Iontophoresis device and method of producing the same

• US 20070066930A1
• Filed: 06/20/2006
• Published: 03/22/2007
• Est. Priority Date: 06/20/2005
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: Transcutaneous Technologies, Inc.
• Inventors: Tanioka, Akihiko, Nakayama, Mizuo, Matsumura, Akihiko, Matsumura, Takehiko, Akiyama, Hidero
• Application Number:
  US11/471,973
• Publication Number:
  US 20070066930A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.

Claims

1. An iontophoresis device for administering drug ions of a first polarity, generated by dissociation of a drug, to a living body, comprising an active electrode structure comprising:

a first conductive layer formed on a surface of a first substrate;

a drug layer comprising a drug coating containing the drug, the drug layer being deposited on the first conductive layer; and

a first ion exchange layer comprising of an ion exchange coating containing an ion exchange resin containing an exchange group having a counter ion to the first polarity ions, the first ion exchange layer being deposited on the drug layer.

2. An iontophoresis device according to claim 1, wherein the active electrode structure further comprises:

a first electrolyte layer comprising an electrolyte coating containing an electrolyte, the first electrolyte layer being deposited on the first conductive layer; and

a second ion exchange layer comprising an ion exchange coating containing an ion exchange resin containing an exchange group having a counter ion to a second polarity ion, the second ion exchange layer being deposited on the first electrolyte layer,

wherein the drug layer is deposited on the second ion exchange layer.

3. An iontophoresis device according to claim 1, further comprising a counter electrode structure comprising:

a second conductive layer formed on a surface of a second substrate;

a second electrolyte layer comprising an electrolyte coating containing an electrolyte, the second electrolyte layer being deposited on the second conductive layer;

a third ion exchange layer comprising an ion exchange coating containing an ion exchange resin containing an exchange group having a counter ion to the first polarity ions, the third ion exchange layer being deposited on the second electrolyte layer;

a third electrolyte layer comprising an electrolyte coating containing an electrolyte, the third electrolyte layer being deposited on the third ion exchange layer; and

a fourth ion exchange layer comprising an ion exchange coating containing an ion exchange resin containing an exchange group having a counter ion to the second polarity ions, the fourth ion exchange layer being deposited on the third electrolyte layer.

4. An iontophoresis device according to claim 1, wherein at least one of the drug coating and the electrolyte coating further contains a water-soluble polymer.

5. An iontophoresis device according to claim 1, wherein at least one of the first ion exchange layer, the second ion exchange layer, the third ion exchange layer, and the fourth ion exchange layer comprises a non-water-soluble coating film.

6. An iontophoresis device according to claim 5, wherein the ion exchange coating further contains one of a low molecular-weight polyethylene, ultra-high molecular weight PVA, chitosan, and a mixture thereof.

7. An iontophoresis device according to claim 1, wherein the drug layer is covered in its entirety by the first ion exchange layer.

8. An iontophoresis device according to claim 2, wherein the first electrolyte layer is covered in its entirety by the second ion exchange layer.

9. An iontophoresis device according to claim 3, wherein the second electrolyte layer is covered in its entirety by the third ion exchange layer.

10. An iontophoresis device according to claim 3, wherein the third electrolyte layer is covered in its entirety by the fourth ion exchange layer.

11. An iontophoresis device according to claim 3, wherein at least one of the first conductive layer and the second conductive layer comprises a coating film of a conductive coating.

12. An iontophoresis device according to claim 11, wherein the conductive coating contains a non-metallic conductive filler.

13. An iontophoresis device according to claim 3, wherein a single substrate has the first substrate as portion thereof and the second substrate as another portion thereof.

14. An iontophoresis device according to claim 3, wherein:

a first terminal conductor is formed on a reverse surface of the first substrate, and

the first conductor layer and the first terminal conductor are electrically connected to each other via a through-hole that passes through the first substrate.

15. An iontophoresis device according to claim 3, wherein:

a second terminal conductor is formed on a reverse surface of the second substrate, and

the second conductor layer and the second terminal conductor are electrically connected to each other via a through-hole that passes through the second substrate.

16. An iontophoresis device according to claim 3, wherein a thin battery is mounted on one of the surface and a reverse surface of at least one of the first substrate and the second substrate.

17. A method of producing an iontophoresis device for administering drug ions of a first polarity generated by dissociation of a drug to a living body, comprising:

forming a first conductive layer on a surface of a first substrate;

forming a drug layer by applying a drug coating containing the drug to the first conductive layer; and

forming a first ion exchange layer by applying an ion exchange coating containing an ion exchange resin containing an exchange group having a counter ion to the first polarity ions to the drug layer.

18. A method of producing an iontophoresis device according to claim 17, further comprising:

forming a first electrolyte layer by applying an electrolyte coating containing an electrolyte to the first conductive layer; and

forming a second ion exchange layer by applying an ion exchange coating containing an ion exchange resin containing an exchange group having a counter ion to second polarity ions to the first electrolyte layer,

wherein the drug layer is formed on the second ion exchange layer.

19. A method of producing an iontophoresis device according to claim 18, wherein at least one of the drug coating and the electrolyte coating further contains a water-soluble polymer.

20. A method of producing an iontophoresis device according to claim 18, further comprising setting at least one of the first ion exchange layer, the second ion exchange layer, the third ion exchange layer, and the fourth ion exchange layer to be non-water-soluble.

21. A method of producing an iontophoresis device according to claim 18, wherein the ion exchange coating further contains one of a low molecular-weight polyethylene, ultra-high molecular-weight PVA, chitosan, and a mixture thereof.

22. A method of producing an iontophoresis device according to claim 18, wherein the drug layer is covered in its entirety by the first ion exchange layer.

23. A method of producing an iontophoresis device according to claim 17, comprising:

forming a second conductive layer to a surface of a second substrate;

forming a second electrolyte layer by applying an electrolyte coating containing an electrolyte to the second conductive layer;

forming a third ion exchange layer by applying an ion exchange coating containing an ion exchange resin containing an exchange group having a counter ion to the first polarity ions to the second electrolyte layer;

forming a third electrolyte layer by applying an electrolyte coating containing an electrolyte to the third ion exchange layer; and

forming a fourth ion exchange layer by applying an ion exchange coating containing an ion exchange resin containing an exchange group having a counter ion to the second polarity ions to the third electrolyte layer.

24. A method of producing an iontophoresis device according to claim 23, wherein at least one of the drug coating and the electrolyte coating further contains a water-soluble polymer.

25. A method of producing an iontophoresis device according to claim 23, further comprising setting at least one of the first ion exchange layer, the second ion exchange layer, the third ion exchange layer, and the fourth ion exchange layer to be non-water-soluble.

26. A method of producing an iontophoresis device according to claim 25, wherein the ion exchange coating further contains one of a low molecular-weight polyethylene, ultra-high molecular-weight PVA, chitosan, and a mixture thereof.

27. A method of producing an iontophoresis device according to claim 23, wherein the drug layer is covered in its entirety by the first ion exchange layer.

28. A method of producing an iontophoresis device according to claim 23, wherein the first electrolyte layer is covered in its entirety by the second ion exchange layer.

29. A method of producing an iontophoresis device according to claim 23, wherein the second electrolyte layer is covered in its entirety by the third ion exchange layer.

30. A method of producing an iontophoresis device according to claim 23, wherein the third electrolyte layer is covered in its entirety by the fourth ion exchange layer.

31. A method of producing an iontophoresis device according to claim 23, wherein at least one of the first conductive layer and the second conductive layer is formed by application of a conductive coating.

32. A method of producing an iontophoresis device according to claim 31, wherein the conductive coating contains a non-metallic conductive filler.

33. A method of producing an iontophoresis device according to claim 23, wherein a single substrate has the first substrate as portion thereof and the second substrate as another portion thereof.

34. A method of producing an iontophoresis device according to claim 23, wherein:

a first terminal conductor is formed on a reverse surface of the first substrate, and

the first conductor layer and the first terminal conductor are electrically connected to each other via a through-hole that passes through the first substrate.

35. A method of producing an iontophoresis device according to claim 23, wherein:

a second terminal conductor is formed on a reverse surface of the second substrate, and

the second conductor layer and the second terminal conductor are electrically connected to each other via a through-hole that passes through the second substrate.

36. A method of producing an iontophoresis device according to claim 23, further comprising mounting a thin battery on one of the surface and a reverse surface of at least one of the first substrate and the second substrate.