Apparatus and method for computer modeling type 1 diabetes
First Claim
1. A method for developing a model of type 1 diabetes said method comprising:
- identifying one or more biological processes associated with a pancreatic lymph node;
identifying one or more biological processes associate with one or more pancreatic islets;
mathematically representing each biological process to generate one or more representations of a biological process associated with the pancreatic lymph node and one or more representations of a biological process associated with the one or more pancreatic islets; and
combining the representations of biological processes to form a model of type 1 diabetes.
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Abstract
The invention encompasses novel methods for developing a computer model of type 1 diabetes in a mammal. In particular, the models can include representations of biological processes associated with a pancreatic lymph node and one or more pancreatic islets. Alternatively, the models can include representations of biological processes associated with at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming, insulitis and hyperglycemia. The invention also provides methods for developing a computer model of a non-insulin replacement treatment of type 1 diabetes. The invention also encompasses computer models of type 1 diabetes, methods of simulating type 1 diabetes and computer systems for simulating type 1 diabetes and the uses thereof.
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Citations
59 Claims
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1. A method for developing a model of type 1 diabetes said method comprising:
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identifying one or more biological processes associated with a pancreatic lymph node;
identifying one or more biological processes associate with one or more pancreatic islets;
mathematically representing each biological process to generate one or more representations of a biological process associated with the pancreatic lymph node and one or more representations of a biological process associated with the one or more pancreatic islets; and
combining the representations of biological processes to form a model of type 1 diabetes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A computer-readable medium having computer-readable instructions stored thereon that, upon execution by a processor, cause the processor to simulate type 1 diabetes, and further wherein the instructions comprise:
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a) mathematically representing one or more biological processes associated with a pancreatic lymph node;
b) mathematically representing one or more biological processes associated with one or more pancreatic islets;
c) defining a set of mathematical relationships between the representations of biological processes to form a model of type 1 diabetes. - View Dependent Claims (15, 16, 17, 18, 19, 49, 53, 54)
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20. A system, comprising:
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a) a processor including computer-readable instructions stored thereon that, upon execution by a processor, cause the processor to simulate type 1 diabetes in a mammal, the computer readable instructions comprising;
i) mathematically representing one or more biological processes associated with a pancreatic lymph node;
ii) mathematically representing one or more biological processes associated with one or more pancreatic islets;
iii) defining a set of mathematical relationships between the representations of biological processes associated with the pancreatic lymph node and representations of biological processes associated with the one or more pancreatic islets;
iv) applying a virtual protocol to the set of mathematical relationships to generate a set of outputs;
b) a first user terminal, the first user terminal operable to receive a user input specifying one or more parameters associated with one or more mathematical representations defined by the computer readable instructions; and
c) a second user terminal, the second user terminal operable to provide the set of outputs to a second user.
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21. A method for developing a model of progression of type 1 diabetes said method comprising:
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identifying one or more biological processes associated with development of each of at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming;
insulitis and hyperglycemia;
mathematically representing each biological process to generate one or more representations of a biological process associated with each of the at least two conditions; and
combining the representations of biological processes to form a model of progression of type 1 diabetes. - View Dependent Claims (22, 23, 24)
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25. A computer-readable medium having computer-readable instructions stored thereon that, upon execution by a processor, cause the processor to simulate progression of type 1 diabetes, and further wherein the instructions comprise:
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a) mathematically representing one or more biological processes associated with development of each of at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming;
insulitis and hyperglycemia;
b) defining a set of mathematical relationships between the representations of biological processes to form a model of progression of type 1 diabetes. - View Dependent Claims (26, 27, 28, 29)
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30. A system, comprising:
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a) a processor including computer-readable instructions stored thereon that, upon execution by a processor, cause the processor to simulate progression of type 1 diabetes in a mammal, the computer readable instructions comprising;
i) mathematically representing one or more biological processes associated with development of each of at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming;
insulitis and hyperglycemia;
ii) defining a set of mathematical relationships between the representations of biological processes associated with the at least two conditions;
iii) applying a virtual protocol to the set of mathematical relationships to generate a set of outputs;
b) a first user terminal, the first user terminal operable to receive a user input specifying one or more parameters associated with one or more mathematical representations defined by the computer readable instructions; and
c) a second user terminal, the second user terminal operable to provide the set of outputs to a second user.
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31. A method for developing a model of a non-insulin replacement treatment of type 1 diabetes said method comprising:
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identifying one or more biological processes associated with a β
cell population in at least one of one or more pancreatic islets;
identifying one or more biological processes associated with an effect of the non-insulin replacement treatment of type 1 diabetes;
mathematically representing each biological process to generate one or more representations of a biological process associated with the β
cell population and one or more representations of a biological process associated with an effect of the non-insulin replacement treatment of type 1 diabetes; and
combining the representations of biological processes to form a model of a non-insulin replacement treatment of type 1 diabetes. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A computer-readable medium having computer-readable instructions stored thereon that, upon execution by a processor, cause the processor to a non-insulin replacement treatment of type 1 diabetes and further wherein the instructions comprise:
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a) mathematically representing one or more biological processes associated with a cell population in at least one of one or more pancreatic islets;
b) mathematically representing one or more biological processes associated with an effect of the non-insulin replacement treatment of type 1 diabetes;
c) defining a set of mathematical relationships between the representations of biological processes to form a model of the non-insulin replacement treatment of type 1 diabetes. - View Dependent Claims (42, 43, 44, 45, 46, 47, 50, 51, 52)
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48. A system, comprising:
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a) a processor including computer-readable instructions stored thereon that, upon execution by a processor, cause the processor to simulate progression of type 1 diabetes in a mammal, the computer readable instructions comprising;
i) mathematically representing one or more biological processes associated with one or more pancreatic islets;
ii) mathematically representing one or more biological processes associated with a β
cell population in at least one of the one or more pancreatic islets;
iii) mathematically representing one or more biological processes associated with an effect of a non-insulin replacement treatment of type 1 diabetes;
iv) defining a set of mathematical relationships between the representations of biological processes associated with the one or more pancreatic islets and the representations of biological processes associated with the β
cell population and the representations associated with an effect of the non-insulin replacement treatment of type 1 diabetes;
v) applying a virtual protocol to the set of mathematical relationships to generate a set of outputs;
b) a first user terminal, the first user terminal operable to receive a user input specifying one or more parameters associated with one or more mathematical representations defined by the computer readable instructions; and
c) a second user terminal, the second user terminal operable to provide the set of outputs to a second user.
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- 55. A computer-based mathematical model of a biological system comprising a representation of a tissue, wherein the tissue comprises a plurality of distinct distributed sites and the representation of the tissue comprises a plurality of representations, wherein each of the plurality of representations associated with one of the plurality of distinct distributed sites.
Specification