Compounds and methods for development of RET modulators
First Claim
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1. A method of inhibiting FRS2 interaction with and/or phosphorylation by FGFR in a cell, comprising contacting the cell with an agent that blocks FRS2 interaction with and/or phosphorylation by FGFR, under conditions under which the agent enters the cell.
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Abstract
Compounds active on Ret and/or FGFR are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
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8 Claims
- 1. A method of inhibiting FRS2 interaction with and/or phosphorylation by FGFR in a cell, comprising contacting the cell with an agent that blocks FRS2 interaction with and/or phosphorylation by FGFR, under conditions under which the agent enters the cell.
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