Method for enhancing memory and cognition in aging adults

• US 20070065789A1
• Filed: 02/02/2006
• Published: 03/22/2007
• Est. Priority Date: 01/13/2004
• Status: Abandoned Application

• Current Assignee: Posit Science Corp.
• Original Assignee: Posit Science Corp.
• Inventors: Goldman, Daniel, Merzenich, Michael, Mahncke, Henry, Zimman, Jeffrey, Hardy, Joseph
• Application Number:
  US11/346,627
• Publication Number:
  US 20070065789A1
• Time in Patent Office: Days
• US Class Current: 434/236
• CPC Class Codes: G09B 7/08 characterised by modifying the teaching programme in response to a wrong answer, e.g. repeating the question, supplying further information

Abstract

A method on a computing device is provided for enhancing the memory and cognitive ability of an older adult by requiring the adult to listen to two or more aurally processed syllables, presented serially, view the syllables graphically, and then designate the order in which the syllables were aurally presented. A number of trials are presented to the adult. As the adult correctly determines the syllable order in trials, the difficulty of the trials is increased by increasing the number of syllables presented, and by reducing the amount of processing that is applied to the syllables.

Claims

1. A computer-implemented method for enhancing memory and cognition in adults with impaired memory and cognition relative to a young healthy state, utilizing a computing device to present stimuli and to record responses, the method comprising:

presenting a stimulus to a user, wherein the user is an adult with impaired memory and cognition relative to a young healthy state;

recording a response of the user to the stimulus;

repeating said presenting and said recording a first specified number of times;

increasing difficulty of the stimulus if the user achieves a specified level of success;

decreasing the difficulty of the stimulus if the user does not achieve the specified level of success;

repeating said presenting, said recording, said repeating, said increasing, and said decreasing, a second specified number times to improve the memory and cognition of the adult.

2. The method of claim 1,

wherein the stimulus comprises an auditory stimulus;

wherein said increasing the difficulty of the stimulus comprises decreasing a level of processing of the auditory stimulus;

wherein said decreasing the difficulty of the stimulus comprises increasing the level of processing of the auditory stimulus.

3. The method of claim 2, wherein the level of processing of the auditory stimulus is based on one or more of:

modifying a rate at which at least a portion of the auditory stimulus is played, wherein said modifying maintains characteristic pitch-pulse-phase synchronous temporal structure of voiced speech sounds; and

emphasizing portions of the auditory stimulus, wherein said emphasizing uses band-modulation deepening to selectively enhance relatively fast-changing events in the voiced speech sounds.

4. The method of claim 1,

wherein the stimulus comprises an auditory frequency modulated (FM) sweep, wherein the FM sweep comprises a base frequency, a duration, and a direction of up or down;

wherein the response comprises a button press indicating the user'"'"'s perception of the direction of the sweep;

wherein said increasing the difficulty of the stimulus comprises decreasing the duration of the FM sweep; and

wherein said decreasing the difficulty of the stimulus comprises increasing the duration of the FM sweep.

5. The method of claim 4,

wherein the stimulus comprises a sequence of auditory FM sweeps, and wherein the sequence comprises a specified inter-stimulus interval (ISI) between each FM sweep in the sequence;

wherein the response comprises a corresponding sequence of button presses indicating the user'"'"'s perception of the respective directions of each FM sweep in the sequence;

wherein said increasing the difficulty of the stimulus comprises decreasing the duration of the FM sweep and/or decreasing the ISI; and

wherein said decreasing the difficulty of the stimulus comprises increasing the duration of the FM sweep and/or increasing the ISI.

6. The method of claim 4, further comprising:

performing said repeating said presenting, said recording, said repeating, said increasing, and said decreasing, for each of a plurality of base frequencies for the FM sweeps.

7. The method of claim 1,

wherein the stimulus comprises an auditory phoneme;

wherein the response comprises a button press identifying the phoneme from a plurality of confusable phonemes;

wherein said increasing the difficulty of the stimulus comprises decreasing emphasis of at least a portion of the auditory phoneme; and

wherein said decreasing the difficulty of the stimulus comprises increasing the emphasis of at least a portion of the auditory phoneme.

8. The method of claim 1,

wherein the stimulus comprises an array of buttons comprising a plurality of pairs of buttons, wherein each pair of buttons is associated with a respective phoneme, and wherein each button is pressable to invoke auditory presentation of the respective phoneme;

wherein the response comprises a sequential press of two buttons asserting that the two buttons are one of the plurality of pairs of buttons associated with a respective phoneme;

wherein said increasing the difficulty of the stimulus comprises decreasing emphasis of at least a portion of the auditory phoneme; and

wherein said decreasing the difficulty of the stimulus comprises increasing the emphasis of at least a portion of the auditory phoneme;

the method further comprising;

if the two buttons are one of the plurality of pairs of buttons associated with a respective phoneme, removing the two buttons from the array of buttons.

9. The method of claim 8,

wherein each button is associated with a randomly selected respective phoneme when first pressed by the user, and wherein the randomly selected respective phoneme is precluded from matching the respective phoneme associated with an immediately previously pressed button.

10. The method of claim 1,

wherein the stimulus comprises an auditory syllable;

wherein the response comprises a button press identifying the syllable from a plurality of syllables textually displayed on respective buttons;

wherein said increasing the difficulty of the stimulus comprises decreasing the level of processing of the auditory syllable;

wherein said decreasing the difficulty of the stimulus comprises increasing the level of processing of the auditory syllable; and

wherein the level of processing corresponds to the degree to which the syllable has been processed to enhance clarity of the auditory syllable.

11. The method of claim 10,

wherein the stimulus comprises a sequence of auditory syllables, and wherein the sequence comprises a specified inter-stimulus interval (ISI) between each auditory syllable in the sequence;

wherein the response comprises a corresponding sequence of button presses identifying the syllables in the sequence;

wherein said increasing the difficulty of the stimulus further comprises increasing the length of the sequence and/or decreasing the ISI; and

wherein said decreasing the difficulty of the stimulus further comprises decreasing the length of the sequence and/or increasing the ISI.

12. The method of claim 1,

wherein the stimulus comprises an auditory instruction indicating an action to be performed, wherein the action comprises a manipulation of a graphical object;

wherein the response comprises manipulating the graphical object;

wherein said increasing the difficulty of the stimulus comprises decreasing the level of processing of the auditory instruction and/or increasing the complexity of the instruction;

wherein said decreasing the difficulty of the stimulus comprises increasing the level of processing of the auditory instruction and/or decreasing the complexity of the instruction; and

wherein the level of processing corresponds to the degree to which the auditory instruction has been processed to enhance clarity of the auditory instructions.

13. The method of claim 12,

wherein the stimulus comprises a sequence of auditory instructions indicating a corresponding sequence of actions to be performed by the person, wherein the actions comprise respective manipulations of graphical objects;

wherein the response comprises manipulating the graphical objects;

wherein said increasing the difficulty of the stimulus further comprises increasing the length of the sequence; and

wherein said decreasing the difficulty of the stimulus further comprises decreasing the length of the sequence.

14. The method of claim 13, wherein the auditory instructions comprise:

instructions of lower complexity directed to stimulus discrimination;

instructions of higher complexity directed to stimulus discrimination;

instructions of lower complexity directed to memory; and

instructions of higher complexity directed to memory.

15. The method of claim 14, wherein each of the instructions of lower complexity directed to stimulus discrimination comprises an instruction to:

select a respective graphical object with a pointing device.

16. The method of claim 14, wherein each of the instructions of higher complexity directed to stimulus discrimination comprises an instruction to:

select a respective graphical object with a pointing device, wherein the respective graphical object is qualified by one or more adjectives and/or one or more prepositional phrases.

17. The method of claim 14, wherein each of the instructions of lower complexity directed to memory comprises an instruction to:

move a respective first graphical object with respect to a respective second graphical object.

18. The method of claim 14, wherein each of the instructions of higher complexity directed to memory comprises an instruction to:

move a respective first graphical object with respect to a respective second graphical object, wherein one or both of the respective first graphical object and the respective second graphical object are qualified by one or more adjectives and/or one or more prepositional phrases.

19. The method of claim 1,

wherein the stimulus comprises an auditory story segment and one or more questions about the auditory story segment;

wherein the response comprises respective button presses indicating respective answers to the one or more questions;

wherein said increasing the difficulty of the stimulus comprises increasing the complexity and/or decreasing the level of processing of the auditory story;

wherein said decreasing the difficulty of the stimulus comprises decreasing the complexity and/or decreasing the level of processing of the auditory story; and

wherein the level of processing corresponds to the degree to which the auditory story segment has been processed to enhance clarity of the auditory story segment.

20. The method of claim 19,

wherein the stimulus comprises a sequence of auditory story segments and respective questions about the auditory story segments;

wherein the response comprises respective button presses indicating respective answers to the respective questions about the story segments;

wherein said increasing the difficulty of the stimulus further comprises increasing the length of the sequence; and

wherein said decreasing the difficulty of the stimulus further comprises decreasing the length of the sequence.

21. The method of claim 20, the sequence of auditory story segments compose one or more stories with respective complexities, and wherein the complexity of each story is based on one or more of:

length of sentences in each story;

number of key elements in each story;

complexity of key elements in each story;

narrative relevance of key elements in each story; and

grammatical complexity of each story.

22. The method of claim 21, wherein the complexity of key elements in each story is based on one or more of:

use of adjectives, adjective phrases, adverbs, and/or adverb phrases qualifying the key elements of the story; and

use of prepositional phrases qualifying the key elements of the story.

23. The method of claim 21, wherein the narrative relevance of key elements in each story is based on one or more of:

whether a key element is a main element of a plot of the story; and

whether the key element is a background item of the story.

24. The method of claim 21, wherein grammatical complexity of each story is based on one or more of:

simple noun verb sentence structure of sentences in the story;

number of clauses used in the sentences in the story; and

nested clauses used in the sentences in the story.

25. A computer accessible memory medium comprising program instructions for enhancing memory and cognition in adults with impaired memory and cognition relative to a young healthy state, utilizing a computing device to present stimuli and to record responses, wherein the program instructions are executable to implement:

presenting a stimulus to a user, wherein the user is an adult with impaired memory and cognition relative to a young healthy state;

recording a response of the user to the stimulus;

repeating said presenting and said recording a first specified number of times;

increasing difficulty of the stimulus if the user achieves a specified level of success;

decreasing the difficulty of the stimulus if the user does not achieve the specified level of success;

repeating said presenting, said recording, said repeating, said increasing, and said decreasing, a second specified number times to improve the memory and cognition of the adult.

26. The memory medium of claim 25,

wherein the stimulus comprises an auditory stimulus;

wherein said increasing the difficulty of the stimulus comprises decreasing a level of processing of the auditory stimulus;

wherein said decreasing the difficulty of the stimulus comprises increasing the level of processing of the auditory stimulus.

27. The memory medium of claim 26, wherein the level of processing of the auditory stimulus is based on one or more of:

modifying a rate at which at least a portion of the auditory stimulus is played, wherein said modifying maintains characteristic pitch-pulse-phase synchronous temporal structure of voiced speech sounds; and

emphasizing portions of the auditory stimulus, wherein said emphasizing uses band-modulation deepening to selectively enhance relatively fast-changing events in the voiced speech sounds.

28. The memory medium of claim 25,

wherein the stimulus comprises an auditory frequency modulated (FM) sweep, wherein the FM sweep comprises a base frequency, a duration, and a direction of up or down;

wherein the response comprises a button press indicating the user'"'"'s perception of the direction of the sweep;

wherein said increasing the difficulty of the stimulus comprises decreasing the duration of the FM sweep; and

wherein said decreasing the difficulty of the stimulus comprises increasing the duration of the FM sweep.

29. The memory medium of claim 28,

wherein the stimulus comprises a sequence of auditory FM sweeps, and wherein the sequence comprises a specified inter-stimulus interval (ISI) between each FM sweep in the sequence;

wherein the response comprises a corresponding sequence of button presses indicating the user'"'"'s perception of the respective directions of each FM sweep in the sequence;

wherein said increasing the difficulty of the stimulus comprises decreasing the duration of the FM sweep and/or decreasing the ISI; and

wherein said decreasing the difficulty of the stimulus comprises increasing the duration of the FM sweep and/or increasing the ISI.

30. The memory medium of claim 28, wherein the program instructions are further executable to perform

performing said repeating said presenting, said recording, said repeating, said increasing, and said decreasing, for each of a plurality of base frequencies for the FM sweeps.

31. The memory medium of claim 25,

wherein the stimulus comprises an auditory phoneme;

wherein the response comprises a button press identifying the phoneme from a plurality of confusable phonemes;

wherein said increasing the difficulty of the stimulus comprises decreasing emphasis of at least a portion of the auditory phoneme; and

wherein said decreasing the difficulty of the stimulus comprises increasing the emphasis of at least a portion of the auditory phoneme.

32. The memory medium of claim 25,

wherein the stimulus comprises an array of buttons comprising a plurality of pairs of buttons, wherein each pair of buttons is associated with a respective phoneme, and wherein each button is pressable to invoke auditory presentation of the respective phoneme;

wherein the response comprises a sequential press of two buttons asserting that the two buttons are one of the plurality of pairs of buttons associated with a respective phoneme;

wherein said increasing the difficulty of the stimulus comprises decreasing emphasis of at least a portion of the auditory phoneme;

wherein said decreasing the difficulty of the stimulus comprises increasing the emphasis of at least a portion of the auditory phoneme; and

wherein the program instructions are further executable to perform

if the two buttons are one of the plurality of pairs of buttons associated with a respective phoneme, removing the two buttons from the array of buttons.

33. The memory medium of claim 32,

wherein each button is associated with a randomly selected respective phoneme when first pressed by the user, and wherein the randomly selected respective phoneme is precluded from matching the respective phoneme associated with an immediately previously pressed button.

34. The memory medium of claim 25,

wherein the stimulus comprises an auditory syllable;

wherein the response comprises a button press identifying the syllable from a plurality of syllables textually displayed on respective buttons;

wherein said increasing the difficulty of the stimulus comprises decreasing the level of processing of the auditory syllable;

wherein said decreasing the difficulty of the stimulus comprises increasing the level of processing of the auditory syllable; and

wherein the level of processing corresponds to the degree to which the syllable has been processed to enhance clarity of the auditory syllable.

35. The memory medium of claim 34,

wherein the stimulus comprises a sequence of auditory syllables, and wherein the sequence comprises a specified inter-stimulus interval (ISI) between each auditory syllable in the sequence;

wherein the response comprises a corresponding sequence of button presses identifying the syllables in the sequence;

wherein said increasing the difficulty of the stimulus further comprises increasing the length of the sequence and/or decreasing the ISI; and

wherein said decreasing the difficulty of the stimulus further comprises decreasing the length of the sequence and/or increasing the ISI.

36. The memory medium of claim 25,

wherein the stimulus comprises an auditory instruction indicating an action to be performed, wherein the action comprises a manipulation of a graphical object;

wherein the response comprises manipulating the graphical object;

wherein said increasing the difficulty of the stimulus comprises decreasing the level of processing of the auditory instruction and/or increasing the complexity of the instruction;

wherein said decreasing the difficulty of the stimulus comprises increasing the level of processing of the auditory instruction and/or decreasing the complexity of the instruction; and

wherein the level of processing corresponds to the degree to which the auditory instruction has been processed to enhance clarity of the auditory instructions.

37. The memory medium of claim 36,

wherein the stimulus comprises a sequence of auditory instructions indicating a corresponding sequence of actions to be performed by the person, wherein the actions comprise respective manipulations of graphical objects;

wherein the response comprises manipulating the graphical objects;

wherein said increasing the difficulty of the stimulus further comprises increasing the length of the sequence; and

wherein said decreasing the difficulty of the stimulus further comprises decreasing the length of the sequence.

38. The memory medium of claim 37, wherein the auditory instructions comprise:

instructions of lower complexity directed to stimulus discrimination;

instructions of higher complexity directed to stimulus discrimination;

instructions of lower complexity directed to memory; and

instructions of higher complexity directed to memory.

39. The memory medium of claim 38, wherein each of the instructions of lower complexity directed to stimulus discrimination comprises an instruction to:

select a respective graphical object with a pointing device.

40. The memory medium of claim 38, wherein each of the instructions of higher complexity directed to stimulus discrimination comprises an instruction to:

select a respective graphical object with a pointing device, wherein the respective graphical object is qualified by one or more adjectives and/or one or more prepositional phrases.

41. The memory medium of claim 38, wherein each of the instructions of lower complexity directed to memory comprises an instruction to:

move a respective first graphical object with respect to a respective second graphical object.

42. The memory medium of claim 38, wherein each of the instructions of higher complexity directed to memory comprises an instruction to:

move a respective first graphical object with respect to a respective second graphical object, wherein one or both of the respective first graphical object and the respective second graphical object are qualified by one or more adjectives and/or one or more prepositional phrases.

43. The memory medium of claim 25,

wherein the stimulus comprises an auditory story segment and one or more questions about the auditory story segment;

wherein the response comprises respective button presses indicating respective answers to the one or more questions;

wherein said increasing the difficulty of the stimulus comprises increasing the complexity and/or decreasing the level of processing of the auditory story;

wherein said decreasing the difficulty of the stimulus comprises decreasing the complexity and/or decreasing the level of processing of the auditory story; and

wherein the level of processing corresponds to the degree to which the auditory story segment has been processed to enhance clarity of the auditory story segment.

44. The memory medium of claim 43,

wherein the stimulus comprises a sequence of auditory story segments and respective questions about the auditory story segments;

wherein the response comprises respective button presses indicating respective answers to the respective questions about the story segments;

wherein said increasing the difficulty of the stimulus further comprises increasing the length of the sequence; and

wherein said decreasing the difficulty of the stimulus further comprises decreasing the length of the sequence.

45. The memory medium of claim 44, the sequence of auditory story segments compose one or more stories with respective complexities, and wherein the complexity of each story is based on one or more of:

length of sentences in each story;

number of key elements in each story;

complexity of key elements in each story;

narrative relevance of key elements in each story; and

grammatical complexity of each story.

46. The memory medium of claim 45, wherein the complexity of key elements in each story is based on one or more of:

use of adjectives, adjective phrases, adverbs, and/or adverb phrases qualifying the key elements of the story; and

use of prepositional phrases qualifying the key elements of the story.

47. The memory medium of claim 45, wherein the narrative relevance of key elements in each story is based on one or more of:

whether a key element is a main element of a plot of the story; and

whether the key element is a background item of the story.

48. The memory medium of claim 45, wherein grammatical complexity of each story is based on one or more of:

simple noun verb sentence structure of sentences in the story;

number of clauses used in the sentences in the story; and

nested clauses used in the sentences in the story.