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Methods of modifying eukaryotic cells

  • US 20070061900A1
  • Filed: 11/09/2006
  • Published: 03/15/2007
  • Est. Priority Date: 10/31/2000
  • Status: Active Grant
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1. A transgenic mouse having a genome comprising human heavy and light chain immunoglobulin variable region gene loci, wherein the human heavy and light chain variable region loci replace mouse endogenous heavy and light chain immunoglobulin variable region gene loci, and the human heavy and light chain variable region loci are linked to endogenous mouse heavy and light chain immunoglobulin constant region gene loci to form hybrid loci, whereby the hybrid loci rearrange during B-cell development such that the mouse produces a serum containing an antibody comprising human heavy and light chain immunoglobulin variable regions and mouse heavy and light chain immunoglobulin constant regions in response to antigenic stimulation.

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