Closed-loop micro-control system for predicting and preventing epilectic seizures
First Claim
1. A micro-control neuroprosthetic device for predicting and controlling epileptic neuronal activity, comprising:
- a detection system that detects and collects electrophysiological information comprising action potentials of single or ensembles of neurons in a neural structure;
an analysis system that evaluates the detected and collected electrophysiological information and performs a real-time extraction of neuron firing features and from the extracted features determines when electrical stimulus intervention is required;
a stimulation intervention system that provides electrical stimulus output signals having a desired stimulation frequency and stimulation intensity directly to the neural structure being monitored and in which abnormal neuronal activity is detected; and
wherein the analysis system further analyzes collected electrophysiological information following electrical stimulus intervention to assess the short-term effects of the stimulation intervention and to provide outputs to maintain or modify such stimulation intervention.
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Abstract
The invention provides a micro-control neuroprosthetic device and methods for predicting and controlling epileptic neuronal activity. The device includes a detection system that detects and collects electrophysiological information comprising action potentials from single neurons and ensembles of neurons in a neural structure such as an epileptogenic region of the brain in a subject. An analysis system included in the neuroprosthetic device evaluates the electrophysiological information and performs a real-time extraction of neuron firing features from which the system determines when stimulus intervention is required. The neuroprosthetic device further comprises a stimulation intervention system that provides stimulus output signals having a desired stimulation frequency and stimulation intensity directly to the neural structure in which abnormal neuronal activity is detected. The analysis system further analyzes collected electrophysiological information during or following stimulus intervention to assess the effects of the stimulation intervention and to provide outputs to maintain or modify the stimulation intervention.
174 Citations
10 Claims
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1. A micro-control neuroprosthetic device for predicting and controlling epileptic neuronal activity, comprising:
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a detection system that detects and collects electrophysiological information comprising action potentials of single or ensembles of neurons in a neural structure;
an analysis system that evaluates the detected and collected electrophysiological information and performs a real-time extraction of neuron firing features and from the extracted features determines when electrical stimulus intervention is required;
a stimulation intervention system that provides electrical stimulus output signals having a desired stimulation frequency and stimulation intensity directly to the neural structure being monitored and in which abnormal neuronal activity is detected; and
wherein the analysis system further analyzes collected electrophysiological information following electrical stimulus intervention to assess the short-term effects of the stimulation intervention and to provide outputs to maintain or modify such stimulation intervention. - View Dependent Claims (2, 3, 4)
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5. A method for controlling epileptic neuronal activity, comprising the steps of:
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monitoring a neural structure and detecting and collecting electrophysiological information comprising action potentials of single or ensembles of neurons in the neural structure being monitored;
analyzing the detected and collected electrophysiological information;
performing a real-time extraction of neuron firing features;
determining from the real-time extraction of neuron firing features the onset of an epileptic state and of abnormal neural firing; and
providing electrical stimulation output signals having a desired stimulation frequency and stimulation intensity to at least a portion of a neural structure being monitored responsive to said determining, to control the epileptic neuronal activity. - View Dependent Claims (6, 7, 8, 9, 10)
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Specification