinally therethrough from an entry port near a proximal end and to at least one exit port near a distal end of the elongate member, the member being adapted to receive a fluid into the entry port so that the fluid exits the at least one exit port and into a region of the vessel near a target tissue region in a body vessel;

deploying a deployable structure from a distal portion of the elongate member; and

passing fluid through the lumen to at least one exit port located near the target tissue region.

29. The method of claim 28, wherein the deployable structure is adapted to channel blood flowing in a body vessel and substantially isolate the blood flowing through the vessel from the target tissue region, and wherein the fluid passes from the lumen such that the target tissue region substantially receives only the fluid provided through the lumen while blood continues to flow through the deployable structure and past the target tissue region.

30. The method of claim 29, wherein the fluid is a cooled fluid and the temperature at the target tissue region is maintained for an extended period within a target temperature range.

31. The method of claim 29, further comprising trapping material dislodged by the fluid such that the trapped material does not enter the body vessel blood flow.

32. The method of claim 28, wherein the deployable structure is adapted such that substantially all of the blood flowing through the vessel near the target tissue region flows through the deployable structure, and wherein the fluid passes from the lumen into the blood passing through the deployable structure near the target tissue region.

33. The method of claim 32, wherein the deployable structure comprises an inflatable balloon.

34. The method of claim 28, wherein the target tissue region is located in a coronary artery.

35. The method of claim 28, wherein the fluid is a cooled fluid.

36. The method of claim 28, wherein the fluid comprises a drug.

37. A system for delivering fluid to a target tissue region inside the body, comprising:

a device comprising an elongate member having a lumen extending longitudinally therethrough from an entry port near a proximal end and to at least one exit port near a distal end of the elongate member, the member being adapted to receive a fluid into the entry port so that the fluid exits the at least one exit port;

a structure deployable from a distal portion of the elongate member, the deployable structure being adapted, when deployed, to channel blood flowing in the vessel near a target tissue region; and

a control system that controls the amount of fluid provided to the lumen and out of the exit port near the target tissue region.

38. The system of claim 37, wherein the system delivers a fluid comprising a drug to the target tissue region.

39. The system of claim 37, wherein the system delivers cooled fluid to the target tissue region to maintain the target region at a temperature that is below normal internal human body temperature.

40. A process, comprising:

diverting substantially all of the blood flowing through a body vessel from a target region inside a body such that the diverted blood does not exit the body; and

infusing a fluid from outside a body to treat the target region.