Diffusion Delivery Systems and Methods of Fabrication

• US 20070066138A1
• Filed: 04/05/2006
• Published: 03/22/2007
• Est. Priority Date: 04/05/2005
• Status: Abandoned Application

• Current Assignee: Ohio State University
• Original Assignee: The Ohio State University Research Foundation
• Inventors: Ferrari, Mauro, Liu, Xuewu, Smith, Bryan, Sharma, Sadhana, Sinha, Piyush
• Application Number:
  US11/278,812
• Publication Number:
  US 20070066138A1
• Time in Patent Office: Days
• US Class Current: 439/607.10
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

The invention generally relates to diffusion delivery systems and more particularly to high precision nanoengineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.

Claims

1. A device, comprising:

a first substrate having a first face and a second substrate having a first face, wherein said first face of said first substrate is proximate to said first face of said second substrate, said first substrate comprising;

a first flow path having a plurality of first protrusions on said first face of said first substrate;

a second flow path having a plurality of second protrusions on said first face of said first substrate;

a plurality of diffusion areas;

wherein;

at least one of said plurality of first protrusions is disposed between a corresponding pair of second protrusions;

a diffusion area is disposed between said at least one of said plurality of first protrusions and each of said corresponding pair of second protrusions;

each of said plurality of first protrusions have an aspect ratio that allows each of said plurality of first protrusions to fill with a fluid.

2. The device according to claim 1, wherein each of said plurality of second protrusions have an aspect ratio that allows each of said plurality of second protrusions to fill with a fluid.

3. The device according to claim 1, wherein said second substrate further comprises at least one electrode.

4. The device according to claim 1, wherein said second substrate further comprises at least two electrodes.

5. The device according to claim 1, wherein one electrode is disposed in communication with said first flow path and one electrode is disposed in communication with said second flow path.

6. A device, comprising:

a first substrate having a first face and a second substrate having a first face, wherein said first face of said first substrate is proximate to said first face of said second substrate, said first substrate comprising;

a first flow path having a plurality of first protrusions on said first face of said first substrate, wherein each of said plurality of first protrusions has a depth and a width;

a second flow path having a plurality of second protrusions on said first face of said first substrate, wherein each of said plurality of second protrusions has a depth and a width;

a plurality of diffusion areas each of said plurality of diffusion areas having a length and a depth;

wherein;

at least one of said plurality of first protrusions is disposed between a corresponding pair of second protrusions;

a diffusion area is disposed between said at least one of said plurality of first protrusions and each of said corresponding pair of second protrusions; and

said at least one of said plurality of first protrusions has a cross-sectional area defined by the depth and the width of the first protrusion that is greater than the sum of the cross-sectional areas of the diffusion areas disposed between the at least one of said plurality of first protrusions and each of said corresponding pair of said second protrusions, said diffusion cross-sectional area being defined by the width and the height of the diffusion area.

7. The device according to claim 6, further comprising an entry port disposed in communication with the first flow path.

8. The device according to claim 6, further comprising an exit port disposed in communication with the second flow path.

9. The device according to claim 6, wherein each of said protrusions have a width of at least

10. The device according to claim 6, wherein each of said plurality of first protrusions have an aspect ratio that allows each of said plurality of first protrusions to completely fill with a fluid.

11. The device according to claim 6, wherein each of said plurality of second protrusions have an aspect ratio that allows each of said plurality of second protrusions to completely fill with a fluid.

12. The device according to claim 6, wherein said second substrate is glass and said first substrate is silicon.

13. The device according to claim 6, further comprising a plurality of first protrusions disposed between a corresponding pair of second protrusions.

14. The device according to claim 13, further comprising a diffusion area disposed between each of said plurality of first protrusions and each of said corresponding pair of second protrusions.

15. The device according to claim 6, wherein said second substrate further comprises at least one electrode.

16. The device according to claim 6, wherein said second substrate further comprises at least two electrodes.

17. The device according to claim 6, wherein one electrode is disposed in communication with said first flow path and one electrode is disposed in communication with said second flow path.

18. A device comprising:

a first substrate having a first and second face and having a plurality of first diffusion areas in said first substrate;

a second substrate having a first and second face and having a plurality of second

a third substrate having a first and second face;

a first flow path; and

a second flow path, wherein;

said second face of said first substrate is proximate to said second face of said second substrate;

said first face of said second substrate is proximate to said first face of said third substrate;

said first flow path is proximate to at least one of said plurality of first diffusion areas and at least one of said plurality of second diffusion areas; and

said second flow path is proximate to at least one of said plurality of first diffusion areas and at least one of said plurality of second diffusion areas.

19. The device according to claim 18, wherein one electrode is disposed in communication with said first flow path and one electrode is disposed in communication with said second flow path.

20. A device, comprising:

a first substrate having a first face and a second substrate having a first face, wherein said first face of said first substrate is proximate to said second face of said second substrate;

said first substrate having a first protrusion on said first face of said first substrate, wherein said first protrusion has first side, a second side, a depth, and a width;

a first diffusion area having a width and a height disposed proximate to said first side of said first protrusion; and

a second diffusion area having a width and a height, disposed proximate to said second side of said first protrusion, wherein said first protrusion has a cross-sectional area defined by said depth and said width of said first protrusion that is greater than the sum of a cross-sectional area of said first diffusion area defined by said width and said height of said first diffusion area and a cross-sectional area of said second diffusion area defined by said width and said height of said second diffusion area.