In VIVO formed matrices including natural biodegradale polysaccharides and ophthalmic uses thereof

• US 20070071792A1
• Filed: 09/21/2006
• Published: 03/29/2007
• Est. Priority Date: 09/21/2005
• Status: Abandoned Application

• Current Assignee: Surmodics Incorporated
• Original Assignee: Surmodics Incorporated
• Inventors: Varner, Signe, Chudzik, Stephen, Burkstrand, Michael, Beeley, Nathan
• Application Number:
  US11/524,925
• Publication Number:
  US 20070071792A1
• Time in Patent Office: Days
• US Class Current: 424/427
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/205 Polysaccharides, e.g. alginate, gums; Cyclodextrin
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 5/16 Cyclodextrin; Derivatives thereof

Abstract

In vivo formed matrices including natural biodegradable polysaccharides are described. The matrix is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The matrix can also include a bioactive agent that can be released to provide a therapeutic effect to a patient. The formed matrices are particularly useful for treatment of the eye.

Claims

1. A method for forming a biodegradable implant in situ, in an eye of a patient, the method comprising steps of:

(a) administering a composition to a patient, the composition comprising

(i) natural biodegradable polysaccharide comprising a coupling group,

(ii) an initiator, and

(iii) bioactive agent;

(b) activating the initiator to couple the natural biodegradable polysaccharides present in the composition, thereby forming a solid implant within the eye of the patient.

2. The method according claim 1 wherein the biodegradable polysaccharide is selected from the group consisting of amylose and maltodextrin.

3. The method according to claim 1 wherein the biodegradable polysaccharide comprises a non-reducing natural biodegradable polysaccharide.

4. The method according to claim 1 wherein the biodegradable polysaccharide comprises a pendent retinoic acid group.

5. The method according to claim 1 wherein the coupling group comprises a polymerizable group.

6. The method according to claim 5 wherein the polymerizable group is selected from vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups.

7. The method according to claim 1 wherein the initiator comprises a photoinitiator.

8. The method according to claim 1 wherein the step of administering comprises injecting the composition into a targeted site within the eye of the patient.

9. The method according to claim 8 wherein the targeted site is within the vitreous of the eye.

10. The method according to claim 8 wherein the targeted site is a subretinal area of the eye.

11. The method according to claim 1 wherein the step of activating the initiator comprises applying light having a wavelength in a visible or long wavelength ultraviolet range.

12. The method according to claim 11 wherein the step of activating comprises applying the light from a light source located within the interior of the eye.

13. The method according to claim 11 wherein the step of activating comprises applying the light from a light source located externally from the eye.

14. The method according to claim 1 wherein the step of activating the initiator is performed after the composition has been administered to the patient.

15. A method for forming a biodegradable implant in situ, in an eye of a patient, the method comprising steps of

(a) providing a first composition comprising

(i) natural biodegradable polysaccharide comprising a pendent polymerizable group, and

(ii) a first member of a redox pair;

(b) providing a second composition comprising

(i) natural biodegradable polysaccharide comprising a pendent polymerizable group, and

(ii) a second member of a redox pair;

(c) administering the first composition, the second composition, or a mixture of the first and second composition in liquid form into the eye of a patient; and

(d) contacting the first composition with the second composition where, in the step of contacting, the redox pair initiates polymerization of the natural biodegradable polysaccharides, thereby forming a solid implant within the eye.

16. The method according to claim 15 wherein the biodegradable polysaccharide is selected from the group consisting of amylose and maltodextrin.

17. The method according to claim 15 wherein the biodegradable polysaccharide comprises a non-reducing natural biodegradable polysaccharide.

18. The method according to claim 15 wherein the biodegradable polysaccharide of the first composition, the second composition, or both the first composition and second composition comprises a pendent retinoic acid group.

19. The method according to claim 15 comprising the sequential steps of:

(e) contacting the first composition with the second composition; and

(f) then administering the mixture of the first and second composition into the eye.

20. The method according to claim 15 wherein the step of administering comprises injecting the first composition, the second composition, or a mixture of the first and second composition in liquid form into the eye of a patient.

21. The method according to claim 15 wherein the natural biodegradable polysaccharide of the first composition is the same as the natural biodegradable polysaccharide of the second composition.

22. The method according to claim 15 wherein the redox pair comprises an oxidizing member selected from peroxides, metal oxides, and oxidases, and a reducing member selected from salts and derivatives of electropositive elemental metals and reductases.

23. The method according to claim 15 wherein the polymerizable group is selected from vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups.

24. The method according to claim 15 further comprising providing a bioactive agent to the first composition, the second composition, or both the first composition and the second composition.