Attachment of material to an implantable frame by cross-linking

• US 20070061002A1
• Filed: 09/01/2006
• Published: 03/15/2007
• Est. Priority Date: 09/01/2005
• Status: Abandoned Application

• Current Assignee: Cook Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Case, Brian, Paul, Ram, Hoffman, Grant
• Application Number:
  US11/514,443
• Publication Number:
  US 20070061002A1
• Time in Patent Office: Days
• US Class Current: 623/1.130
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61L 27/3629 Intestinal tissue, e.g. small intestinal submucosa
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a frame and a cross-linkable material having at least one cross-linked region and a non cross-linked region, where the cross-linked region maintains the cross-linkable material in connection to the frame. A method of making an implantable medical device includes providing a frame and covering the frame with a cross-linkable material. The method also includes cross-linking at least one region of the cross-linkable material by joining a first region of the cross-linkable material to a second region of the cross-linkable material to form a point of attachment. A method of treating a subject includes the step of implanting the medical device at a point of treatment.

Claims

1. A medical device for implantation in a body vessel, comprising:

a frame; and

a cross-linkable material having at least one cross-linked region and a non cross-linked region, where the cross-linked region maintains the cross-linkable material in connection to the frame.

2. The medical device of claim 1, wherein the cross-linked region comprises cross-link bonds between a first region and a second region of the cross-linkable material.

3. The medical device of claim 1, wherein the cross-linked region is cross-linked to a first surface of the frame.

4. The medical device of claim 1, wherein the cross-linkable material is moveable relative to the frame.

5. The medical device of claim 1, wherein the cross-linkable material comprises extra cellular matrix material.

6. The medical device of claim 5, wherein the extra cellular matrix material comprises small intestine submucosa.

7. The medical device of claim 1, wherein the cross-linkable material comprises a polymer.

8. The medical device of claim 1, wherein the cross-linkable material comprises a cross-linkable tissue.

9. The medical device of claim 1, wherein the frame comprises a material selected from the group consisting of nickel, titanium, cobalt-chromium and stainless steel.

10. The medical device of claim 1, wherein the cross-linkable material defines a lumen comprising a valve means for regulating fluid flow through the lumen.

11. The medical device of claim 1, wherein the cross-linked region comprises cross-link bonds between a sugar and a protein.

12. The medical device of claim 1, wherein the frame comprises a cross-linkable polymer.

13. The medical device of claim 1, wherein the frame comprises small intestine submucosa.

14. A method of making an implantable medical device comprising:

providing a frame;

covering the frame with a cross-linkable material; and

cross-linking at least one region of the cross-linkable material.

15. The method of claim 14, wherein the cross-linking comprises forming a cross-linked region joining a first region of the cross-linkable material with a second region of the cross-linkable material.

16. The method of claim 15, wherein the cross-linked region is cross-linked to a first surface of the frame.

17. The method of claim 14, further comprising trimming excess cross-linkable material from the implantable medical device.

18. The method of claim 14, wherein the cross-linkable material is cross-linked by immersing the cross-linkable material in a cross-linking agent.

19. The method of claim 14, wherein the cross-linkable material forms cross-links when treated with glutaraldehyde.

20. The method of claim 14, wherein the cross-linkable material forms cross-links when treated with epoxyamine.

21. The method of claim 14, wherein the cross-linkable material is cross-linked by spraying the cross-linking agent onto the cross-linkable material.

22. A method of treating a subject comprising:

implanting a medical device at a point of treatment, the medical device comprising a frame and a cross-linkable material having a cross-linked region where the cross-linked region maintains the cross-linkable material in connection to the frame.